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COVID-19 patients i...
COVID-19 patients in intensive care develop predominantly oliguric acute kidney injury
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- Luther, Tomas (författare)
- Uppsala universitet,Anestesiologi och intensivvård
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- Bûlow Anderberg, Sara (författare)
- Uppsala universitet,Anestesiologi och intensivvård
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- Larsson, Anders (författare)
- Uppsala universitet,Klinisk kemi
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- Rubertsson, Sten (författare)
- Uppsala universitet,Anestesiologi och intensivvård
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- Lipcsey, Miklós (författare)
- Uppsala universitet,Anestesiologi och intensivvård,Hedenstiernalaboratoriet
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- Frithiof, Robert (författare)
- Karolinska Institutet,Uppsala universitet,Anestesiologi och intensivvård
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- Hultström, Michael, 1978- (författare)
- Uppsala universitet,Anestesiologi och intensivvård,Integrativ Fysiologi
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(creator_code:org_t)
- 2020-11-28
- 2021
- Engelska.
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Ingår i: Acta Anaesthesiologica Scandinavica. - : John Wiley & Sons. - 0001-5172 .- 1399-6576. ; 65:3, s. 364-372
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://onlinelibrar...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- BACKGROUND: Acute kidney Injury (AKI) is a syndrome of reduced glomerular filtration rate and/or reduced urine flow associated with mortality in corona virus disease 2019 (COVID-19). AKI is often associated with renal tissue damage, which may lead to chronic kidney disease. Biomarkers of tissue damage may identify patients of particular risk.METHODS: In a prospective observational study of 57 patients admitted to intensive care, AKI incidence and characteristics was evaluated according to KDIGO criteria and related to days after admission. Urinary albumin, Neutrophil Gelatinase-Associated Lipocalin (NGAL), Kidney Injury Molecule 1 (KIM-1) and Plasma Tissue Inhibitor of MetalloProteinase 2 (TIMP-2) were analysed in 52 patients at admission.RESULTS: The majority (n=51, 89%) of patients developed AKI, and 27 (47%) patients had predominantly oliguric AKI where oliguria was more severe than plasma Creatinine increase. Severe oliguria within first 2 days after admission was common (n=37, 65%) while stage 2 and 3 AKI due to Creatinine occurred later than day 2 in 67% (12/18) of cases. Renal replacement therapy was started in 9 (16%) patients, and 30-day mortality was 28%. Urinary biomarkers were increased in a majority of patients, but did not robustly predict KDIGO stage. Most patients had microalbuminuria, and severe albuminuria (albumin Creatinine ratio > 30 mg/mmol) was found in n=9 (17%) patients.CONCLUSIONS: A majority of patients with COVID-19 admitted to the ICU develop AKI. The functional deficit is often low urinary volume, and initial levels of biomarkers are generally increased without clear relation to final AKI stage.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Anestesi och intensivvård (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Anesthesiology and Intensive Care (hsv//eng)
Nyckelord
- COVID-19
- acute kidney injury
- biomarkers
- intensive care
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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