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High incidence but ...
High incidence but low mortality of EBV-reactivation and PTLD after alloHCT using ATG and PTCy for GVHD prophylaxis
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Queralt Salas, Maria (författare)
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Prem, Shruti (författare)
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- Remberger, Mats (författare)
- Uppsala universitet,Hematologi
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Lam, Wilson (författare)
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Dong Hwan Kim, Dennis (författare)
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Michelis, Fotios Vasilios (författare)
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Al-Shaibani, Zeyad (författare)
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Gerbitz, Armin (författare)
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Lipton, Jeffrey Howard (författare)
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Viswabandya, Auro (författare)
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Kumar, Rajat (författare)
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Kumar, Deepali (författare)
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- Mattsson, Jonas (författare)
- Karolinska Institutet
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Datt Law, Arjun (författare)
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(creator_code:org_t)
- 2020-07-25
- 2020
- Engelska.
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Ingår i: Leukemia and Lymphoma. - : Informa UK Limited. - 1042-8194 .- 1029-2403. ; 61:13, s. 3198-3208
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- We explore risk factors and impacts of post-transplant EBV-Reactivation (EBV-R) and PTLD in 270 patients that underwent RIC alloHCT using ATG-PTCy and cyclosporine for GVHD prophylaxis. Twenty-five (12%) patients had probable (n = 7) or proven (n = 18) PTLD. Patients were managed with reduction of immunosuppression and 22 with weekly rituximab (375 mg/m2 IV). ORR was 84%; 8 (32%) recipients died, and one-year OS and NRM of patients with PTLD was 59.7% and 37%, respectively. One hundred seventy-two (63.7%) recipients had EBV-R. One-year OS and RFS of patients with EBV-R were 68.2% and 60.6%, and of EBV-Negative patients were 62.1% and 50.1%, respectively. High incidence but low mortality of EBV-R and PTLD was documented. EBV-R induced a protective effect on RFS in multivariable analysis (HR 0.91, p = .011). Therefore, EBV-R may have a protective effect on RFS in this setting. Further research is necessary to evaluate the interplay of EBV-R, immune reconstitution, and post-transplant outcomes.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Nyckelord
- Epstein-Barr Virus
- PTLD
- alloHCT
- reduced intensity conditioning
- ATG
- PTCy
- Klinisk immunologi
- Clinical Immunology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Queralt Salas, M ...
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Prem, Shruti
-
Remberger, Mats
-
Lam, Wilson
-
Dong Hwan Kim, D ...
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Michelis, Fotios ...
-
visa fler...
-
Al-Shaibani, Zey ...
-
Gerbitz, Armin
-
Lipton, Jeffrey ...
-
Viswabandya, Aur ...
-
Kumar, Rajat
-
Kumar, Deepali
-
Mattsson, Jonas
-
Datt Law, Arjun
-
visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Hematologi
- Artiklar i publikationen
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Leukemia and Lym ...
- Av lärosätet
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Uppsala universitet
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Karolinska Institutet