Permeability of the Endothelial Barrier: Identifying and Reconciling Controversies

Claesson-Welsh, LenaUppsala universitet,Science for Life Laboratory, SciLifeLab,Vaskulärbiologi,Claesson-Welsh (författare)

Permeability of the Endothelial Barrier : Identifying and Reconciling Controversies

Leakage from blood vessels into tissues is governed by mechanisms that control endothelial barrier function to maintain homeostasis. Dysregulated endothelial permeability contributes to many conditions and can influence disease morbidity and treatment. Diverse approaches used to study endothelial permeability have yielded a wealth of valuable insights. Yet, ongoing questions, technical challenges, and unresolved controversies relating to the mechanisms and relative contributions of barrier regulation, transendothelial sieving, and transport of fluid, solutes, and particulates complicate interpretations in the context of vascular physiology and pathophysiology. Here, we describe recent in vivo findings and other advances in understanding endothelial barrier function with the goal of identifying and reconciling controversies over cellular and molecular processes that regulate the vascular barrier in health and disease.

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Cell- och molekylärbiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Cell and Molecular Biology hsv//eng
G protein-coupled receptors
Rho GTPases
VEGF receptors
endothelial barrier function
endothelial cell junctions
gap formation
postcapillary venules

Dejana, ElisabettaUppsala universitet,Vaskulärbiologi,Science for Life Laboratory, SciLifeLab,IFOM-FIRC Institute of Molecular Oncology, Milan, Italy,Elisabetta Dejana(Swepub:uu)elide443 (författare)
McDonald, Donald M. (författare)
Uppsala universitetScience for Life Laboratory, SciLifeLab (creator_code:org_t)

Ingår i:Trends in Molecular Medicine: Elsevier27:4, s. 314-3311471-49141471-499X

Av författaren/redakt...: Claesson-Welsh, ...; Dejana, Elisabet ...; McDonald, Donald ...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Medicinska och f ...; och Cell och molekyl ...

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