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Sökning: onr:"swepub:oai:DiVA.org:uu-435886" > Sex difference and ...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004157naa a2200541 4500
001oai:DiVA.org:uu-435886
003SwePub
008210301s2021 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4358862 URI
0247 a https://doi.org/10.1097/EJA.00000000000014762 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Nijbroek, Sunny G.4 aut
2451 0a Sex difference and intra-operative tidal volume :b Insights from the LAS VEGAS study
264 1b Wolters Kluwer,c 2021
338 a print2 rdacarrier
520 a BACKGROUND One key element of lung-protective ventilation is the use of a low tidal volume (VT). A sex difference in use of low tidal volume ventilation (LTVV) has been described in critically ill ICU patients.OBJECTIVES The aim of this study was to determine whether a sex difference in use of LTVV also exists in operating room patients, and if present what factors drive this difference.DESIGN, PATIENTS AND SETTING This is a posthoc analysis of LAS VEGAS, a 1-week worldwide observational study in adults requiring intra-operative ventilation during general anaesthesia for surgery in 146 hospitals in 29 countries.MAIN OUTCOME MEASURES Women and men were compared with respect to use of LTVV, defined as VT of 8 ml kg−1 or less predicted bodyweight (PBW). A VT was deemed ‘default’ if the set VT was a round number. A mediation analysis assessed which factors may explain the sex difference in use of LTVV during intra-operative ventilation.RESULTS This analysis includes 9864 patients, of whom 5425 (55%) were women. A default VT was often set, both in women and men; mode VT was 500 ml. Median [IQR] VT was higher in women than in men (8.6 [7.7 to 9.6] vs. 7.6 [6.8 to 8.4] ml kg−1 PBW, P < 0.001). Compared with men, women were twice as likely not to receive LTVV [68.8 vs. 36.0%; relative risk ratio 2.1 (95% CI 1.9 to 2.1), P < 0.001]. In the mediation analysis, patients’ height and actual body weight (ABW) explained 81 and 18% of the sex difference in use of LTVV, respectively; it was not explained by the use of a default VT.CONCLUSION In this worldwide cohort of patients receiving intra-operative ventilation during general anaesthesia for surgery, women received a higher VT than men during intra-operative ventilation. The risk for a female not to receive LTVV during surgery was double that of males. Height and ABW were the two mediators of the sex difference in use of LTVV.TRIAL REGISTRATION The study was registered at Clinicaltrials.gov, NCT01601223
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Anestesi och intensivvård0 (SwePub)302012 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Anesthesiology and Intensive Care0 (SwePub)302012 hsv//eng
653 a Anaesthesiology and Intensive Care
653 a Anestesiologi och intensivvård
653 a Physiology
653 a Fysiologi
7001 a Hol, Liselotte4 aut
7001 a Swart, Pien4 aut
7001 a Hemmes, Sabrine N. T.4 aut
7001 a Serpa Neto, Ary4 aut
7001 a Binnekade, Jan M.4 aut
7001 a Hedenstierna, Göran,d 1941-u Uppsala universitet,Klinisk fysiologi,Hedenstiernalaboratoriet4 aut0 (Swepub:uu)goranhed
7001 a Jaber, Samir4 aut
7001 a Hiesmayr, Michael4 aut
7001 a Hollmann, Markus W.4 aut
7001 a Mills, Gary H.4 aut
7001 a Vidal Melo, Marcos F.4 aut
7001 a Putensen, Christian4 aut
7001 a Schmid, Werner4 aut
7001 a Severgnini, Paolo4 aut
7001 a Wrigge, Hermann4 aut
7001 a Gama de Abreu, Marcelo4 aut
7001 a Pelosi, Paolo4 aut
7001 a Schultz, Marcus J.4 aut
7102 a Uppsala universitetb Klinisk fysiologi4 org
7730 t European Journal of Anaesthesiologyd : Wolters Kluwerg 38:10, s. 1034-1041q 38:10<1034-1041x 0265-0215x 1365-2346
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-435886
8564 8u https://doi.org/10.1097/EJA.0000000000001476

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