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Blood pressure phen...
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Yi-Ting, Lin,1981-Uppsala universitet,Kardiologi,Molekylär epidemiologi,Klinisk epidemiologi
(författare)
Blood pressure phenotypes based on ambulatory monitoring in a general middle-aged population
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Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-437990
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-437990URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:vet swepub-contenttype
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Ämneskategori:ovr swepub-publicationtype
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BackgroundAmbulatory blood pressure monitoring (ABPM) is increasingly recommended for clinical use, but more knowledge about the prevalence and variability in ABPM-derived phenotypes in the general population is needed. We describe these parameters in the community-based Swedish CArdioPulmonary bioImage Study (SCAPIS) cohort. MethodsWe examined 5881 men and women aged 50-64 with 24-hour ABPM recordings using validated monitors. ABPM phenotypes were defined according to European guidelines. White coat hypertension was defined as elevated office BP (≥140/90 mmHg) with normal mean ambulatory BP (<135/85 mmHg in day-time, <120/70 mmHg in night-time, <130/80 mmHg over 24-h); and masked hypertension as normal office BP (<140/90 mmHg) with elevated mean ambulatory BP (≥135/85 mmHg in day-time, ≥120/70 mmHg in night-time, ≥130/80 mmHg over 24-h). Blood pressure variability was assessed using the coefficient of variation (CV), standard deviation (SD), and average real variability. ResultsBased on the ABPM recordings, 36.9% of participants had 24-h hypertension, 40.7% had day-time hypertension, and 37.6% nocturnal hypertension. Among participants treated with anti-hypertensive drugs, 1 in 3 had elevated office blood pressures, and more than half had elevated 24-h, day-time or nocturnal blood pressures. Among participants without anti-hypertensive drugs, only 1 in 6 had elevated office blood pressures, but 1 in 3 had elevated 24-h, day-time or nocturnal blood pressures. Men had higher 24-h blood pressures, more masked hypertension, but less white-coat hypertension than women. The prevalence of white-coat hypertension increased with age, but not the prevalence of masked hypertension. A positive association between blood pressure level and variability was observed, and within-person and between-person SD and CV were of similar magnitude. The variance in ABPM on repeated measurements was substantial. ConclusionIn the middle-aged general population, masked hypertension is an underappreciated problem on the population level.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Lampa, Erik,1977-Uppsala universitet,Arbets- och miljömedicin,Uppsala kliniska forskningscentrum (UCR)(Swepub:uu)erila302
(författare)
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Fall, Tove,1979-Uppsala universitet,Science for Life Laboratory, SciLifeLab,Molekylär epidemiologi,Kardiologi(Swepub:uu)tovfa878
(författare)
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Sundström, Johan,Professor,1971-Uppsala universitet,Geriatrik,Uppsala kliniska forskningscentrum (UCR),Kardiologi,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab,Klinisk epidemiologi(Swepub:uu)johasund
(författare)
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Uppsala universitetKardiologi
(creator_code:org_t)
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