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A longitudinal stud...
A longitudinal study of rural Bangladeshi children with long-term arsenic and cadmium exposures and biomarkers of cardiometabolic diseases
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- Akhtar, Evana (författare)
- Icddr B, Infect Dis Div, Dhaka 1212, Bangladesh
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- Roy, Anjan Kumar (författare)
- Icddr B, Infect Dis Div, Dhaka 1212, Bangladesh
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- Haq, Md Ahsanul (författare)
- Icddr B, Infect Dis Div, Dhaka 1212, Bangladesh
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- von Ehrenstein, Ondine S. (författare)
- Univ Calif Los Angeles, Fielding Sch Publ Hlth, Dept Community Hlth Sci & Epidemiol, Los Angeles, CA 90024 USA
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- Ahmed, Sultan (författare)
- Icddr B, Infect Dis Div, Dhaka 1212, Bangladesh
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- Vahter, Marie (författare)
- Karolinska Institutet
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- Ekström, Eva-Charlotte, 1956- (författare)
- Uppsala universitet,Internationell barnhälsa och nutrition
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- Kippler, Maria (författare)
- Karolinska Institutet
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- Wagatsuma, Yukiko (författare)
- Univ Tsukuba, Fac Med, Dept Clin Trial & Clin Epidemiol, Tsukuba, Ibaraki, Japan
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- Raqib, Rubhana (författare)
- Icddr B, Infect Dis Div, Dhaka 1212, Bangladesh
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(creator_code:org_t)
- Elsevier, 2021
- 2021
- Engelska.
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Ingår i: Environmental Pollution. - : Elsevier. - 0269-7491 .- 1873-6424. ; 271
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- There is growing interest in understanding the contribution of environmental toxicant exposure in early life to development of cardiometabolic diseases (CMD) in adulthood. We aimed to assess associations of early life exposure to arsenic and cadmium with biomarkers of CMD in children in rural Bangladesh. From a longitudinal mother-child cohort in Matlab, Bangladesh, we followed up 540 pairs. Exposure to arsenic (U–As) and cadmium (U–Cd) was assessed by concentrations in urine from mothers at gestational week 8 (GW8) and children at ages 4.5 and 9 years. Blood pressure and anthropometric indices were measured at 4.5 and 9 years. Metabolic markers (lipids, glucose, hemoglobin A1c, adipokines, estimated glomerular filtration rate (eGFR) were determined in plasma/blood of 9 years old children. In linear regression models, adjusted for child sex, age, height-for-age z score (HAZ), BMI-for-age z score (BAZ), socioeconomic status (SES) and maternal education, each doubling of maternal and early childhood U–Cd was associated with 0.73 and 0.82 mmHg increase in systolic blood pressure (SBP) respectively. Both early and concurrent childhood U–Cd was associated with diastolic (D)BP (β = 0.80 at 4.5 years; β = 0.75 at 9 years). Each doubling of U–Cd at 9 years was associated with decrements of 4.98 mg/dL of total cholesterol (TC), 1.75 mg/dL high-density lipoprotein (HDL), 3.85 mg/dL low-density lipoprotein (LDL), 0.43 mg/dL glucose and 4.29 units eGFR. Each doubling of maternal U–Cd was associated with a decrement of 1.23 mg/dL HDL. Both maternal and childhood U–As were associated with decrement in TC and HDL. Multiple comparisons were checked with family-wise error rate Bonferroni-type-approach. The negative associations of arsenic and cadmium with biomarkers of CMD in preadolescent children indicated influence of both metal(loid)s on fat and carbohydrate metabolism, while cadmium additionally influenced kidney function and BP. Thus, fewer outcomes were associated with U–As compared to U–Cd at preadolescence.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
Nyckelord
- Arsenic
- Cadmium
- Prenatal and childhood exposure
- Cardiometabolic biomarkers
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Akhtar, Evana
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Roy, Anjan Kumar
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Haq, Md Ahsanul
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von Ehrenstein, ...
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Ahmed, Sultan
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Vahter, Marie
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Ekström, Eva-Cha ...
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Kippler, Maria
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Wagatsuma, Yukik ...
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Raqib, Rubhana
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Environmental Po ...
- Av lärosätet
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Uppsala universitet
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Karolinska Institutet