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A Comparison of Gra...
A Comparison of Gray Matter Density in Restless Legs Syndrome Patients and Matched Controls Using Voxel-Based Morphometry
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- Comley, Robert A. (författare)
- GlaxoSmithKline Clin Imaging Ctr, London, England.
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- Cervenka, Simon (författare)
- Karolinska Institutet
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- Palhagen, Sven E. (författare)
- Karolinska Univ Hosp Huddinge, Dept Neurol, Stockholm, Sweden.
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- Panagiotidis, Georgios (författare)
- Karolinska Institutet
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- Matthews, Julian C. (författare)
- Univ Manchester, Sch Canc & Enabling Sci, Manchester, Lancs, England.
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- Lai, Robert Y. (författare)
- GlaxoSmithKline Inc, Discovery Med, Harlow, Essex, England.
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- Halldin, Christer (författare)
- Karolinska Institutet
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- Farde, Lars (författare)
- Karolinska Institutet
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- Nichols, Thomas E. (författare)
- Univ Warwick, Appl Neuroimaging Grp, Warwick, England.
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- Whitcher, Brandon J. (författare)
- GlaxoSmithKline Clin Imaging Ctr, London, England.
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Karolinska Institutet GlaxoSmithKline Clin Imaging Ctr, London, England (creator_code:org_t)
- 2010-11-17
- 2012
- Engelska.
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Ingår i: Journal of Neuroimaging. - : WILEY-BLACKWELL. - 1051-2284 .- 1552-6569. ; 22:1, s. 28-32
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
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- BACKGROUND Restless legs syndrome (RLS) is a common neurological disorder the pathophysiology of which is incompletely understood. Four studies have examined structural differences between the brains of RLS patients and healthy controls, using voxel-based morphometry (VBM). All 4 studies have provided different results. METHODS Optimized VBM was used to search for structural differences in gray matter density. Sixteen RLS patients naive to dopaminergic drugs and 16 age-and sex-matched controls received structural T1-weighted MR scans. Structural data were analyzed using FSL-VBM. RESULTS No difference in gray matter density was detected between the two groups (voxel-wise significance: no significant voxels at P = .89 (whole brain Family Wise Error (FWE) corrected); no significant voxels at P < .05 (whole brain False Discovery Rate (FDR) corrected; smallest achievable FDR threshold .99). CONCLUSION/DISCUSSION The present study did not replicate (confirm) previous findings of structural brain changes in RLS, but instead supported the findings of a recent study showing a lack of gray matter alteration in an elderly RLS population. More specifically, the results do not support neuronal loss as an underlying disease mechanism in RLS. Potential limitations in the application of VBM are also discussed.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- Restless legs syndrome (RLS)
- voxel-based morphometry (VBM)
- magnetic resonance imaging (MRI)
- neuroimaging
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- ref (ämneskategori)
- art (ämneskategori)
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Comley, Robert A ...
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Cervenka, Simon
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Palhagen, Sven E ...
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Panagiotidis, Ge ...
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Matthews, Julian ...
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Lai, Robert Y.
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visa fler...
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Halldin, Christe ...
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Farde, Lars
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Nichols, Thomas ...
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Whitcher, Brando ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Neurologi
- Artiklar i publikationen
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Journal of Neuro ...
- Av lärosätet
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Uppsala universitet
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Karolinska Institutet