Sökning: onr:"swepub:oai:DiVA.org:uu-447923" >
Endocrine, metaboli...
Endocrine, metabolic and apical effects of in utero and lactational exposure to non-dioxin-like 2,2 ',3,4,4 ',5,5 '-heptachlorobiphenyl (PCB 180) : A postnatal follow-up study in rats
-
- Alarcon, Sonia (författare)
- Univ Miguel Hernandez Elche, Inst Bioingn, Elche, Alicante, Spain.;Karolinska Inst, Inst Environm Med, Stockholm, Sweden
-
- Esteban, Javier (författare)
- Univ Miguel Hernandez Elche, Inst Bioingn, Elche, Alicante, Spain
-
- Roos, Robert (författare)
- Karolinska Inst, Inst Environm Med, Stockholm, Sweden.;Grand Duchy Luxembourg, Lab & Mine Inspect, Minist Work, Luxembourg, Luxembourg
-
visa fler...
-
- Heikkinen, Paivi (författare)
- Finnish Inst Hlth & Welf THL, Environm Hlth Unit, POB 95, FI-70701 Kuopio, Finland
-
- Sanchez-Perez, Ismael (författare)
- Univ Miguel Hernandez Elche, Inst Bioingn, Elche, Alicante, Spain
-
- Adamsson, Annika (författare)
- Univ Turku, Turku Univ Hosp, Inst Biomed, Dept Paediat,Res Ctr Integrat Physiol & Pharmac, FI-20520 Turku, Finland.;Univ Turku, Turku Univ Hosp, Inst Biomed, Dept Paediat,Ctr Populat Hlth Res, FI-20520 Turku, Finland,Univ Oulu, Fac Med, Res Unit Med Imaging Phys & Technol, Oulu, Finland,Vrije Univ Amsterdam, Dept Environm & Hlth, De Boelelaan 1108, NL-1081 HZ Amsterdam, Netherlands
-
- Toppari, Jorma (författare)
- Univ Turku, Turku Univ Hosp, Inst Biomed, Dept Paediat,Res Ctr Integrat Physiol & Pharmac, FI-20520 Turku, Finland.;Univ Turku, Turku Univ Hosp, Inst Biomed, Dept Paediat,Ctr Populat Hlth Res, FI-20520 Turku, Finland
-
- Koskela, Antti (författare)
- Univ Oulu, Inst Canc Res & Translat Med, Dept Anat & Cell Biol, Oulu, Finland
-
- Finnila, Mikko A. J. (författare)
- Univ Oulu, Fac Med, Res Unit Med Imaging Phys & Technol, Oulu, Finland
-
- Tuukkanen, Juha (författare)
- Univ Oulu, Inst Canc Res & Translat Med, Dept Anat & Cell Biol, Oulu, Finland
-
- Herlin, Maria (författare)
- Karolinska Inst, Inst Environm Med, Stockholm, Sweden
-
- Hamscher, Gerd (författare)
- Justus Liebig Univ, Inst Food Chem & Food Biotechnol, D-35392 Giessen, Germany
-
- Leslie, Heather A. (författare)
- Vrije Univ Amsterdam, Dept Environm & Hlth, De Boelelaan 1108, NL-1081 HZ Amsterdam, Netherlands
-
- Korkalainen, Merja (författare)
- Finnish Inst Hlth & Welf THL, Environm Hlth Unit, POB 95, FI-70701 Kuopio, Finland
-
- Halldin, Krister (författare)
- Uppsala universitet,Institutionen för kemi - BMC,Karolinska Inst, Inst Environm Med, Stockholm, Sweden
-
- Schrenk, Dieter (författare)
- Univ Kaiserslautern, Food Chem & Toxicol, D-67663 Kaiserslautern, Germany
-
- Hakansson, Helen (författare)
- Karolinska Institutet,Karolinska Inst, Inst Environm Med, Stockholm, Sweden
-
- Viluksela, Matti (författare)
- Univ Eastern Finland, Sch Pharm Toxicol, Dept Environm & Biol Sci, Kuopio, Finland.;Uppsala Univ, BMC, Off Med & Pharm, SE-75123 Uppsala, Sweden
-
visa färre...
-
Univ Miguel Hernandez Elche, Inst Bioingn, Elche, Alicante, Spain;Karolinska Inst, Inst Environm Med, Stockholm, Sweden Univ Miguel Hernandez Elche, Inst Bioingn, Elche, Alicante, Spain (creator_code:org_t)
- Elsevier, 2021
- 2021
- Engelska.
-
Ingår i: Reproductive Toxicology. - : Elsevier. - 0890-6238 .- 1873-1708. ; 102, s. 109-127
- Relaterad länk:
-
https://doi.org/10.1...
-
visa fler...
-
https://uu.diva-port... (primary) (Raw object)
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
http://kipublication...
-
visa färre...
Abstract
Ämnesord
Stäng
- PCB 180 is a persistent and abundant non-dioxin-like PCB (NDL-PCB). We determined the developmental toxicity profile of ultrapure PCB 180 in developing offspring following in utero and lactational exposure with the focus on endocrine, metabolic and retinoid system alterations. Pregnant rats were given total doses of 0, 10, 30, 100, 300 or 1000 mg PCB 180/kg bw on gestational days 7-10 by oral gavage, and the offspring were sampled on postnatal days (PND) 7, 35 and 84. Decreased serum testosterone and triiodothyronine concentrations on PND 84, altered liver retinoid levels, increased liver weights and induced 7-pentoxyresorufin O-dealkylase (PROD) activity were the sensitive effects used for margin of exposure (MoE) calculations. Liver weights were increased together with induction of the metabolizing enzymes cytochrome P450 (CYP) 2B1, CYP3A1, and CYP1A1. Less sensitive effects included decreased serum estradiol and increased luteinizing hormone levels in females, decreased prostate and seminal vesicle weight and increased pituitary weight in males, increased cortical bone area and thickness of tibial diaphysis in females and decreased cortical bone mineral density in males. Developmental toxicity profiles were partly different in male and female offspring, males being more sensitive to increased liver weight, PROD induction and decreased thyroxine concentrations. MoE assessment indicated that the 95th percentile of current maternal PCB 180 concentrations do not exceed the estimated tolerable human lipid-based PCB 180 concentration. Although PCB 180 is much less potent than dioxin-like compounds, it shares several toxicological targets suggesting a potential for interactions.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
Nyckelord
- PCB 180
- Non-dioxin-like PCBs
- Testosterone
- Thyroid hormones
- Retinoid
- Endocrine disruption
- Liver
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Alarcon, Sonia
-
Esteban, Javier
-
Roos, Robert
-
Heikkinen, Paivi
-
Sanchez-Perez, I ...
-
Adamsson, Annika
-
visa fler...
-
Toppari, Jorma
-
Koskela, Antti
-
Finnila, Mikko A ...
-
Tuukkanen, Juha
-
Herlin, Maria
-
Hamscher, Gerd
-
Leslie, Heather ...
-
Korkalainen, Mer ...
-
Halldin, Krister
-
Schrenk, Dieter
-
Hakansson, Helen
-
Viluksela, Matti
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Medicinska och f ...
-
och Farmakologi och ...
- Artiklar i publikationen
-
Reproductive Tox ...
- Av lärosätet
-
Uppsala universitet
-
Karolinska Institutet