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Air pollution and I...
Air pollution and IgE sensitization in 4 European birth cohorts : the MeDALL project
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- Melén, Erik (författare)
- Karolinska Institutet,Karolinska Inst, Dept Clin Sci & Educ, Södersjukhuset, Stockholm, Sweden; Sachs Childrens Hosp, Stockholm, Sweden
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- Standl, Marie (författare)
- German Res Ctr Environm Hlth, Inst Epidemiol, Helmholtz Zentrum Munchen, Neuherberg, Germany
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- Gehring, Ulrike (författare)
- Univ Utrecht, Inst Risk Assessment Sci, Utrecht, Netherlands
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- Altug, Hicran (författare)
- IUF Leibniz Res Inst Environm Med, Düsseldorf, Germany
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- Antó, Josep Maria (författare)
- Barcelona Inst Global Hlth, ISGlobal, Barcelona, Spain; Univ Pompeu Fabra, Barcelona, Spain; CIBER Epidemiol & Salud Publ, Madrid, Spain; Hosp Mar Med Res Inst, Barcelona, Spain
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- Berdel, Dietrich (författare)
- Marien Hosp Wesel, Res Inst, Dept Pediat, Wesel, Germany
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- Bergström, Anna (författare)
- Karolinska Institutet,Karolinska Inst, Inst Environm Med, Nobels Väg 13,Box 210, SE-17177 Stockholm, Sweden
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- Bousquet, Jean (författare)
- MACVIA France, Malad Chron Vieillissement Actif France European, Montpellier, France; INSERM U1168, VIMA Ageing & Chron Dis Epidemiol & Publ Hlth App, Villejuif, France; Univ Versailles St Quentin En Yvelines, Montigny Le Bretonneux, France
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- Heinrich, Joachim (författare)
- German Res Ctr Environm Hlth, Inst Epidemiol, Helmholtz Zentrum Munchen, Neuherberg, Germany; Ludwig Maximilians Univ Munchen, Inst & Clin Occupat Social & Environm Med, Univ Hosp, Munich, Germany; Univ Melbourne, Melbourne Sch Populat & Global Hlth, Allergy & Lung Hlth Unit, Melbourne, Vic, Australia
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- Koppelman, Gerard H. (författare)
- Univ Groningen, Univ Med Ctr Groningen, Beatrix Childrens Hosp, Dept Pediat Pulmonol & Pediat Allergol, Groningen, Netherlands; Univ Groningen, Univ Med Ctr Groningen, Groningen Res Inst Asthma & COPD GRIAC, Groningen, Netherlands
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- Kull, Inger (författare)
- Karolinska Institutet,Karolinska Inst, Dept Clin Sci & Educ, Södersjukhuset, Stockholm, Sweden; Sachs Childrens Hosp, Stockholm, Sweden
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- Lupinek, Christian (författare)
- Med Univ Vienna, Dept Pathophysiol & Allergy Res, Ctr Pathophysiol Infectiol & Immunol, Vienna, Austria
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- Markevych, Iana (författare)
- German Res Ctr Environm Hlth, Inst Epidemiol, Helmholtz Zentrum München, Neuherberg, Germany; Ludwig Maximilians Univ Munchen, Inst & Clin Occupat Social & Environm Med, Univ Hosp, Munich, Germany; Jagielonian Univ, Inst Psychol, Krakow, Poland
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- Schikowski, Tamara (författare)
- IUF Leibniz Res Inst Environm Med, Düsseldorf, Germany
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- Thiering, Elisabeth (författare)
- German Res Ctr Environm Hlth, Inst Epidemiol, Helmholtz Zentrum München, Neuherberg, Germany; Ludwig Maximilians Univ Munchen, Div Metab & Nutr Med, Dr von Hauner Childrens Hosp, Univ Hosp, Munich, Germany
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- Valenta, Rudolf (författare)
- Med Univ Vienna, Dept Pathophysiol & Allergy Res, Ctr Pathophysiol Infectiol & Immunol, Vienna, Austria; Sechenov First Moscow State Med Univ, Dept Clin Immunol & Allergy, Lab Immunopathol, Moscow, Russia; Inst Immunol FMBA Russia, Natl Res Ctr, Moscow, Russia; Karl Landsteiner Univ Hlth Sci, Krems, Austria
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- van Hage, Marianne (författare)
- Karolinska Institutet,Karolinska Inst, Dept Med Solna, Div Immunol & Allergy, Stockholm, Sweden; Karolinska Univ Hosp, Stockholm, Sweden
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- von Berg, Andrea (författare)
- Marien Hosp Wesel, Res Inst, Dept Pediat, Wesel, Germany
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- Vonk, Judith M. (författare)
- Univ Groningen, Univ Med Ctr Groningen, Groningen Res Inst Asthma & COPD GRIAC, Groningen, Netherlands; Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, Groningen, Netherlands
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- Wickman, Magnus (författare)
- Uppsala universitet,Centrum för klinisk forskning i Sörmland (CKFD)
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- Wijga, Alet (författare)
- Natl Inst Publ Hlth & Environm, Bilthoven, Netherlands
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- Gruzieva, Olena (författare)
- Karolinska Institutet,Karolinska Inst, Inst Environm Med, Nobels Väg 13, Box 210, SE-17177 Stockholm, Sweden; Ctr Occupat & Environm Med, Stockholm, Region Stockhol, Sweden
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(creator_code:org_t)
- Elsevier, 2021
- 2021
- Engelska.
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Ingår i: Journal of Allergy and Clinical Immunology. - : Elsevier. - 0091-6749 .- 1097-6825. ; 147:2, s. 713-722
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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http://www.jacionlin...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- BackgroundWhether long-term exposure air to pollution has effects on allergic sensitization is controversial.ObjectiveOur aim was to investigate associations of air pollution exposure at birth and at the time of later biosampling with IgE sensitization against common food and inhalant allergens, or specific allergen molecules, in children aged up to 16 years.MethodsA total of 6163 children from 4 European birth cohorts participating in the Mechanisms of the Development of ALLergy [MeDALL] consortium were included in this meta-analysis of the following studies: Children, Allergy, Milieu, Stockholm, Epidemiology (BAMSE) (Sweden), Influences of Lifestyle-Related Factors on the Human Immune System and Development of Allergies in Childhood (LISA)/German Infant Study on the Influence of Nutrition Intervention PLUS Environmental and Genetic Influences on Allergy Development (GINIplus) (Germany), and Prevention and Incidence of Asthma and Mite Allergy (PIAMA) (The Netherlands). The following indicators were modeled by land use regression: individual residential outdoor levels of particulate matter with aerodynamic diameters less than 2.5 μm, less than 10 μm, and between 2.5 and 10 μm; PM2.5 absorbance (a measurement of the blackness of PM2.5 filters); and nitrogen oxides levels. Blood samples drawn at ages 4 to 6 (n = 5989), 8 to 10 (n = 6603), and 15 to 16 (n = 5825) years were analyzed for IgE sensitization to allergen extracts by ImmunoCAP. Additionally, IgE against 132 allergen molecules was measured by using the MedALL microarray chip (n = 1021).ResultsAir pollution was not consistently associated with IgE sensitization to any common allergen extract up to age 16 years. However, allergen-specific analyses suggested increased risks of sensitization to birch (odds ratio [OR] = 1.12 [95% CI = 1.01-1.25] per 10-μg/m3 increase in NO2 exposure). In a subpopulation with microarray data, IgE to the major timothy grass allergen Phleum pratense 1 (Phl p 1) and the cat allergen Felis domesticus 1 (Fel d 1) greater than 3.5 Immuno Solid-phase Allergen Chip standardized units for detection of IgE antibodies were related to PM2.5 exposure at birth (OR = 3.33 [95% CI = 1.40-7.94] and OR = 4.98 [95% CI = 1.59-15.60], respectively, per 5-μg/m3 increase in exposure).ConclusionAir pollution exposure does not seem to increase the overall risk of allergic sensitization; however, sensitization to birch as well as grass pollen Phl p 1 and cat Fel d 1 allergen molecules may be related to specific pollutants.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
Nyckelord
- Allergy
- allergen
- air pollution
- children
- cohort
- IgE
- sensitization
- meta-analysis
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- Av författaren/redakt...
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Melén, Erik
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Standl, Marie
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Gehring, Ulrike
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Altug, Hicran
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Antó, Josep Mari ...
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Berdel, Dietrich
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visa fler...
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Bergström, Anna
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Bousquet, Jean
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Heinrich, Joachi ...
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Koppelman, Gerar ...
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Kull, Inger
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Lupinek, Christi ...
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Markevych, Iana
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Schikowski, Tama ...
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Thiering, Elisab ...
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Valenta, Rudolf
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van Hage, Marian ...
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von Berg, Andrea
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Vonk, Judith M.
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Wickman, Magnus
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Wijga, Alet
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Gruzieva, Olena
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Lungmedicin och ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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och Arbetsmedicin oc ...
- Artiklar i publikationen
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Journal of Aller ...
- Av lärosätet
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Uppsala universitet
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Karolinska Institutet