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The simplified foll...
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Kimby, EvaKarolinska Institutet
(författare)
The simplified follicular lymphoma PRIMA-prognostic index is useful in patients with first-line chemo-free rituximab-based therapy
- Artikel/kapitelEngelska2020
Förlag, utgivningsår, omfång ...
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2020-05-14
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WILEY,2020
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electronicrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-450622
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-450622URI
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https://doi.org/10.1111/bjh.16692DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:143682422URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Follicular lymphoma (FL) is a heterogeneous disease; therefore, reliable prognostic tools are needed to plan treatment strategies. The FL International Prognostic Index (FLIPI) was developed before the rituximab era, while the PRIMA-PI was built on rituximab chemotherapy. Our objective was to evaluate these two prognostic tools in a cohort of 291 patients with FL treated in two prospective randomised Nordic Lymphoma Group trials with rituximab +/- interferon. All patients had symptomatic/progressive disease and were previously untreated. The PRIMA-PI was prognostic for both time to treatment failure (TTF) and overall survival (OS) (log-rank P = 0 center dot 003 and P < 0 center dot 001, respectively). The PRIMA-PI high-risk identified a small group of patients with a very short TTF and OS compared to the low-risk group, with a hazard ratio (HR) of 1 center dot 90 (95% confidence interval [CI] 1 center dot 30-2 center dot 78, P = 0 center dot 001) and HR of 3 center dot 19 (95% CI 1 center dot 75-5 center dot 83, P < 0 center dot 001), respectively. The FLIPI risk groups were prognostic only for OS (log-rank P = 0 center dot 018). The simplified PRIMA-PI was valid in our FL cohort with first-line rituximab-containing chemo-free therapy and shows an improved risk stratification compared to the FLIPI, especially in patients aged >60 years. Patients in the PRIMA-PI high-risk group should be considered for alternative therapies.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Lockmer, SandraKarolinska Inst, Dept Med Huddinge, Unit Hematol, S-14186 Stockholm, Sweden.;Karolinska Univ Hosp, Unit Hematol, Stockholm, Sweden.
(författare)
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Holte, HaraldOslo Univ Hosp, Dept Oncol, Oslo, Norway.;KG Jebsen Ctr B Cell Malignancies, Oslo, Norway.
(författare)
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Hagberg, HansUppsala universitet,Experimentell och klinisk onkologi(Swepub:uu)hanshagb
(författare)
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Wahlin, Björn E.Karolinska Institutet
(författare)
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Brown, PeterRigshosp, Dept Hematol, Copenhagen, Denmark.
(författare)
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Östenstad, BjörnOslo Univ Hosp, Dept Oncol, Oslo, Norway.
(författare)
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Karolinska InstitutetKarolinska Inst, Dept Med Huddinge, Unit Hematol, S-14186 Stockholm, Sweden.;Karolinska Univ Hosp, Unit Hematol, Stockholm, Sweden.
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:British Journal of Haematology: WILEY191:5, s. 738-7470007-10481365-2141
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