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Association between...
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Enarsson, MalinKarolinska Institutet,Uppsala universitet,Centrum för klinisk forskning Dalarna
(författare)
Association between Cardiorespiratory Fitness and Circulating Proteins in 50-Year-Old Swedish Men and Women : a Cross-Sectional Study
- Artikel/kapitelEngelska2021
Förlag, utgivningsår, omfång ...
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2021-07-26
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Springer,2021
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LIBRIS-ID:oai:DiVA.org:uu-452312
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-452312URI
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https://doi.org/10.1186/s40798-021-00343-5DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:du-37870URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:147200329URI
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Språk:engelska
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Sammanfattning på:engelska
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Background and Aims: A strong cardiorespiratory fitness is suggested to have beneficial effects on cardiovascular risk; the exact mechanisms underlying the cardioprotective effects of fitness remain uncertain. Our aim was to investigate associations between cardiorespiratory fitness and multiple plasma proteins, in order to obtain insights about physiological pathways associated with the effects of exercise on cardiovascular health.Methods: In the Prospective investigation of Obesity, Energy and Metabolism (POEM) study (n=444 adults aged 50 years, 50% women), cardiorespiratory fitness was measured by a maximal exercise test on bicycle ergometer with gas exchange (VO(2)peak) normalized for body lean mass (dual-energy X-ray absorptiometry (DXA)). We measured 82 cardiovascular proteins associated with cardiovascular pathology and inflammation in plasma samples with a proximity extension assay.Results: In sex-adjusted linear regression, VO(2)peak was associated with 18 proteins after Bonferroni correction for multiple testing (p<0.0006). Following additional adjustment for fat mass (DXA), fasting glucose (mmol/L), low-density lipoprotein (LDL, mmol/L), smoking status, waist/hip ratio, blood pressure (mmHg), education level, and lpnr (lab sequence number), higher VO(2)peak was significantly associated with lower levels of 6 proteins: fatty-acid binding protein-4 (FABP4), interleukin-6 (IL-6), leptin, cystatin-B (CSTB), interleukin-1 receptor antagonist (IL-1RA), and growth differentiation factor 15 (GDF-15), and higher levels of 3 proteins: galanin, kallikrein-6 (KLK6), and heparin-binding EGF-like growth factor (HB-EGF), at nominal p-values (p<0.05).Conclusions: We identified multiple novel associations between cardiorespiratory fitness and plasma proteins involved in several atherosclerotic processes and key cellular mechanisms such as inflammation, energy homeostasis, and protease activity, which shed new light on how exercise asserts its beneficial effects on cardiovascular health. Our findings encourage additional studies in order to understand the underlying causal mechanisms for these associations.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Rudholm Feldreich, TobiasHögskolan Dalarna,Medicinsk vetenskap,Dalarna Univ, Sch Hlth & Social Studies, S-79188 Falun, Sweden.(Swepub:du)trf
(författare)
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Byberg, LiisaUppsala universitet,Medicinsk epidemiologi(Swepub:uu)liisbybe
(författare)
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Nowak, ChristophKarolinska Institutet
(författare)
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Lind, LarsUppsala universitet,Klinisk epidemiologi(Swepub:uu)larslind
(författare)
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Ärnlöv, Johan,1970-Högskolan Dalarna,Medicinsk vetenskap,Karolinska Institutet,Dalarna Univ, Sch Hlth & Social Studies, S-79188 Falun, Sweden.;Karolinska Inst, Div Family Med & Primary Care, Dept Neurobiol Care Sci & Soc NVS, Alfred Nobels Alle 23, S-14183 Huddinge, Sweden.(Swepub:du)jan
(författare)
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Uppsala universitetCentrum för klinisk forskning Dalarna
(creator_code:org_t)
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Ingår i:SPORTS MEDICINE-OPEN: Springer72199-11702198-9761
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