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Distinct plasma biomarkers confirm the diagnosis of mastocytosis and identify increased risk of anaphylaxis
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- Gülen, Theo (författare)
- Karolinska Institutet,Karolinska Univ Hosp, Dept Resp Med & Allergy, Stockholm, Sweden.;Karolinska Inst, Dept Med Huddinge, Stockholm, Sweden.;Karolinska Inst, Div Immunol & Allergy, Dept Med Solna, Stockholm, Sweden.;Karolinska Univ Hosp, Clin Immunol & Transfus Med, Stockholm, Sweden.;Karolinska Inst, Ctr Allergy Res, Stockholm, Sweden.;Karolinska Univ Hosp, Mastocytosis Ctr Karolinska, Stockholm, Sweden.;Karolinska Inst, Stockholm, Sweden.
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- Teufelberger, Andrea (författare)
- Karolinska Inst, Div Immunol & Allergy, Dept Med Solna, Stockholm, Sweden.;Karolinska Univ Hosp, Clin Immunol & Transfus Med, Stockholm, Sweden.;Karolinska Inst, Ctr Allergy Res, Stockholm, Sweden.;Karolinska Univ Hosp, Mastocytosis Ctr Karolinska, Stockholm, Sweden.;Karolinska Inst, Stockholm, Sweden.
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- Ekoff, Maria (författare)
- Karolinska Institutet,Karolinska Inst, Div Immunol & Allergy, Dept Med Solna, Stockholm, Sweden.;Karolinska Univ Hosp, Clin Immunol & Transfus Med, Stockholm, Sweden.;Karolinska Inst, Ctr Allergy Res, Stockholm, Sweden.;Karolinska Univ Hosp, Mastocytosis Ctr Karolinska, Stockholm, Sweden.;Karolinska Inst, Stockholm, Sweden.
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- Karolinska Institutet Karolinska Univ Hosp, Dept Resp Med & Allergy, Stockholm, Sweden;Karolinska Inst, Dept Med Huddinge, Stockholm, Sweden.;Karolinska Inst, Div Immunol & Allergy, Dept Med Solna, Stockholm, Sweden.;Karolinska Univ Hosp, Clin Immunol & Transfus Med, Stockholm, Sweden.;Karolinska Inst, Ctr Allergy Res, Stockholm, Sweden.;Karolinska Univ Hosp, Mastocytosis Ctr Karolinska, Stockholm, Sweden.;Karolinska Inst, Stockholm, Sweden. (creator_code:org_t)
- Elsevier, 2021
- 2021
- Engelska.
- Ingår i: Journal of Allergy and Clinical Immunology. - : Elsevier. - 0091-6749 .- 1097-6825. ; 148:3, s. 889-894
- Tidskriftsartikel (refereegranskat)
Abstract
Ämnesord
Stäng
- Background: Mastocytosis encompasses a heterogeneous group of disorders characterized by accumulation of clonal mast cells (MCs) in the skin and/or internal organs. Patients typically present with a broad variety of recurrent mediator-related clinical symptoms, including severe anaphylaxis. However, not all patients with mastocytosis experience anaphylactic reactions.Objective: We sought to identify disease-specific biomarkers in plasma that could be used to predict patients with mastocytosis with increased risk of anaphylaxis.Methods: Nineteen patients (>_18 years) and 2 control groups (11 subjects with allergic asthma and 13 healthy volunteers without history of atopy) were recruited. In total, 248 plasma proteins were analyzed by Proximity Extension Assay using Olink Proseek Multiplex panels.Results: We identified 4 novel proteins, in addition to tryptase, E-selectin, adrenomedullin, T-cell immunoglobulin, and mucin domain 1, and CUB domain-containing protein 1/CD138 to be significantly increased in patients with mastocytosis compared with both patients with asthma and healthy controls. Furthermore, we investigated whether we could discriminate between patients with mastocytosis with or without anaphylaxis. In addition to tryptase, we identified 3 novel proteins, that is, allergin-1, pregnancy-associated plasma protein-A, and galectin-3, with significantly different levels in patients with mastocytosis with anaphylaxis compared with those without anaphylaxis.Conclusions: Newly identified proteomic biomarkers may be used to predict patients with mastocytosis with increased risk of anaphylaxis.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Nyckelord
- Mastocytosis
- anaphylaxis
- tryptase
- mast cell
- plasma proteomic
- PAPP-A
- galectin-3
- allergin-1
- TPSAB1
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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