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Changes in plasma f...
Changes in plasma fatty acids and related biomarkers during transition to an exclusively plant- and fish-based diet in healthy adults
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- Alshahawy, Rasha (författare)
- Univ Kafr Elshikh, Fac Med, Dept Physiol, Kafr Elshikh, Egypt.
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- El Habachi, Nihal (författare)
- Alexandria Univ, Alexandria Clin Res Ctr, Alexandria, Egypt.;Univ Alexandria, Fac Med, Dept Physiol, Alexandria, Egypt.
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- Allam, Eman (författare)
- Univ Alexandria, Fac Med, Dept Physiol, Alexandria, Egypt.
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- Jernerén, Fredrik (författare)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Univ Oxford, Dept Pharmacol, Oxford, England.
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- Refsum, Helga (författare)
- Univ Oxford, Dept Pharmacol, Oxford, England.;Univ Oslo, Inst Basic Med Sci, Dept Nutr, Oslo, Norway.
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- Elshorbagy, Amany (författare)
- Univ Alexandria, Fac Med, Dept Physiol, Alexandria, Egypt.;Univ Oxford, Dept Pharmacol, Oxford, England.
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Univ Kafr Elshikh, Fac Med, Dept Physiol, Kafr Elshikh, Egypt Alexandria Univ, Alexandria Clin Res Ctr, Alexandria, Egypt.;Univ Alexandria, Fac Med, Dept Physiol, Alexandria, Egypt. (creator_code:org_t)
- Elsevier, 2021
- 2021
- Engelska.
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Ingår i: Nutrition. - : Elsevier. - 0899-9007 .- 1873-1244. ; 90
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Objective: The aim of this study was to examine the time scale of plasma fatty acid changes during transition to an exclusively plant- and fish-based diet in healthy individuals and determine whether there are associated alterations in arachidonic acid (ARA)-derived inflammatory mediators, estimated stearoyl coenzyme A desaturase (SCD) activity, and blood pressure. Methods: In pursuit of a religious fast, 36 adults abstained from eating poultry, meat, dairy products, and eggs, while increasing fish intake for 6 wk. Participants were assessed 1 wk before (W0) and 1 (WI) and 6 (W6) weeks after the diet change. Results: By W6, fasting plasma long-chain omega-3 polyunsaturated fatty acids (omega-3 LC-PUFAs); docosahexaenoic (DHA) and eicosapentaenoic (EPA) had increased (+67% and +73%, respectively; P <= 0.001), with early rise of DHA (+22%), but not EPA at W1.The omega-3 index (sum of DHA and EPA as a percent of total fatty acids) increased from 2.1% to 3.4%. ARA decreased progressively (W1, -9%; W6, -16%; P < 0.001). ARA precursors gamma-linolenic and dihomo-gamma-linolenic acids also decreased, without changes in the ARA-derived mediators prostaglandin-E2 and leukotriene-B4. Myristic acid decreased at W1 (-37%) and W6 (-40%). There was no consistent change in SCD indices. At W6, systolic and diastolic blood pressure had declined by 8 and 5 mm Hg, respectively (P <= 0.013). Conclusions: Shifting to a plant- and fish-based diet produces rapid and sustained increases in omega-3 LC-PUFAs and decreases the omega-6 PUFA ARA and its precursors, consistent with a cardio-protective profile. The rapid response suggests that these biomarkers may be useful for assessment of diet interventions.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Nyckelord
- Fatty acid profile
- Fasting
- Cardiovascular disease
- Polyunsaturated fatty acids
- Inflammatory mediators
- Blood pressure
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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