Sökning: onr:"swepub:oai:DiVA.org:uu-457447" >
Persistence and adh...
Persistence and adherence to non-vitamin K antagonist oral anticoagulant treatment in patients with atrial fibrillation across five Western European countries
-
- Komen, Joris J (författare)
- Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute of Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands;Department of Healthcare Development, Stockholm Region, Public Healthcare Services Committee, Stockholm, Sweden
-
- Pottegård, Anton (författare)
- Clinical Pharmacology and Pharmacy, Department of Public Health, University of Southern Denmark, Odense, Denmark
-
- Mantel-Teeuwisse, Aukje K (författare)
- Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute of Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
-
visa fler...
-
- Forslund, Tomas (författare)
- Karolinska Institutet,Department of Healthcare Development, Stockholm Region, Public Healthcare Services Committee, Stockholm, Sweden;Department of Medicine Solna, Clinical Epidemiology/Clinical Pharmacology, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden
-
- Hjemdahl, Paul (författare)
- Karolinska Institutet,Department of Medicine Solna, Clinical Epidemiology/Clinical Pharmacology, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden
-
- Wettermark, Björn (författare)
- Karolinska Institutet,Uppsala universitet,Institutionen för farmaci,Pharmacoepidemiology
-
- Hellfritzsch, Maja (författare)
- Clinical Pharmacology and Pharmacy, Department of Public Health, University of Southern Denmark, Odense, Denmark;Department of Clinical Pharmacology, Aarhus University Hospital, Aarhus, Denmark
-
- Hallas, Jesper (författare)
- Clinical Pharmacology and Pharmacy, Department of Public Health, University of Southern Denmark, Odense, Denmark
-
- Olesen, Morten (författare)
- Clinical Pharmacology and Pharmacy, Department of Public Health, University of Southern Denmark, Odense, Denmark
-
- Bennie, Marion (författare)
- Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK;Public Health and Intelligence Strategic Business Unit, NHS National Services Scotland, Glasgow, UK
-
- Mueller, Tanja (författare)
- Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK
-
- Voss, Annemarie (författare)
- Department of Clinical Epidemiology, Leibniz Institute for Prevention Research and Epidemiology—BIPS, Bremen, Germany
-
- Schink, Tania (författare)
- Department of Clinical Epidemiology, Leibniz Institute for Prevention Research and Epidemiology—BIPS, Bremen, Germany
-
- Haug, Ulrike (författare)
- Department of Clinical Epidemiology, Leibniz Institute for Prevention Research and Epidemiology—BIPS, Bremen, Germany;Faculty of Human and Life Sciences, University of Bremen, Bremen, Germany
-
- Kollhorst, Bianca (författare)
- Department of Biometry and Data Management, Leibniz Institute for Prevention Research and Epidemiology—BIPS, Bremen, Germany
-
- Karlstad, Øystein (författare)
- Chronic Diseases and Ageing, Division of Mental and Physical Health, Norwegian Institute of Public Health, Oslo, Norway
-
- Kjerpeseth, Lars J (författare)
- Chronic Diseases and Ageing, Division of Mental and Physical Health, Norwegian Institute of Public Health, Oslo, Norway
-
- Klungel, Olaf H (författare)
- Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute of Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands;Clinical Pharmacology and Pharmacy, Department of Public Health, University of Southern Denmark, Odense, Denmark
-
Karlstad, O (författare)
-
visa färre...
-
(creator_code:org_t)
- 2021-06-07
- 2021
- Engelska.
-
Ingår i: Europace. - : Oxford University Press. - 1099-5129 .- 1532-2092. ; 23:11, s. 1722-1730
- Relaterad länk:
-
https://doi.org/10.1...
-
visa fler...
-
https://uu.diva-port... (primary) (Raw object)
-
https://academic.oup...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
http://kipublication...
-
visa färre...
Abstract
Ämnesord
Stäng
- AimsTo assess persistence and adherence to non-vitamin K antagonist oral anticoagulant (NOAC) treatment in patients with atrial fibrillation (AF) in five Western European healthcare settings.Methods and resultsWe conducted a multi-country observational cohort study, including 559 445 AF patients initiating NOAC therapy from Stockholm (Sweden), Denmark, Scotland, Norway, and Germany between 2011 and 2018. Patients were followed from their first prescription until they switched to a vitamin K antagonist, emigrated, died, or the end of follow-up. We measured persistence and adherence over time and defined adequate adherence as medication possession rate ≥90% among persistent patients only.ResultsOverall, persistence declined to 82% after 1 year and to 63% after 5 years. When including restarters of NOAC treatment, 85% of the patients were treated with NOACs after 5 years. The proportion of patients with adequate adherence remained above 80% throughout follow-up. Persistence and adherence were similar between countries and was higher in patients starting treatment in later years. Both first year persistence and adherence were lower with dabigatran (persistence: 77%, adherence: 65%) compared with apixaban (86% and 75%) and rivaroxaban (83% and 75%) and were statistically lower after adjusting for patient characteristics. Adherence and persistence with dabigatran remained lower throughout follow-up.ConclusionPersistence and adherence were high among NOAC users in five Western European healthcare settings and increased in later years. Dabigatran use was associated with slightly lower persistence and adherence compared with apixaban and rivaroxaban.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- Physiology (medical)
- Cardiology and Cardiovascular Medicine
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
-
Europace
(Sök värdpublikationen i LIBRIS)
Till lärosätets databas
- Av författaren/redakt...
-
Komen, Joris J
-
Pottegård, Anton
-
Mantel-Teeuwisse ...
-
Forslund, Tomas
-
Hjemdahl, Paul
-
Wettermark, Björ ...
-
visa fler...
-
Hellfritzsch, Ma ...
-
Hallas, Jesper
-
Olesen, Morten
-
Bennie, Marion
-
Mueller, Tanja
-
Voss, Annemarie
-
Schink, Tania
-
Haug, Ulrike
-
Kollhorst, Bianc ...
-
Karlstad, Øystei ...
-
Kjerpeseth, Lars ...
-
Klungel, Olaf H
-
Karlstad, O
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Kardiologi
- Artiklar i publikationen
-
Europace
- Av lärosätet
-
Uppsala universitet
-
Karolinska Institutet