Semicarbazide-sensitive Amine Oxidase (SSAO) – Regulation and Involvement in Blood Vessel Damage with Special Regard to Diabetes: A Study on Mice Overexpressing Human SSAO

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Göktürk, Camilla,1967-Uppsala universitet,Institutionen för neurovetenskap (författare)

Semicarbazide-sensitive Amine Oxidase (SSAO) – Regulation and Involvement in Blood Vessel Damage with Special Regard to Diabetes : A Study on Mice Overexpressing Human SSAO

BokEngelska2004

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Uppsala :Acta Universitatis Upsaliensis,2004
54 s.
electronicrdacarrier

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LIBRIS-ID:oai:DiVA.org:uu-4673
ISBN:9155460984
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4673URI

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Språk:engelska
Sammanfattning på:engelska

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Ämneskategori:vet swepub-contenttype
Ämneskategori:dok swepub-publicationtype

Serie

Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine,0282-7476 ;1391

Anmärkningar

Semicarbazide-sensitive amine oxidase (SSAO, EC 1.4.3.6) belongs to a family of copper-containing amine oxidases. SSAO exists as a membrane bound protein in endothelial-, smooth muscle-, and adipose cells as well as soluble in plasma. SSAO catalyses oxidative deamination of primary monoamines, which results in the production of corresponding aldehydes, hydrogen peroxide and ammonia. These compounds are very reactive and potentially cytotoxic, and are able to induce vascular damage if produced in high levels. Patients with diabetes mellitus, and with diabetic complications in particular, have a higher SSAO activity in plasma compared to healthy controls. It has therefore been speculated that high SSAO activity is involved in the development of vascular complications associated with diabetes. The aim of this thesis is to investigate the importance of SSAO in the development of disorders of a vascular origin. We have studied the transcriptional regulation of the SSAO gene, by inducing diabetes in NMRI and in transgenic mice, overexpressing the human form of SSAO in smooth muscle cells. We found that the increase in SSAO activity in diabetes is accompanied by reduced mRNA levels of the endogenous mouse gene, suggesting a negative feedback on the transcription of the SSAO gene. In addition, the transgenic mice exhibited an abnormal phenotype in the elastic tissue of aorta and renal artery. These mice have a lower mean artery pressure and an elevated pulse pressure. These results indicate that high SSAO activity in smooth muscle cells is associated with a change in the morphology of large arteries. This is likely contributing to the development of vascular complications in diabetes.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Farmakologi och toxikologi hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Pharmacology and Toxicology hsv//eng
Pharmacology
amine oxidases
VAP-1
vascular complications
diabetes
blood pressure
Farmakologi
Pharmacological research
Farmakologisk forskning

Biuppslag (personer, institutioner, konferenser, titlar ...)

Oreland, Lars (preses)
Forsberg-Nilsson, Karin (preses)
Larhammar, Dan (preses)
Yu, Peter,ProfessorNeuro Psychiatry Research Unit, Saskatchewan, Canada (opponent)
Uppsala universitetInstitutionen för neurovetenskap (creator_code:org_t)

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