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SLC38A10 knockout m...
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Lindberg, Frida A.Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Molecular Neuropharmacology
(författare)
SLC38A10 knockout mice display a decreased body weight and an increased risk-taking behavior in the open field test
- Artikel/kapitelEngelska2022
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2022-05-23
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Frontiers Media S.A.2022
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electronicrdacarrier
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LIBRIS-ID:oai:DiVA.org:uu-473275
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-473275URI
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https://doi.org/10.3389/fnbeh.2022.840987DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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The solute carrier 38 family (SLC38) is a family of 11 members. The most commonsubstrate among these are alanine and glutamine, and members are present in a widerange of tissues with important functions for several biological processes, such as liverand brain function. Some of these transporters are better characterized than others and,in this paper, a behavioral characterization of SLC38A10−/− mice was carried out. Abattery of tests for general activity, emotionality, motor function, and spatial memorywere used. Among these tests, the elevated plus maze, Y-maze, marble burying, andchallenging beamwalk have not been tested on the SLC38A10−/− mice previously, whilethe open field and the rotarod tests have been performed by the International MousePhenotyping Consortium (IMPC). Unlike the results from IMPC, the results from this studyshowed that SLC38A10−/− mice spend less time in the wall zone in the open field testthan WT mice, implying that SLC38A10-deficient mice have an increased explorativebehavior, which suggests an important function of SLC38A10 in brain. The present studyalso confirmed IMPC’s data regarding rotarod performance and weight, showing thatSLC38A10−/− mice do not have an affected motor coordination impairment and havea lower body weight than both SLC38A10+/− and SLC38A10+/+ mice. These resultsimply that a complete deficiency of the SLC38A10 protein might affect body weighthomeostasis, but the underlying mechanisms needs to be studied further.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Nordin, KarinUppsala universitet,Institutionen för farmaceutisk biovetenskap,Centrum för forsknings- och bioetik,Molecular Neuropharmacology(Swepub:uu)karinord
(författare)
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Fredriksson, RobertUppsala universitet,Institutionen för farmaceutisk biovetenskap,Molecular Neuropharmacology(Swepub:uu)rfr20930
(författare)
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Uppsala universitetInstitutionen för farmaceutisk biovetenskap
(creator_code:org_t)
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Ingår i:Frontiers in Behavioral Neuroscience: Frontiers Media S.A.161662-5153
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