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ECO :
ECO : An Integrated Gene Expression Omnibus for Mouse Endothelial Cells In Vivo
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- Deng, Xiangyi (författare)
- Tianjin Med Univ, Key Lab Postneuroinjury Neurorepair & Regenerat C, Minist Educ & Tianjin City, Dept Neurosurg,Tianjin Neurol Inst,Gen Hosp, Tianjin, Peoples R China.
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- Yang, Fan (författare)
- Tianjin Med Univ, Key Lab Postneuroinjury Neurorepair & Regenerat C, Minist Educ & Tianjin City, Dept Neurosurg,Tianjin Neurol Inst,Gen Hosp, Tianjin, Peoples R China.
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- Zhang, Lei (författare)
- Shaanxi Normal Univ, Natl Engn Lab Resource Developing Endangered Chin, Minist Educ Med Plant Resource & Nat Pharmaceut C, Key Lab,Coll Life Sci, Xian, Peoples R China.
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- Wang, Jianhao (författare)
- Tianjin Med Univ, Key Lab Postneuroinjury Neurorepair & Regenerat C, Minist Educ & Tianjin City, Dept Neurosurg,Tianjin Neurol Inst,Gen Hosp, Tianjin, Peoples R China.
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- Liu, Boxuan (författare)
- Second Peoples Hosp Huaihua, Precis Med Ctr, Huaihua, Peoples R China.
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- Liang, Wei (författare)
- Second Peoples Hosp Huaihua, Precis Med Ctr, Huaihua, Peoples R China.
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- Tang, Jiefu (författare)
- Hunan Univ Med, Affiliated Hosp 1, Trauma Ctr, Huaihua, Peoples R China.
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- Xie, Yuan (författare)
- Shaanxi Normal Univ, Natl Engn Lab Resource Developing Endangered Chin, Minist Educ Med Plant Resource & Nat Pharmaceut C, Key Lab,Coll Life Sci, Xian, Peoples R China.
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- He, Liqun (författare)
- Uppsala universitet,Vaskulärbiologi,Tianjin Med Univ, Key Lab Postneuroinjury Neurorepair & Regenerat C, Minist Educ & Tianjin City, Dept Neurosurg,Tianjin Neurol Inst,Gen Hosp, Tianjin, Peoples R China.
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Tianjin Med Univ, Key Lab Postneuroinjury Neurorepair & Regenerat C, Minist Educ & Tianjin City, Dept Neurosurg,Tianjin Neurol Inst,Gen Hosp, Tianjin, Peoples R China Shaanxi Normal Univ, Natl Engn Lab Resource Developing Endangered Chin, Minist Educ Med Plant Resource & Nat Pharmaceut C, Key Lab,Coll Life Sci, Xian, Peoples R China. (creator_code:org_t)
- 2022-03-04
- 2022
- Engelska.
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Ingår i: Frontiers in Genetics. - : Frontiers Media S.A.. - 1664-8021. ; 13
- Relaterad länk:
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https://doi.org/10.3...
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https://uu.diva-port... (primary) (Raw object)
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https://www.frontier...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Endothelial cell (EC) plays critical roles in vascular physiological and pathological processes. With the development of high-throughput technologies, transcriptomics analysis of EC has increased dramatically and a large amount of informative data have been generated. The dynamic patterns of gene expression in ECs under various conditions were revealed. Unfortunately, due to the lack of bioinformatics infrastructures, reuse of these large-scale datasets is challenging for many scientists. Here, by systematic re-analyzing, integrating, and standardizing of 203 RNA sequencing samples from freshly isolated mouse ECs under 71 conditions, we constructed an integrated mouse EC gene expression omnibus (ECO). The ECO database enables one-click retrieval of endothelial expression profiles from different organs under different conditions including disease models, genetic modifications, and clinically relevant treatments in vivo. The EC expression profiles are visualized with user-friendly bar-plots. It also provides a convenient search tool for co-expressed genes. ECO facilitates endothelial research with an integrated tool and resource for transcriptome analysis. The ECO database is freely available at https://heomics. shinyapps.io/ecodb/.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Nyckelord
- endothelial cells
- gene expression
- RNAseq
- database
- integration
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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