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Cerebrospinal Fluid...
Cerebrospinal Fluid in Classical Trigeminal Neuralgia : An Exploratory Study on Candidate Biomarkers
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- Svedung-Wettervik, Teodor (författare)
- Uppsala universitet,Neurokirurgi
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- Folkvaljon, Dick (författare)
- Uppsala universitet,Neurokirurgi
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- Gordh, Torsten (författare)
- Uppsala universitet,Anestesiologi och intensivvård,Klinisk smärtforskning
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- Freyhult, Eva, 1979- (författare)
- Uppsala universitet,Beräkningsbiologi och bioinformatik
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- Kultima, Kim (författare)
- Uppsala universitet,Klinisk kemi
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- Ericson, Hans, 1959- (författare)
- Uppsala universitet,Neurokirurgi
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- Abu Hamdeh, Sami (författare)
- Uppsala universitet,Neurokirurgi
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(creator_code:org_t)
- 2022-04-26
- 2022
- Engelska.
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Ingår i: Biomedicines. - : MDPI AG. - 2227-9059. ; 10:5
- Relaterad länk:
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https://doi.org/10.3...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Background: Trigeminal neuralgia (TN) is a severe type of facial pain. A neurovascular conflict between cranial nerve V and a nearby vessel is the main pathophysiological mechanism, but additional factors are likely necessary to elicit TN. In this study, the primary aim was to explore differences in protein expression in the cerebrospinal fluid (CSF) of TN patients in relation to controls.Methods: Sixteen TN patients treated with microvascular decompression and 16 control patients undergoing spinal anesthesia for urological conditions were included. Lumbar CSF was collected preoperatively for the TN patients and before spinal anesthesia for the controls. A multiplexed proximity extension analysis of 91 CSF proteins was conducted using Proseek Multiplex Development 96, including biomarkers of cell communication, cell death, neurogenesis, and inflammationResults: The TN patients and the controls were of similar age, sex, and burden of co-morbidities. The TN patients exhibited higher concentrations of Clec11a, LGMN, MFG-E8, and ANGPTL-4 in CSF than the controls (q < 0.05).Conclusions: TN patients exhibited increased CSF biomarkers indicative of peripheral demyelinating injury (Clec11a), immune tolerance and destruction of myelin (LGMN), neuronal cell death (MFG-E8), and disturbances in myelin clearance (ANGPTL-8). Our findings are hypothesis-generating for candidate biomarkers and pathophysiological processes in classical TN.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- cerebrospinal fluid
- demyelination
- neuroinflammation
- trigeminal neuralgia
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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