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Post-Treatment Neck...
Post-Treatment Neck Dissection of Tonsillar and Base of Tongue Squamous Cell Carcinoma in the Era of PET-CT, HPV, and p16
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- Landin, David (författare)
- Karolinska Institutet,Karolinska Inst, Karolinska Univ Hosp, Dept Clin Sci, Dept Otorhinolaryngol Head & Neck Surg, S-17164 Stockholm, Sweden.;Karolinska Univ Hosp, Med Unit Head Neck Lung & Skin Canc, S-17164 Stockholm, Sweden.
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- Näsman, Anders (författare)
- Karolinska Institutet,Karolinska Inst, Dept Oncol, Pathol, S-17164 Stockholm, Sweden.;Karolinska Univ Hosp, Dept Clin Pathol, S-17164 Stockholm, Sweden.
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- Jara, Sara Jonmarker (författare)
- Karolinska Univ Hosp, Dept Neuroradiol, S-17164 Stockholm, Sweden.
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- Hammarstedt-Nordenvall, Lalle (författare)
- Karolinska Institutet,Karolinska Inst, Karolinska Univ Hosp, Dept Clin Sci, Dept Otorhinolaryngol Head & Neck Surg, S-17164 Stockholm, Sweden.;Karolinska Univ Hosp, Med Unit Head Neck Lung & Skin Canc, S-17164 Stockholm, Sweden.
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- Munck-Wikland, Eva (författare)
- Karolinska Inst, Karolinska Univ Hosp, Dept Clin Sci, Dept Otorhinolaryngol Head & Neck Surg, S-17164 Stockholm, Sweden.;Karolinska Univ Hosp, Med Unit Head Neck Lung & Skin Canc, S-17164 Stockholm, Sweden.
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- Dalianis, Tina (författare)
- Karolinska Institutet,Karolinska Inst, Dept Oncol, Pathol, S-17164 Stockholm, Sweden.
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- Marklund, Linda (författare)
- Karolinska Institutet,Uppsala universitet,Öron-, näs- och halssjukdomar,Karolinska Inst, Karolinska Univ Hosp, Dept Clin Sci, Dept Otorhinolaryngol Head & Neck Surg, S-17164 Stockholm, Sweden.;Karolinska Univ Hosp, Med Unit Head Neck Lung & Skin Canc, S-17164 Stockholm, Sweden.
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Karolinska Institutet Karolinska Inst, Karolinska Univ Hosp, Dept Clin Sci, Dept Otorhinolaryngol Head & Neck Surg, S-17164 Stockholm, Sweden;Karolinska Univ Hosp, Med Unit Head Neck Lung & Skin Canc, S-17164 Stockholm, Sweden. (creator_code:org_t)
- 2022-07-30
- 2022
- Engelska.
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Ingår i: Viruses. - : MDPI. - 1999-4915. ; 14:8
- Relaterad länk:
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https://doi.org/10.3...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.3...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Human-papillomavirus (HPV)-positive tonsillar and base of tongue carcinomas (TSCC/BOTSCC) are rising in incidence and treatments with radiotherapy, chemoradiotherapy (RT/CRT), and neck dissections (NDs) have several side effects. Therefore, an improved selection of patients needing salvage NDs would be beneficial. We examined the prevalence and localisations of viable tumour cells in neck lymph nodes in patients post-RT/CRT, identified by fluorodeoxyglucose positron-emission tomography with computer-tomography (FDG PET-CT), with a focus on HPV-associated tumours. Patients with 217 TSCC/BOTSCC with tumours assessed for HPV-DNA and p16(INK4a) undergoing FDG PET-CT 12 weeks after treatment and/or an ND were included. The FDG PET-CT data were compared with the findings in the pathology report after the ND. In total, 36/217 (17%) patients were selected for an ND due to positive findings in post-treatment FDG PET-CT. Of these, 35/36 were HPV-associated, 10/36 (28%) had viable tumour cells in the pathology reports of the neck specimen, and 8/10 (80%) were consistent with the FDG PET-CT findings, while 2/36 (5%) were missed by FDG PET-CT. We conclude that FDG PET-CT 12 weeks after RT/CRT is useful, but not completely reliable for finding all the metastases of HPV-associated TSCC/BOTSCC. Nonetheless, our data indicate that an ND could be more selectively guided by FDG PET-CT.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Nyckelord
- tonsillar squamous cell carcinoma
- base of tongue squamous cell carcinoma
- oropharyngeal squamous cell carcinoma
- human papillomavirus
- PET-CT
- metastasis
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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