SwePub
Sök i LIBRIS databas

  Utökad sökning

onr:"swepub:oai:DiVA.org:uu-485480"
 

Sökning: onr:"swepub:oai:DiVA.org:uu-485480" > Joint Exposure to P...

  • Sun, YingShanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Sch Med, Inst & Dept Endocrinol & Metab, Shanghai 200011, Peoples R China. (författare)

Joint Exposure to Positive Affect, Life Satisfaction, Depressive Symptoms, and Neuroticism and Incident Type 2 Diabetes

  • Artikel/kapitelEngelska2022

Förlag, utgivningsår, omfång ...

  • 2022-05-12
  • The Endocrine Society,2022
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-485480
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-485480URI
  • https://doi.org/10.1210/clinem/dgac304DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:149711846URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Context Whether the psychological wellbeing status could be a risk factor for type 2 diabetes is unclear. Objective We aimed to measure the association between combined psychological wellbeing factors and type 2 diabetes and investigate whether this association was modified by genetic predisposition. Methods Prospective cohort study from the UK Biobank. In total, 127 496 participants who completed a psychological wellbeing questionnaire and did not have type 2 diabetes at baseline (2006-2010) were included; among them, 88 584 (69.5%) were analyzed to determine their genetic predisposition. The main outcome measure was incident type 2 diabetes. Results During the median follow-up of 10.0 years, 2547 incident type 2 diabetes cases were documented. Moderate to extreme unhappiness, satisfaction score <= 3, presence of broad depression, and a neuroticism score >= 3 were all significantly and independently associated with an increased risk of diabetes. When considered as a combination indicator, compared with individuals in the highest quartile of the psychological wellbeing score, the fully adjusted hazard ratios (95% CI) of type 2 diabetes were 1.41 (1.21-1.65) in the third quartile, 1.45 (1.24-1.69) in the second quartile, and 1.73 (1.48-2.01) in the lowest quartile. In the stratified analysis, we observed significant interactions between age and physical activity, and type 2 diabetes (P-interaction < .001 and 0.049, respectively). However, there was no significant interaction between the psychological wellbeing score and genetic susceptibility to diabetes (P-interaction = .980). Conclusion Worse overall psychological wellbeing was associated with a significantly increased risk of type 2 diabetes in a dose-response fashion regardless of genetic predisposition.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Yu, YuefengShanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Sch Med, Inst & Dept Endocrinol & Metab, Shanghai 200011, Peoples R China. (författare)
  • Zhang, HaojieShanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Sch Med, Inst & Dept Endocrinol & Metab, Shanghai 200011, Peoples R China. (författare)
  • Wang, BinShanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Sch Med, Inst & Dept Endocrinol & Metab, Shanghai 200011, Peoples R China. (författare)
  • Chen, ChiShanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Sch Med, Inst & Dept Endocrinol & Metab, Shanghai 200011, Peoples R China. (författare)
  • Wang, YuyingShanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Sch Med, Inst & Dept Endocrinol & Metab, Shanghai 200011, Peoples R China. (författare)
  • Tan, XiaoKarolinska Institutet,Uppsala universitet,Institutionen för neurovetenskap,Karolinska Inst, Dept Clin Neurosci, Solna, Sweden.(Swepub:uu)xzata683 (författare)
  • Zhang, JihuiGuangdong Acad Med Sci, Guangdong Prov Peoples Hosp, Guangdong Mental Hlth Ctr, Guangzhou, Guangdong, Peoples R China. (författare)
  • Chen, YiShanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Sch Med, Inst & Dept Endocrinol & Metab, Shanghai 200011, Peoples R China. (författare)
  • Xia, FangzhenShanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Sch Med, Inst & Dept Endocrinol & Metab, Shanghai 200011, Peoples R China. (författare)
  • Lu, YingliShanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Sch Med, Inst & Dept Endocrinol & Metab, Shanghai 200011, Peoples R China. (författare)
  • Wang, NingjianShanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Sch Med, Inst & Dept Endocrinol & Metab, Shanghai 200011, Peoples R China. (författare)
  • Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Sch Med, Inst & Dept Endocrinol & Metab, Shanghai 200011, Peoples R China.Institutionen för neurovetenskap (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Journal of Clinical Endocrinology and Metabolism: The Endocrine Society107:8, s. E3186-E31930021-972X1945-7197

Internetlänk

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy