Sökning: onr:"swepub:oai:DiVA.org:uu-487661" >
Associations of Ear...
-
Wu, ChuanshaWuhan Univ Sci & Technol, Med Coll, Sch Publ Hlth, Dept Environm Hyg & Occupat Med, Wuhan, Peoples R China.;Wuhan Univ Sci & Technol, Hubei Prov Key Lab Occupat Hazard Identificat & C, Wuhan, Peoples R China.
(författare)
Associations of Early-Life Exposure to Submicron Particulate Matter With Childhood Asthma and Wheeze in China
- Artikel/kapitelEngelska2022
Förlag, utgivningsår, omfång ...
-
2022-10-11
-
American Medical Association (AMA),2022
-
electronicrdacarrier
Nummerbeteckningar
-
LIBRIS-ID:oai:DiVA.org:uu-487661
-
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-487661URI
-
https://doi.org/10.1001/jamanetworkopen.2022.36003DOI
Kompletterande språkuppgifter
-
Språk:engelska
-
Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
-
Ämneskategori:ref swepub-contenttype
-
Ämneskategori:art swepub-publicationtype
Anmärkningar
-
IMPORTANCE Exposure to particulate matter (PM) has been associated with childhood asthma and wheeze. However, the specific associations between asthma and PM with an aerodynamic equivalent diameter of 1 mu m or less (ie, PM1), which is a contributor to PM2.5 and potentially more toxic than PM2.5, remain unclear. OBJECTIVE To investigate the association of early-life (prenatal and first year) exposure to size-segregated PM, including PM1, PM1-2.5, PM2.5, PM2.5-10, and PM10, with childhood asthma and wheeze. DESIGN, SETTING, AND PARTICIPANTS This cross-sectional study was based on a questionnaire administered between June 2019 and June 2020 to caregivers of children aged 3 to 6 years in 7 Chinese cities (Wuhan, Changsha, Taiyuan, Nanjing, Shanghai, Chongqing, and Urumqi) as the second phase of the China, Children, Homes, Health study. EXPOSURES Exposure to PM1, PM1-2.5, PM2.5, PM2.5-10, and PM10 during the prenatal period and first year of life. MAIN OUTCOMES AND MEASURES The main outcomes were caregiver-reported childhood asthma and wheeze. A machine learning-based space-time model was applied to estimate early-life PM1, PM2.5, and PM10 exposure at 1 x 1-km resolution. Concentrations of PM1-2.5 and PM2.5-10 were calculated by subtracting PM1 from PM2.5 and PM2.5 from PM10, respectively. Multilevel (city and child) logistic regression models were applied to assess associations. RESULTS Of 29 418 children whose caregivers completed the survey (15 320 boys [52.1%]; mean [SD] age, 4.9 [0.9] years), 2524 (8.6%) ever had wheeze and 1161 (3.9%) were diagnosed with asthma. Among all children, 18 514 (62.9%) were breastfed for more than 6 months and 787 (2.7%) had parental history of atopy. A total of 22 250 children (75.6%) had a mother with an educational level of university or above. Of the 25 422 children for whom information about cigarette smoking exposure was collected, 576 (2.3%) had a mother who was a current or former smoker during pregnancy and 7525 (29.7%) had passive household cigarette smoke exposure in early life. Early-life PM1, PM2.5, and PM10 exposure were significantly associated with increased risk of childhood asthma, with higher estimates per 10-mu g/m(3) increase in PM1 (OR, 1.55; 95% CI, 1.27-1.89) than in PM2.5 (OR, 1.14; 95% CI, 1.03-1.26) and PM10 (OR, 1.11; 95% CI, 1.02-1.20). No association was observed between asthma and PM1-2.5 exposure, suggesting that PM1 rather than PM1-2.5 contributed to the association between PM2.5 and childhood asthma. There were significant associations between childhood wheeze and early-life PM1 exposure (OR, 1.23; 95% CI, 1.07-1.41) and PM2.5 exposure (OR, 1.08; 95% CI, 1.01-1.16) per 10-mu g/m(3) increase in PM1 and PM2.5, respectively. CONCLUSIONS AND RELEVANCE In this cross-sectional study, higher estimates were observed for the association between PM with smaller particles, such as PM1, vs PM with larger particles and childhood asthma. The results suggest that the association between PM2.5 and childhood asthma was mainly attributable to PM1.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Zhang, YunquanWuhan Univ Sci & Technol, Hubei Prov Key Lab Occupat Hazard Identificat & C, Wuhan, Peoples R China.;Wuhan Univ Sci & Technol, Med Coll, Sch Publ Hlth, Dept Epidemiol & Biostat, Wuhan, Peoples R China.
(författare)
-
Wei, JingUniv Iowa, Iowa Technol Inst, Dept Chem & Biochem Engn, Iowa City, IA USA.
(författare)
-
Zhao, ZhuohuiFudan Univ, Sch Publ Hlth, Dept Environm Hlth, Shanghai, Peoples R China.
(författare)
-
Norbäck, DanUppsala universitet,Institutionen för medicinska vetenskaper(Swepub:uu)dagnorba
(författare)
-
Zhang, XinShanxi Univ, Res Ctr Environm Sci & Engn, Taiyuan, Peoples R China.
(författare)
-
Lu, ChanCent South Univ, Xiangya Med Coll, Sch Publ Hlth, Dept Occupat & Environm Hlth, Changsha, Peoples R China.
(författare)
-
Yu, WeiChongqing Univ, Minist Educ, Joint Int Res Lab Green Bldg & Built Environm, Chongqing, Peoples R China.
(författare)
-
Wang, TingtingShanghai Univ Med & Hlth Sci, Sch Nursing & Hlth Management, Shanghai, Peoples R China.
(författare)
-
Zheng, XiaohongSoutheast Univ, Sch Energy & Environm, Nanjing, Peoples R China.
(författare)
-
Zhang, LingWuhan Univ Sci & Technol, Med Coll, Sch Publ Hlth, Dept Environm Hyg & Occupat Med, Wuhan, Peoples R China.;Wuhan Univ Sci & Technol, Hubei Prov Key Lab Occupat Hazard Identificat & C, Wuhan, Peoples R China.
(författare)
-
Wuhan Univ Sci & Technol, Med Coll, Sch Publ Hlth, Dept Environm Hyg & Occupat Med, Wuhan, Peoples R China.;Wuhan Univ Sci & Technol, Hubei Prov Key Lab Occupat Hazard Identificat & C, Wuhan, Peoples R China.Wuhan Univ Sci & Technol, Hubei Prov Key Lab Occupat Hazard Identificat & C, Wuhan, Peoples R China.;Wuhan Univ Sci & Technol, Med Coll, Sch Publ Hlth, Dept Epidemiol & Biostat, Wuhan, Peoples R China.
(creator_code:org_t)
Sammanhörande titlar
-
Ingår i:JAMA Network Open: American Medical Association (AMA)5:102574-3805
Internetlänk
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Wu, Chuansha
-
Zhang, Yunquan
-
Wei, Jing
-
Zhao, Zhuohui
-
Norbäck, Dan
-
Zhang, Xin
-
visa fler...
-
Lu, Chan
-
Yu, Wei
-
Wang, Tingting
-
Zheng, Xiaohong
-
Zhang, Ling
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Lungmedicin och ...
- Artiklar i publikationen
-
JAMA Network Ope ...
- Av lärosätet
-
Uppsala universitet