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Prognostic accuracy...
Prognostic accuracy of head computed tomography for prediction of functional outcome after out-of-hospital cardiac arrest : Rationale and design of the prospective TTM2-CT-substudy
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- Lang, Margareta (författare)
- Lund University,Lunds universitet,Kliniska Vetenskaper, Helsingborg,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Clinical Sciences, Helsingborg,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Helsingborg Hospital
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- Leithner, Christoph (författare)
- Charite Univ Med Berlin, Dept Neurol & Expt Neurol, Berlin, Germany.,Charité - University Medicine Berlin
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- Scheel, Michael (författare)
- Charite Univ Med Berlin, Dept Neuroradiol, Berlin, Germany.,Charité - University Medicine Berlin
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- Kenda, Martin (författare)
- Charite Univ Med Berlin, Dept Neurol & Expt Neurol, Berlin, Germany.;Charite Univ Med Berlin, Berlin Inst Hlth, Berlin, Germany.,Charité - University Medicine Berlin,Berlin Institute of Health (BIH)
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- Cronberg, Tobias (författare)
- Lund University,Lunds universitet,Brain Injury After Cardiac Arrest,Forskargrupper vid Lunds universitet,Lund University Research Groups,Skåne University Hospital
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- During, Joachim (författare)
- Lund University,Lunds universitet,Anestesiologi och intensivvård,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Anesthesiology and Intensive Care,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital
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- Rylander, Christian (författare)
- Uppsala University,Uppsala universitet,Anestesiologi och intensivvård,Uppsala Univ, Sweden
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- Annborn, Martin (författare)
- Lund University,Lunds universitet,Kliniska Vetenskaper, Helsingborg,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Clinical Sciences, Helsingborg,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Helsingborg Hospital
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- Dankiewicz, Josef (författare)
- Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital
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- Deye, Nicolas (författare)
- Lariboisiere Hosp, Dept Med & Toxicol Intens Care Unit, Paris, France.,Lariboisière Hospital
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- Halliday, Thomas (författare)
- Linköping Univ Hosp, Dept Operat & Intens Care, Linköping, Sweden.,Region Östergötland, ANOPIVA US,Linköping University Hospital
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- Lascarrou, Jean-Baptiste (författare)
- Univ Hosp Ctr, Med Intens Reanimat, Nantes, France.,Nantes University Hospital
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- Matthew, Thomas (författare)
- Univ Hosp, Intens Care Unit, Bristol, Avon, England.;Univ Hosp, Intens Care Unit, Weston, England.,University Hospitals, England, Bristol and Weston
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- McGuigan, Peter (författare)
- Royal Victoria Hosp, Reg Intens Care Unit, Belfast, Antrim, North Ireland.,Royal Victoria Hospital, Belfast
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- Morgan, Matt (författare)
- Royal Perth Hosp, Dept Intens Care, Perth, WA, Australia.;Univ Hosp Wales, Dept Intens Care, Cardiff, Wales.;Curtin Univ, Sch Med, Perth, WA, Australia.,Royal Perth Hospital,University Hospital of Wales,Curtin University
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- Thomas, Matthew (författare)
- Univ Hosp, Bristol, Avon, England.;Univ Hosp, Weston, England.
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- Ullén, Susann (författare)
- Skane Univ Hosp, Clin Studies Sweden Forum South, Lund, Sweden.,Skåne University Hospital
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- Undén, Johan (författare)
- Lund University,Lunds universitet,Anestesiologi och intensivvård,Forskargrupper vid Lunds universitet,Anaesthesiology and Intensive Care Medicine,Lund University Research Groups,Halmstad County Hospital
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- Nielsen, Niklas (författare)
- Lund University,Lunds universitet,Centrum för hjärtstopp,Forskargrupper vid Lunds universitet,Center for cardiac arrest,Lund University Research Groups,Helsingborg Hospital
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- Moseby-Knappe, Marion (författare)
- Lund University,Lunds universitet,Brain Injury After Cardiac Arrest,Forskargrupper vid Lunds universitet,Lund University Research Groups,Skåne University Hospital
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(creator_code:org_t)
- Elsevier, 2022
- 2022
- Engelska.
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Ingår i: Resuscitation Plus. - : Elsevier. - 2666-5204. ; 12
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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http://dx.doi.org/10... (free)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- Background: Head computed tomography (CT) is a guideline recommended method to predict functional outcome after cardiac arrest (CA), but standardized criteria for evaluation are lacking. To date, no prospective trial has systematically validated methods for diagnosing hypoxic-ischaemic encephalopathy (HIE) on CT after CA. We present a protocol for validation of pre-specified radiological criteria for assessment of HIE on CT for neuroprognostication after CA.Methods/design: This is a prospective observational international multicentre substudy of the Targeted Hypothermia versus Targeted Normother-mia after out-of-hospital cardiac arrest (TTM2) trial. Patients still unconscious 48 hours post-arrest at 13 participating hospitals were routinely exam-ined with CT. Original images will be evaluated by examiners blinded to clinical data using a standardized protocol. Qualitative assessment will include evaluation of absence/presence of "severe HIE". Radiodensities will be quantified in pre-specified regions of interest for calculation of grey-white matter ratios (GWR) at the basal ganglia level. Functional outcome will be dichotomized into good (modified Rankin Scale 0-3) and poor (modified Rankin Scale 4-6) at six months post-arrest. Prognostic accuracies for good and poor outcome will be presented as sensitivities and speci-ficities with 95% confidence intervals (using pre-specified cut-offs for quantitative analysis), descriptive statistics (Area Under the Receiver Operating Characteristics Curve), inter-and intra-rater reliabilities according to STARD guidelines.Conclusions: The results from this prospective trial will validate a standardized approach to radiological evaluations of HIE on CT for prediction of functional outcome in comatose CA patients.The TTM2 trial and the TTM2 CT substudy are registered at ClinicalTrials.gov NCT02908308 and NCT03913065.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Anestesi och intensivvård (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Anesthesiology and Intensive Care (hsv//eng)
Nyckelord
- Neuroprognostication
- Computed tomography
- Hypoxic-ischaemic encephalopathy (HIE)
- Cardiac arrest
- Targeted temper-ature management
- Outcome
- GWR grey-white matter ratio
- Cardiac arrest
- Computed tomography
- GWR grey-white matter ratio
- Hypoxic-ischaemic encephalopathy (HIE)
- Neuroprognostication
- Outcome
- Targeted temperature management
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Lang, Margareta
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Leithner, Christ ...
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Scheel, Michael
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Kenda, Martin
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Cronberg, Tobias
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During, Joachim
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visa fler...
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Rylander, Christ ...
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Annborn, Martin
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Dankiewicz, Jose ...
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Deye, Nicolas
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Halliday, Thomas
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Lascarrou, Jean- ...
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Matthew, Thomas
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McGuigan, Peter
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Morgan, Matt
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Thomas, Matthew
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Ullén, Susann
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Undén, Johan
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Nielsen, Niklas
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Moseby-Knappe, M ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Anestesi och int ...
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Resuscitation Pl ...
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Uppsala universitet
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Linköpings universitet
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