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Enhancement of anti...
Enhancement of antiviral drug efficacy through multimodal mechanism of Au nanoparticles decorated ZnO tetrapods
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Suryawanshi, Rahul K. (författare)
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Patil, Chandrashekhar D. (författare)
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Koujah, Lulia (författare)
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visa fler...
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- Panda, Pritam Kumar, PhD Student, 1991- (författare)
- Uppsala universitet,Materialteori
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Singh, Sudhanshu Kumar (författare)
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Agelidis, Alex (författare)
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Volety, Ipsita (författare)
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Siebert, Leonard (författare)
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Adelung, Rainer (författare)
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- Ahuja, Rajeev, 1965- (författare)
- Uppsala universitet,Materialteori,Applied Materials Physics, Department of Materials Science and Engineering, Royal Institute of Technology (KTH)
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Mishra, Yogendra Kumar (författare)
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Shukla, Deepak (författare)
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visa färre...
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(creator_code:org_t)
- Engelska.
- Relaterad länk:
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https://urn.kb.se/re...
Abstract
Ämnesord
Stäng
- Nanoparticles have been well studied for controlling viral infections. However, very little knowledge exists on their potential use as an adjuvant for enhancing antiviral drug efficacy and reducing toxicity. Herein, we describe gold nanoparticle decorated zinc oxide tetrapods (ANZOT) that electrostatically neutralize viral infections. Given their negative charge distribution caused by engineered oxygen vacancies, ANZOT can prevent herpes simplex virus-1 and the novel human coronavirus, SARS-CoV-2 from infecting cells. More notably, when ANZOT was used as an adjuvant, several fold lower than normally used concentrations of a nucleoside analog, acyclovir or a preclinical antiviral compound, BX795, were enough to inhibit infection and eliminate drug toxicity. BX795 was found to exert its antiviral benefits through inhibition of cellular protein kinase C (α and ζ). Cumulatively our findings highlight an innovative use of ANZOT as a drug adjuvant for superior broad-spectrum effects against viral infections.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
Nyckelord
- Herpesvirus
- BX795
- Zinc Oxide Tetrapod
- gold nanoparticles
- antiviral
- virus neutralization
- Farmaceutisk vetenskap
- Pharmaceutical Science
Publikations- och innehållstyp
- vet (ämneskategori)
- ovr (ämneskategori)
- Av författaren/redakt...
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Suryawanshi, Rah ...
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Patil, Chandrash ...
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Koujah, Lulia
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Panda, Pritam Ku ...
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Singh, Sudhanshu ...
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Agelidis, Alex
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visa fler...
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Volety, Ipsita
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Siebert, Leonard
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Adelung, Rainer
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Ahuja, Rajeev, 1 ...
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Mishra, Yogendra ...
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Shukla, Deepak
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Farmaceutiska ve ...
- Av lärosätet
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Uppsala universitet