Sökning: onr:"swepub:oai:DiVA.org:uu-497304" > Immune signature of...
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000 | 05818naa a2200565 4500 | |
001 | oai:DiVA.org:uu-497304 | |
003 | SwePub | |
008 | 230228s2023 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4973042 URI |
024 | 7 | a https://doi.org/10.1007/s12020-022-03218-12 DOI |
040 | a (SwePub)uu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Ghosal, Sumanu Eunice Kennedy Shriver NICHHD, Sect Med Neuroendocrinol, NIH, Bethesda, MD 20892 USA.4 aut |
245 | 1 0 | a Immune signature of pheochromocytoma and paraganglioma in context of neuroendocrine neoplasms associated with prognosis |
264 | c 2022-11-12 | |
264 | 1 | b Springer Nature,c 2023 |
338 | a print2 rdacarrier | |
520 | a PurposeTo understand prognostic immune cell infiltration signatures in neuroendocrine neoplasms (NENs), particularly pheochromocytoma and paraganglioma (PCPG), we analyzed tumor transcriptomic data from The Cancer Genome Atlas (TCGA) and other published tumor transcriptomic data of NENs.MethodsWe used CIBERSORT to infer immune cell infiltrations from bulk tumor transcriptomic data from PCPGs, in comparison to gastroenteropancreatic neuroendocrine tumors (GEPNETs) and small cell lung carcinomas (SCLCs). PCPG immune signature was validated with NanoString immune panel in an independent cohort. Unsupervised clustering of the immune infiltration scores from CIBERSORT was used to find immune clusters. A prognostic immune score model for PCPGs and the other NENs were calculated as a linear combination of the estimated infiltration of activated CD8+/CD4+ T cells, activated NK cells, and M0 and M2 macrophages.ResultsIn PCPGs, we found five dominant immune clusters, associated with M2 macrophages, monocytes, activated NK cells, M0 macrophages and regulatory T cells, and CD8+/CD4+ T cells respectively. Non-metastatic tumors were associated with activated NK cells and metastatic tumors were associated with M0 macrophages and regulatory T cells. In GEPNETs and SCLCs, M0 macrophages and regulatory T cells were associated with unfavorable outcomes and features, such as metastasis and high-grade tumors. The prognostic immune score model for PCPGs and the NENs could predict non-aggressive and non-metastatic diseases. In PCPGs, the immune score was also an independent predictor of metastasis-free survival in a multivariate Cox regression analysis.ConclusionThe transcriptomic immune signature in PCPG correlates with clinical features like metastasis and prognosis. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
653 | a Immunologic signature | |
653 | a Pheochromocytoma | |
653 | a Paraganglioma | |
653 | a Metastasis | |
653 | a Biomarkers | |
700 | 1 | a Vanova, Katerina Hadravau Eunice Kennedy Shriver NICHHD, Sect Med Neuroendocrinol, NIH, Bethesda, MD 20892 USA.4 aut |
700 | 1 | a Uher, Ondreju Eunice Kennedy Shriver NICHHD, Sect Med Neuroendocrinol, NIH, Bethesda, MD 20892 USA.;Univ South Bohemia, Fac Sci, Dept Med Biol, Ceske Budejovice 37005, Czech Republic.4 aut |
700 | 1 | a Das, Shaoliu NCI, Radiat Oncol Branch, Ctr Canc Res, NIH, Bethesda, MD 20892 USA.4 aut |
700 | 1 | a Patel, Mayanku Eunice Kennedy Shriver NICHHD, Sect Med Neuroendocrinol, NIH, Bethesda, MD 20892 USA.4 aut |
700 | 1 | a Meuter, Leahu Eunice Kennedy Shriver NICHHD, Sect Med Neuroendocrinol, NIH, Bethesda, MD 20892 USA.4 aut |
700 | 1 | a Huynh, Thanh-Trucu Eunice Kennedy Shriver NICHHD, Sect Med Neuroendocrinol, NIH, Bethesda, MD 20892 USA.4 aut |
700 | 1 | a Jha, Abhisheku Eunice Kennedy Shriver NICHHD, Sect Med Neuroendocrinol, NIH, Bethesda, MD 20892 USA.4 aut |
700 | 1 | a Talvacchio, Sarau Eunice Kennedy Shriver NICHHD, Sect Med Neuroendocrinol, NIH, Bethesda, MD 20892 USA.4 aut |
700 | 1 | a Knue, Marianneu Eunice Kennedy Shriver NICHHD, Sect Med Neuroendocrinol, NIH, Bethesda, MD 20892 USA.4 aut |
700 | 1 | a Prodanov, Tamarau Eunice Kennedy Shriver NICHHD, Sect Med Neuroendocrinol, NIH, Bethesda, MD 20892 USA.4 aut |
700 | 1 | a Zeiger, Martha A.u NCI, Off Surg Scientists Programs, Ctr Canc Res, NIH, Bethesda, MD 20892 USA.4 aut |
700 | 1 | a Nilubol, Narisu NCI, Surg Oncol Program, Ctr Canc Res, NIH, Bethesda, MD 20892 USA.4 aut |
700 | 1 | a Taieb, Davidu Aix Marseille Univ, La Timone Univ Hosp, Dept Nucl Med, Marseille, France.;Aix Marseille Univ, European Ctr Res Med Imaging, Marseille, France.4 aut |
700 | 1 | a Crona, Joakimu Uppsala universitet,Endokrin tumörbiologi,Eunice Kennedy Shriver NICHHD, Sect Med Neuroendocrinol, NIH, Bethesda, MD 20892 USA4 aut0 (Swepub:uu)joacr310 |
700 | 1 | a Shankavaram, Uma T.u NCI, Radiat Oncol Branch, Ctr Canc Res, NIH, Bethesda, MD 20892 USA.4 aut |
700 | 1 | a Pacak, Karelu Eunice Kennedy Shriver NICHHD, Sect Med Neuroendocrinol, NIH, Bethesda, MD 20892 USA.4 aut |
710 | 2 | a Eunice Kennedy Shriver NICHHD, Sect Med Neuroendocrinol, NIH, Bethesda, MD 20892 USA.b Eunice Kennedy Shriver NICHHD, Sect Med Neuroendocrinol, NIH, Bethesda, MD 20892 USA.;Univ South Bohemia, Fac Sci, Dept Med Biol, Ceske Budejovice 37005, Czech Republic.4 org |
773 | 0 | t Endocrined : Springer Natureg 79:1, s. 171-179q 79:1<171-179x 1355-008Xx 1559-0100 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-497304 |
856 | 4 8 | u https://doi.org/10.1007/s12020-022-03218-1 |
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