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Development of sens...
Development of sensitization to peanut and storage proteins and relation to markers of airway and systemic inflammation : A 24-year follow-up
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- Tedner, Sandra G. (författare)
- Karolinska Institutet
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- Klevebro, Susanna (författare)
- Karolinska Institutet
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- Bergström, Anna (författare)
- Karolinska Institutet
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- Kull, Inger (författare)
- Karolinska Institutet
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- Andersson, Niklas (författare)
- Karolinska Institutet
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- Borres, Magnus P., 1956- (författare)
- Uppsala universitet,Pediatrisk inflammations- och metabolismforskning samt barnhälsa,Thermo Fisher Scientific, Uppsala, Sweden
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- Ballardini, Natalia (författare)
- Karolinska Institutet
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- Westman, Marit (författare)
- Karolinska Institutet
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- Konradsen, Jon R. (författare)
- Karolinska Institutet
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- van Hage, Marianne (författare)
- Karolinska Institutet
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- Nilsson, Caroline (författare)
- Karolinska Institutet
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- Melén, Erik (författare)
- Karolinska Institutet
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- Asarnoj, Anna (författare)
- Karolinska Institutet
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(creator_code:org_t)
- 2022-11-14
- 2023
- Engelska.
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Ingår i: Allergy. European Journal of Allergy and Clinical Immunology. - : John Wiley & Sons. - 0105-4538 .- 1398-9995. ; 78:2, s. 488-499
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Abstract
Ämnesord
Stäng
- BackgroundLong-time data of peanut allergy over time is sparse. We aimed to study the longitudinal development of sensitization to peanut extract and storage protein allergen molecules and associations with asthma status, airway and systemic inflammation markers.MethodsThe Swedish birth cohort BAMSE followed 4089 participants with questionnaires, clinical investigations and blood sampling between 0 and 24 years. Information on (i) background factors at 2 months, (ii) peanut allergy symptoms and IgE data (ImmunoCAP) at 4, 8, 16, and 24 years, and (iii) IgE to storage proteins, lung function data including exhaled nitric oxide (FENO) as well as systemic inflammatory markers at 24 years of age were collected.ResultsThe prevalence of peanut extract sensitization, defined as IgE ≥ 0.35 kUA/L, was 5.4%, 8.0%, 7.5%, and 6.2% at 4, 8, 16, and 24 years of age, respectively. Between 8 and 24 years of age, (33/1565) participants developed IgE-ab to peanut extract (median 1,4, range 0.7–2.6 kUA/L), and among those 85% were also sensitized to birch. Only six individuals developed sensitization to Ara h 2 (≥0.1 kUA/L) between 8 and 24 years of age, of whom three had an IgE-ab level between 0.1–0.12 kUA/L. Storage protein sensitization was associated with elevated FENO, blood eosinophils and type 2 inflammation-related systemic proteins.ConclusionSensitization to peanut extract after 4 years of age is mainly induced by birch cross-sensitization and IgE to Ara h 2 rarely emerges after eight years of age. Storage protein sensitization is associated with respiratory and systemic inflammation.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Nyckelord
- birth cohort
- FENO
- molecular allergology
- OLINK
- peanut allergy
- sensitization
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Tedner, Sandra G ...
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Klevebro, Susann ...
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Bergström, Anna
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Kull, Inger
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Andersson, Nikla ...
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Borres, Magnus P ...
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visa fler...
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Ballardini, Nata ...
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Westman, Marit
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Konradsen, Jon R ...
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van Hage, Marian ...
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Nilsson, Carolin ...
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Melén, Erik
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Asarnoj, Anna
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visa färre...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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Allergy. Europea ...
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Uppsala universitet
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Karolinska Institutet