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Early disc degenera...
Early disc degeneration in radiotherapy-treated childhood brain tumor survivors
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- Grahn, Petra (författare)
- Univ Helsinki, Dept Pediat Orthoped & Traumatol, Stenbackinkatu 9, PL 281, Helsinki 00029, Finland.;Helsinki Univ Hosp, Stenbackinkatu 9, PL 281, Helsinki 00029, Finland.
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- Remes, Tiina (författare)
- Oulu Univ Hosp, Dept Pediat & Adolescent Med, Helsinki, Finland.;Univ Oulu, Res Unit Clin Med, Helsinki, Finland.;Univ Helsinki, Helsinki Univ Hosp, New Childrens Hosp, Dept Child Neurol, Helsinki, Finland.
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- Kivisaari, Reetta (författare)
- Univ Helsinki, Dept Radiol, Helsinki, Finland.;Helsinki Univ Hosp, Helsinki, Finland.
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- Suo-Palosaari, Maria. H. H. (författare)
- Oulu Univ Hosp, Dept Diagnost Radiol, Oulu, Finland.;Univ Oulu, Med Res Ctr Oulu, Res Unit Med Imaging Phys & Technol, Oulu, Finland. Univ Eastern Finland, Kuopio Pediat Res Unit, Kuopio, Finland.
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- Arikoski, Pekka. M. M. (författare)
- Kuopio Univ Hosp, Kuopio, Finland.
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- Koskenkorva, Paivi K. T. (författare)
- Univ Eastern Finland, Dept Clin Radiol, Kuopio, Finland. Turku Univ, Turku Univ Hosp, Dept Pediat & Adolescent Med, Turku, Finland.
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Lahteenmaki, Paivi M. (författare)
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- Lonnqvist, Tuula R. I. (författare)
- Univ Helsinki, Helsinki Univ Hosp, New Childrens Hosp, Dept Child Neurol, Helsinki, Finland.
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- Ojaniemi, Marja. K. K. (författare)
- Univ Oulu, Res Unit Clin Med, Helsinki, Finland.
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- Sirkia, Kirsti H. (författare)
- Helsinki Univ Hosp, Helsinki, Finland.;Univ Helsinki, Dept Pediat & Adolescence, Helsinki, Finland.
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- Sutela, Anna. K. K. (författare)
- Univ Eastern Finland, Dept Clin Radiol, Kuopio, Finland. Turku Univ, Turku Univ Hosp, Dept Pediat & Adolescent Med, Turku, Finland.
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- Toiviainen-Salo, Sanna-Maria (författare)
- Univ Helsinki, Dept Radiol, Helsinki, Finland.;Helsinki Univ Hosp, Helsinki, Finland.
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- Rantala, Heikki M. J. (författare)
- Oulu Univ Hosp, Dept Pediat & Adolescent Med, Helsinki, Finland.;Univ Oulu, Res Unit Clin Med, Helsinki, Finland.
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- Harila-Saari, Arja H. (författare)
- Uppsala universitet,Barnonkologisk och neurologisk forskning
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- Niinimaki, Jaakko (författare)
- Univ Oulu, Med Res Ctr Oulu, Res Unit Med Imaging Phys & Technol, Oulu, Finland. Univ Eastern Finland, Kuopio Pediat Res Unit, Kuopio, Finland.
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- Karppinen, Jaro (författare)
- Oulu Univ Hosp, Oulu, Finland. Finnish Inst Occupat Hlth, Oulu, Finland. Rehabil Serv South Karel Social & Hlth Care Dist, Lappeenranta, Finland.
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- Ahonen, Matti (författare)
- Univ Helsinki, Dept Pediat Orthoped & Traumatol, Stenbackinkatu 9, PL 281, Helsinki 00029, Finland.;Helsinki Univ Hosp, Stenbackinkatu 9, PL 281, Helsinki 00029, Finland.
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Univ Helsinki, Dept Pediat Orthoped & Traumatol, Stenbackinkatu 9, PL 281, Helsinki 00029, Finland;Helsinki Univ Hosp, Stenbackinkatu 9, PL 281, Helsinki 00029, Finland. Oulu Univ Hosp, Dept Pediat & Adolescent Med, Helsinki, Finland.;Univ Oulu, Res Unit Clin Med, Helsinki, Finland.;Univ Helsinki, Helsinki Univ Hosp, New Childrens Hosp, Dept Child Neurol, Helsinki, Finland. (creator_code:org_t)
- BioMed Central (BMC), 2023
- 2023
- Engelska.
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Ingår i: BMC Musculoskeletal Disorders. - : BioMed Central (BMC). - 1471-2474. ; 24:1
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- BackgroundChildhood brain tumor (BT) survivors have an increased risk of treatment-related late effects, which can reduce health-related quality of life and increase morbidity. This study aimed to investigate lumbar disc degeneration in magnetic resonance imaging (MRI) in adult survivors of radiotherapy-treated childhood BT compared to age and sex-matched population controls.MethodsIn this cross-sectional comparative study, 127 survivors were identified from hospital registries. After a mean follow-up of 20.7 years (range 5-33.1), 67 survivors (mean age 28.4, range 16.2-43.5) were investigated with MRI and compared to 75 sex-matched population-based controls. Evaluated MRI phenotypes included Pfirrmann grading, , intervertebral disc protrusions, extrusions, and high-intensity-zone-lesions (HIZ). Groups were also compared for known risk factors of lumbar intervertebral disc (IVD) degeneration.ResultsChildhood BT survivors had higher Pfirrmann grades than controls at all lumbar levels (all p < 0.001). Lumbar disc protrusions at L4-5 (p = 0.02) and extrusions at L3-4 (p = 0.04), L4-5 (p = 0.004), and L5-S1 (p = 0.01) were significantly more common in the BT group compared to the control. The survivor cohort also had significantly more HIZ-lesons than the controls (n=13 and n=1, p=0.003). Age at diagnosis was associated with lower degree of IVD degeneration (p < 0.01). Blood pressure correlated with IVD degeneration (P < 0.05).ConclusionsSigns of early disc degeneration related to tumor treatment can be seen in the IVDs of survivors. Disc degeneration was more severe in children treated in adolescence.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Ortopedi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Orthopaedics (hsv//eng)
Nyckelord
- Childhood brain tumor survivor
- Radiotherapy
- Disc degeneration
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Grahn, Petra
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Remes, Tiina
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Kivisaari, Reett ...
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Suo-Palosaari, M ...
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Arikoski, Pekka. ...
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Koskenkorva, Pai ...
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visa fler...
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Lahteenmaki, Pai ...
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Lonnqvist, Tuula ...
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Ojaniemi, Marja. ...
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Sirkia, Kirsti H ...
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Sutela, Anna. K. ...
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Toiviainen-Salo, ...
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Rantala, Heikki ...
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Harila-Saari, Ar ...
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Niinimaki, Jaakk ...
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Karppinen, Jaro
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Ahonen, Matti
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Ortopedi
- Artiklar i publikationen
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BMC Musculoskele ...
- Av lärosätet
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Uppsala universitet