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Sökning: onr:"swepub:oai:DiVA.org:uu-510723" > The Association Bet...

  • D'Oria, MarioTrieste Univ Hosp ASUIGI, Cardiovasc Dept, Div Vasc & Endovasc Surg, Trieste, Italy.;Univ Hosp Trieste ASUGI, Cardiovasc Dept, Div Vasc & Endovasc Surg, Str Fiume 447, Trieste, TS, Italy. (författare)

The Association Between Body Mass Index and Death Following Elective Endovascular and Open Repair of Abdominal Aortic Aneurysms in the Vascular Quality Initiative

  • Artikel/kapitelEngelska2023

Förlag, utgivningsår, omfång ...

  • Elsevier BV,2023
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-510723
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-510723URI
  • https://doi.org/10.1016/j.ejvs.2023.01.047DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

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Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Objective: The effect of body mass index (BMI) on post-operative outcomes after abdominal aortic aneurysm (AAA) repair remains poorly defined. The association between BMI and death following elective endovascular aneurysm repair (EVAR) and open aneurysm repair (OAR) of AAA in a large national quality registry is investigated.Methods: All elective AAA repairs within the Society for Vascular Surgery Vascular Quality Initiative (VQI; 2010 to September 2021) were reviewed (EVAR, n = 53 426; OAR, n = 9 479). All analyses were conducted separately for EVAR and OAR patients. The primary end points were 30 day mortality and five year survival rates. Study cohorts were divided into World Health Organisation BMI categories (C1 < 18.5, C2 18.5 <= BMI < 25, C3 25 <= BMI < 30, C4, 30 <= BMI < 35, C5 35 <= BMI < 40, C6 >= 40). BMI was examined as both a categorical and continuous variable. Logistic and Cox proportional hazards regression were used for risk adjustment.Results: Among EVAR patients, BMI distribution was C1, 1 216 (2%); C2, 14 687 (28%); C3, 20 516 (38%); C4, 11 352 (21%); C5, 3 947 (7%); C6, 1 708 (3%). Class 1, 2, and 6 BMI patients experienced an increased 30 daymortality rate (C1 2.6%; C2 1.3%; C6 1.4% vs. C3 - 5 0.7%; p < .001) and C1 and C2 had correspondingly inferior long termsurvival (five years: C1 69 +/- 3%; C2 79 +/- 1% vs. C3 - 6 86 - 88 +/- 2%; log rank p <.001). These survival disparities persisted after risk adjustment formultiple confounders. In the OAR cohort, BMI distribution was C1, 280 (3%); C2, 2 862 (30%); C3, 3 587 (38%); C4, 1 940 (21%); C5, 581 (6%); C6, 229 (2%). Crude 30 day mortality rates were increased for both the lowest and highest BMI patients (C1 12%, C6 7% vs. C2 - 5 3 - 4%; p < .001); these differences also persisted in long term survival (five years: C1 71 +/- 6%, C6 82 +/- 6% vs. C2 - 6 85 - 88 +/- 3%; log rank p <.001). In risk adjusted analysis, both low and high BMI OAR patients had an increased 30 day and long term mortality rate.Conclusion: Within the VQI, both the extreme low (< 18.5) and high (>= 40) BMI groups experienced an increased 30 day mortality rate after both elective EVAR and OAR. By comparison, while the lowest BMI cohort was significantly associated with decreased long term survival after both procedures, the highest BMI group only experienced reduced long termsurvival after OAR. Based upon this large real world registry analysis of elective AAA repairs, differential metabolic signatures exist within extreme BMI categories, which may inform peri-operative risk stratification and clinical decision making.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Scali, SalvatoreUniv Florida, Div Vasc Surg & Endovasc Therapy, Gainesville, FL USA. (författare)
  • Neal, DanUniv Florida, Div Vasc Surg & Endovasc Therapy, Gainesville, FL USA. (författare)
  • DeMartino, RandallMayo Clin, Gonda Vasc Ctr, Div Vasc & Endovasc Surg, Rochester, MN USA. (författare)
  • Mani, Kevin,1975-Uppsala universitet,Kärlkirurgi(Swepub:uu)kevma940 (författare)
  • Budtz-Lilly, JacobAarhus Univ Hosp, Dept Cardiovasc Surg, Div Vasc Surg, Aarhus, Denmark. (författare)
  • Lepidi, SandroTrieste Univ Hosp ASUIGI, Cardiovasc Dept, Div Vasc & Endovasc Surg, Trieste, Italy. (författare)
  • Stone, David H.Dartmouth Hitchcock Med Ctr, Sect Vasc Surg, Lebanon, NH USA. (författare)
  • Trieste Univ Hosp ASUIGI, Cardiovasc Dept, Div Vasc & Endovasc Surg, Trieste, Italy.;Univ Hosp Trieste ASUGI, Cardiovasc Dept, Div Vasc & Endovasc Surg, Str Fiume 447, Trieste, TS, Italy.Univ Florida, Div Vasc Surg & Endovasc Therapy, Gainesville, FL USA. (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:European Journal of Vascular and Endovascular Surgery: Elsevier BV66:1, s. 27-361078-58841532-2165

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