Global estimates and determinants of antituberculosis drug pharmacokinetics in children and adolescents: a systematic review and individual patient data meta-analysis

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Fältnamn	Indikatorer	Metadata
000		12498naa a2201069 4500
001		oai:DiVA.org:uu-510813
003		SwePub
008		230904s2023 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5108132 URI
024	7	a https://doi.org/10.1183/13993003.01596-20222 DOI
040		a (SwePub)uu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a for2 swepub-publicationtype
100	1	a Gafar, Fajriu Univ Groningen, Groningen Res Inst Pharm, Unit PharmacoTherapy Epidemiol & Econ, Groningen, Netherlands.4 aut
245	1 0	a Global estimates and determinants of antituberculosis drug pharmacokinetics in children and adolescents :b a systematic review and individual patient data meta-analysis
264		c 2022-11-03
264	1	b European Respiratory Society,c 2023
338		a electronic2 rdacarrier
520		a Background Suboptimal exposure to antituberculosis (anti-TB) drugs has been associated with unfavourable treatment outcomes. We aimed to investigate estimates and determinants of first-line anti-TB drug pharmacokinetics in children and adolescents at a global level.Methods We systematically searched MEDLINE, Embase and Web of Science (1990–2021) for pharmacokinetic studies of first-line anti-TB drugs in children and adolescents. Individual patient data were obtained from authors of eligible studies. Summary estimates of total/extrapolated area under the plasma concentration–time curve from 0 to 24 h post-dose (AUC0–24) and peak plasma concentration (Cmax) were assessed with random-effects models, normalised with current World Health Organization-recommended paediatric doses. Determinants of AUC0–24 and Cmax were assessed with linear mixed-effects models.Results Of 55 eligible studies, individual patient data were available for 39 (71%), including 1628 participants from 12 countries. Geometric means of steady-state AUC0–24 were summarised for isoniazid (18.7 (95% CI 15.5–22.6) h·mg·L−1), rifampicin (34.4 (95% CI 29.4–40.3) h·mg·L−1), pyrazinamide (375.0 (95% CI 339.9–413.7) h·mg·L−1) and ethambutol (8.0 (95% CI 6.4–10.0) h·mg·L−1). Our multivariate models indicated that younger age (especially <2 years) and HIV-positive status were associated with lower AUC0–24 for all first-line anti-TB drugs, while severe malnutrition was associated with lower AUC0–24 for isoniazid and pyrazinamide. N-acetyltransferase 2 rapid acetylators had lower isoniazid AUC0–24 and slow acetylators had higher isoniazid AUC0–24 than intermediate acetylators. Determinants of Cmax were generally similar to those for AUC0–24.Conclusions This study provides the most comprehensive estimates of plasma exposures to first-line anti-TB drugs in children and adolescents. Key determinants of drug exposures were identified. These may be relevant for population-specific dose adjustment or individualised therapeutic drug monitoring.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Farmaceutiska vetenskaper0 (SwePub)301012 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Pharmaceutical Sciences0 (SwePub)301012 hsv//eng
700	1	a Wasmann, Roeland E.u Univ Cape Town, Div Clin Pharmacol, Dept Med, Cape Town, South Africa.4 aut
700	1	a McIlleron, Helen M.u Univ Cape Town, Div Clin Pharmacol, Dept Med, Cape Town, South Africa.;Univ Cape Town, Inst Infect Dis & Mol Med, Wellcome Ctr Infect Dis Res Africa CIDRI Africa, Cape Town, South Africa.4 aut
700	1	a Aarnoutse, Rob E.u Radboud Univ Nijmegen, Radboud Inst Hlth Sci, Dept Pharm, Med Ctr, Nijmegen, Netherlands.4 aut
700	1	a Schaaf, H. Simonu Stellenbosch Univ, Dept Paediat & Child Hlth, Desmond Tutu TB Ctr, Fac Med & Hlth Sci, Tygerberg, South Africa.4 aut
700	1	a Marais, Ben J.u Childrens Hosp Westmead, Sydney, NSW, Australia.;Univ Sydney, Sydney Inst Infect Dis, Sydney, NSW, Australia.4 aut
700	1	a Agarwal, Diptiu Ram Manohar Lohia Inst Med Sci, Dept Paediat, Lucknow, Uttar Pradesh, India.4 aut
700	1	a Antwi, Sampsonu Komfo Anokye Teaching Hosp, Dept Child Hlth, Kumasi, Ghana.;Kwame Nkrumah Univ Sci & Technol, Sch Med Sci, Dept Child Hlth, Kumasi, Ghana.4 aut
700	1	a Bang, Nguyen D.u Pham Ngoc Thach Hosp, Ho Chi Minh City, Vietnam.4 aut
700	1	a Bekker, Adrieu Stellenbosch Univ, Dept Paediat & Child Hlth, Desmond Tutu TB Ctr, Fac Med & Hlth Sci, Tygerberg, South Africa.4 aut
700	1	a Bell, David J.u NHS Greater Glasgow & Clyde, Infect Dis Unit, Glasgow, Lanark, Scotland.4 aut
700	1	a Chabala, Chishalau Univ Cape Town, Div Clin Pharmacol, Dept Med, Cape Town, South Africa.;Univ Zambia, Sch Med, Dept Paediat, Lusaka, Zambia.;Childrens Hosp, Univ Teaching Hosp, Lusaka, Zambia.4 aut
700	1	a Choo, Louiseu UCL, Med Res Council, Clin Trials Unit, London, England.4 aut
700	1	a Davies, Geraint R.u Malawi Liverpool Wellcome Clin Res Programme, Clin Dept, Blantyre, Malawi.;Univ Liverpool, Inst Infect Vet & Ecol Sci, Liverpool, Merseyside, England.4 aut
700	1	a Day, Jeremy N.u Univ Oxford, Clin Res Unit, Ho Chi Minh City, Vietnam.;Univ Oxford, Nuffield Dept Med, Ctr Trop Med & Global Hlth, Oxford, England.4 aut
700	1	a Dayal, Rajeshwaru Sarojini Naidu Med Coll, Dept Pediat, Agra, Uttar Pradesh, India.4 aut
700	1	a Denti, Paolou Univ Cape Town, Div Clin Pharmacol, Dept Med, Cape Town, South Africa.4 aut
700	1	a Donald, Peter R.u Stellenbosch Univ, Dept Paediat & Child Hlth, Desmond Tutu TB Ctr, Fac Med & Hlth Sci, Tygerberg, South Africa.4 aut
700	1	a Engidawork, Ephremu Addis Ababa Univ, Sch Pharm, Dept Pharmacol & Clin Pharm, Coll Hlth Sci, Addis Ababa, Ethiopia.4 aut
700	1	a Garcia-Prats, Anthony J.u Stellenbosch Univ, Dept Paediat & Child Hlth, Desmond Tutu TB Ctr, Fac Med & Hlth Sci, Tygerberg, South Africa.;Univ Wisconsin, Sch Med & Publ Hlth, Dept Pediat, Madison, WI USA.4 aut
700	1	a Gibb, Dianau UCL, Med Res Council, Clin Trials Unit, London, England.4 aut
700	1	a Graham, Stephen M.u Univ Melbourne, Dept Pediat, Melbourne, Vic, Australia.;Royal Childrens Hosp, Murdoch Childrens Res Inst, Melbourne, Vic, Australia.;Int Union TB & Lung Dis, Paris, France.4 aut
700	1	a Hesseling, Anneke C.u Stellenbosch Univ, Dept Paediat & Child Hlth, Desmond Tutu TB Ctr, Fac Med & Hlth Sci, Tygerberg, South Africa.4 aut
700	1	a Heysell, Scott K.u Univ Virginia, Div Infect Dis & Int Hlth, Charlottesville, VA USA.4 aut
700	1	a Idris, Misgana I.u Univ Alabama Birmingham, Dept Biol, Birmingham, AL 35294 USA.4 aut
700	1	a Kabra, Sushil K.u All India Inst Med Sci, Dept Pediat, New Delhi, India.4 aut
700	1	a Kinikar, Aartiu Johns Hopkins Univ, Byramjee Jeejeebhoy Govt Med Coll, Clinical Res Site, Pune, Maharashtra, India.4 aut
700	1	a Kumar, Agibothu K. Hemanthu Indian Council Med Res, Natl Inst Res TB, Chennai, Tamil Nadu, India.4 aut
700	1	a Kwara, Awewurau Univ Florida, Emerging Pathogens Inst, Coll Med, Gainesville, FL USA.4 aut
700	1	a Lodha, Rakeshu All India Inst Med Sci, Dept Pediat, New Delhi, India.4 aut
700	1	a Magis-Escurra, Cecileu Radboud Univ Nijmegen, Med Ctr, TB Expert Ctr, Nijmegen, Netherlands.4 aut
700	1	a Martinez, Nilzau Inst Nacl Enfermedades Resp & Ambiente, Asuncion, Paraguay.4 aut
700	1	a Mathew, Binu S.u Christian Med Coll & Hosp, Dept Pharmacol & Clin Pharmacol, Vellore, Tamil Nadu, India.4 aut
700	1	a Mave, Vidyau Johns Hopkins Univ, Byramjee Jeejeebhoy Govt Med Coll, Clinical Res Site, Pune, Maharashtra, India.;Johns Hopkins Univ, Dept Med & Infect Dis, Baltimore, MD USA.4 aut
700	1	a Mduma, Estomihu Haydom Lutheran Hosp, Ctr Global Hlth Res, Haydom, Tanzania.4 aut
700	1	a Mlotha-Mitole, Rachelu Queen Elizabeth Cent Hosp, Dept Paediat, Blantyre, Malawi.4 aut
700	1	a Mpagama, Stellah G.u Kibongoto Infect Dis Hosp, Sanya Juu, Tanzania.4 aut
700	1	a Mukherjee, Aparnau All India Inst Med Sci, Dept Pediat, New Delhi, India.4 aut
700	1	a Nataprawira, Heda M.u Univ Padjadjaran, Hasan Sadikin Hosp, Div Paediat Respirol, Dept Child Hlth,Fac Med, Bandung, Indonesia.4 aut
700	1	a Peloquin, Charles A.u Univ Florida, Coll Pharm, Gainesville, FL USA.4 aut
700	1	a Pouplin, Thomasu Mahidol Univ, Fac Trop Med, Mahidol Oxford Trop Med Res Unit, Bangkok, Thailand.4 aut
700	1	a Ramachandran, Geethau Indian Council Med Res, Natl Inst Res TB, Chennai, Tamil Nadu, India.4 aut
700	1	a Ranjalkar, Jayau Christian Med Coll & Hosp, Dept Pharmacol & Clin Pharmacol, Vellore, Tamil Nadu, India.4 aut
700	1	a Roy, Vandanau Maulana Azad Med Coll, Dept Pharmacol, New Delhi, India.4 aut
700	1	a Ruslami, Rovinau Univ Padjadjaran, Div Pharmacol & Therapy, Dept Biomed Sci, Fac Med, Bandung, Indonesia.4 aut
700	1	a Shah, Irau Bai Jerbai Wadia Hosp Children, Dept Pediat Infect Dis, Pediat TB Clin, Mumbai, Maharashtra, India.4 aut
700	1	a Singh, Yatishu Sarojini Naidu Med Coll, Dept Pediat, Agra, Uttar Pradesh, India.4 aut
700	1	a Sturkenboom, Marieke G. G.u Univ Groningen, Univ Med Ctr Groningen, Dept Clin Pharm & Pharmacol, Groningen, Netherlands.4 aut
700	1	a Svensson, Elin M.,d 1985-u Uppsala universitet,Institutionen för farmaci,Radboud Univ Nijmegen, Radboud Inst Hlth Sci, Dept Pharm, Med Ctr, Nijmegen, Netherlands4 aut0 (Swepub:uu)elisv718
700	1	a Swaminathan, Soumyau Indian Council Med Res, Natl Inst Res TB, Chennai, Tamil Nadu, India.;World Hlth Org, Publ Hlth Div, Geneva, Switzerland.4 aut
700	1	a Thatte, Urmilau Seth Gordhandas Sunderdas Med Coll & King Edward, Dept Clin Pharmacol, Mumbai, Maharashtra, India.4 aut
700	1	a Thee, Stephanieu Charite Univ Med Berlin, Berlin, Germany.;Free Univ Berlin, Berlin, Germany.;Humboldt Univ, Dept Pediat Resp Med Immunol & Crit Care Med, Berlin, Germany.4 aut
700	1	a Thomas, Tania A.u Univ Virginia, Div Infect Dis & Int Hlth, Charlottesville, VA USA.4 aut
700	1	a Tikiso, Tjokoselau Univ Cape Town, Div Clin Pharmacol, Dept Med, Cape Town, South Africa.4 aut
700	1	a Touw, Daan J.u Univ Groningen, Univ Med Ctr Groningen, Dept Clin Pharm & Pharmacol, Groningen, Netherlands.4 aut
700	1	a Turkova, Annau UCL, Med Res Council, Clin Trials Unit, London, England.4 aut
700	1	a Velpandian, Thirumurthyu All India Inst Med Sci, Dr RP Ctr, Ocular Pharmacol & Pharm Div, New Delhi, India.4 aut
700	1	a Verhagen, Lilly M.u Radboud Univ Nijmegen, Med Ctr, Radboud Ctr Infect Dis, Lab Med Immunol,Sect Pediat Infect Dis, Nijmegen, Netherlands.;Radboud Univ Nijmegen, Med Ctr, Amalia Childrens Hosp, Dept Paediat Infect Dis & Immunol, Nijmegen, Netherlands.;Stellenbosch Univ, Family Ctr Res, UBUNTU, Dept Paediat & Child Hlth, Cape Town, South Africa.4 aut
700	1	a Winckler, Jana L.u Stellenbosch Univ, Dept Paediat & Child Hlth, Desmond Tutu TB Ctr, Fac Med & Hlth Sci, Tygerberg, South Africa.4 aut
700	1	a Yang, Hongmeiu Univ Rochester, Sch Med & Dent, Dept Biostat & Computat Biol, Rochester, NY USA.4 aut
700	1	a Yunivita, Vyckeu Univ Padjadjaran, Div Pharmacol & Therapy, Dept Biomed Sci, Fac Med, Bandung, Indonesia.4 aut
700	1	a Taxis, Katjau Univ Groningen, Groningen Res Inst Pharm, Unit PharmacoTherapy Epidemiol & Econ, Groningen, Netherlands.4 aut
700	1	a Stevens, Jasperu Univ Groningen, Univ Med Ctr Groningen, Dept Clin Pharm & Pharmacol, Groningen, Netherlands.4 aut
700	1	a Alffenaar, Jan-Willem C.u Univ Sydney, Sydney Inst Infect Dis, Sydney, NSW, Australia.;Univ Sydney, Sch Pharm, Fac Med & Hlth, Sydney, NSW, Australia.;Westmead Hosp, Sydney, NSW, Australia.4 aut
710	2	a Univ Groningen, Groningen Res Inst Pharm, Unit PharmacoTherapy Epidemiol & Econ, Groningen, Netherlands.b Univ Cape Town, Div Clin Pharmacol, Dept Med, Cape Town, South Africa.4 org
773	0	t European Respiratory Journald : European Respiratory Societyg 61:3q 61:3x 0903-1936x 1399-3003
856	4	u https://doi.org/10.1183/13993003.01596-2022y Fulltext
856	4	u https://uu.diva-portal.org/smash/get/diva2:1794081/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-510813
856	4 8	u https://doi.org/10.1183/13993003.01596-2022

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Av författaren/redakt...: Gafar, Fajri; Wasmann, Roeland ...; McIlleron, Helen ...; Aarnoutse, Rob E ...; Schaaf, H. Simon; Marais, Ben J.; visa fler...; Agarwal, Dipti; Antwi, Sampson; Bang, Nguyen D.; Bekker, Adrie; Bell, David J.; Chabala, Chishal ...; Choo, Louise; Davies, Geraint ...; Day, Jeremy N.; Dayal, Rajeshwar; Denti, Paolo; Donald, Peter R.; Engidawork, Ephr ...; Garcia-Prats, An ...; Gibb, Diana; Graham, Stephen ...; Hesseling, Annek ...; Heysell, Scott K ...; Idris, Misgana I ...; Kabra, Sushil K.; Kinikar, Aarti; Kumar, Agibothu ...; Kwara, Awewura; Lodha, Rakesh; Magis-Escurra, C ...; Martinez, Nilza; Mathew, Binu S.; Mave, Vidya; Mduma, Estomih; Mlotha-Mitole, R ...; Mpagama, Stellah ...; Mukherjee, Aparn ...; Nataprawira, Hed ...; Peloquin, Charle ...; Pouplin, Thomas; Ramachandran, Ge ...; Ranjalkar, Jaya; Roy, Vandana; Ruslami, Rovina; Shah, Ira; Singh, Yatish; Sturkenboom, Mar ...; Svensson, Elin M ...; Swaminathan, Sou ...; Thatte, Urmila; Thee, Stephanie; Thomas, Tania A.; Tikiso, Tjokosel ...; Touw, Daan J.; Turkova, Anna; Velpandian, Thir ...; Verhagen, Lilly ...; Winckler, Jana L ...; Yang, Hongmei; Yunivita, Vycke; Taxis, Katja; Stevens, Jasper; Alffenaar, Jan-W ...; visa färre...

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