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Multimodal classifi...
Multimodal classification of molecular subtypes in pediatric acute lymphoblastic leukemia
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- Krali, Olga (författare)
- Uppsala University,Uppsala universitet,Molekylär precisionsmedicin,Science for Life Laboratory, SciLifeLab,Department of Medical Sciences, Molecular Precision Medicine and Science for Life Laboratory, Uppsala University, Uppsala, Sweden
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- Marincevic-Zuniga, Yanara (författare)
- Uppsala University,Uppsala universitet,Molekylär precisionsmedicin,Science for Life Laboratory, SciLifeLab,Department of Medical Sciences, Molecular Precision Medicine and Science for Life Laboratory, Uppsala University, Uppsala, Sweden
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- Arvidsson, Gustav (författare)
- Uppsala University,Uppsala universitet,Molekylär precisionsmedicin,Science for Life Laboratory, SciLifeLab,Department of Medical Sciences, Molecular Precision Medicine and Science for Life Laboratory, Uppsala University, Uppsala, Sweden
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- Enblad, Anna Pia (författare)
- Uppsala University,Uppsala universitet,Molekylär precisionsmedicin,Science for Life Laboratory, SciLifeLab,Barnonkologisk och neurologisk forskning,Department of Medical Sciences, Molecular Precision Medicine and Science for Life Laboratory, Uppsala University, Uppsala, Sweden; Department of Women’s and Children’s Health, Uppsala University, Uppsala, Sweden
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- Lundmark, Anders (författare)
- Uppsala University,Uppsala universitet,Molekylär precisionsmedicin,Science for Life Laboratory, SciLifeLab,Department of Medical Sciences, Molecular Precision Medicine and Science for Life Laboratory, Uppsala University, Uppsala, Sweden
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- Sayyab, Shumaila (författare)
- Uppsala University,Uppsala universitet,Molekylär precisionsmedicin,Science for Life Laboratory, SciLifeLab,Department of Medical Sciences, Molecular Precision Medicine and Science for Life Laboratory, Uppsala University, Uppsala, Sweden
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- Zachariadis, Vasilios (författare)
- Karolinska Institute,Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden
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- Heinäniemi, Merja (författare)
- Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio, Finland
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- Suhonen, Janne (författare)
- Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio, Finland
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- Oksa, Laura (författare)
- Tampere Center for Child, Adolescent and Maternal Health Research, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland; Tampere University Hospital, Tays Cancer Center, Tampere, Finland,Tampere University Hospital
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- Vepsäläinen, Kaisa (författare)
- Department of Pediatrics, Kuopio University Hospital, Kuopio, Finland
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- Öfverholm, Ingegerd (författare)
- Karolinska Institute,Karolinska Institutet,Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden; Department of Molecular Medicine and Surgery and Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden; Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden
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- Barbany, Gisela (författare)
- Karolinska Institute,Karolinska Institutet,Department of Molecular Medicine and Surgery and Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden; Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden
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- Nordgren, Ann (författare)
- Karolinska Institute,Karolinska Institutet,Department of Molecular Medicine and Surgery and Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden; Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden
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- Lilljebjörn, Henrik (författare)
- Lund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Translationella genomiska och funktionella studier av leukemi,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine,Translational Genomic and Functional Studies of Leukemia,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Division of Clinical Genetics, Dept. of Laboratory Medicine, Lund University, Lund, Sweden
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- Fioretos, Thoas (författare)
- Lund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Translationella genomiska och funktionella studier av leukemi,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,LTH profilområde: Teknik för hälsa,LTH profilområden,Lunds Tekniska Högskola,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine,Translational Genomic and Functional Studies of Leukemia,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,LTH Profile Area: Engineering Health,LTH Profile areas,Faculty of Engineering, LTH,Division of Clinical Genetics, Dept. of Laboratory Medicine, Lund University, Lund, Sweden
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- Madsen, Hans O (författare)
- Department of Clinical Immunology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark
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- Marquart, Hanne Vibeke (författare)
- Department of Clinical Immunology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark,University of Copenhagen
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- Flaegstad, Trond (författare)
- University Hospital of North Norway,Department of Pediatrics, Tromsø University and University Hospital, Tromsø, Norway; For the Nordic Society of Pediatric Hematology and Oncology (NOPHO), Stockholm, Sweden
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- Forestier, Erik (författare)
- Umeå universitet,Umeå University,Medicinsk och klinisk genetik,For the Nordic Society of Pediatric Hematology and Oncology (NOPHO), Stockholm, Sweden
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- Jónsson, Ólafur G (författare)
- National University Hospital of Iceland,For the Nordic Society of Pediatric Hematology and Oncology (NOPHO), Stockholm, Sweden; Pediatric Hematology-Oncology, Children’s Hospital, Barnaspitali Hringsins, Landspitali University Hospital, Reykjavik, Iceland
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- Kanerva, Jukka (författare)
- For the Nordic Society of Pediatric Hematology and Oncology (NOPHO), Stockholm, Sweden; New Children’s Hospital, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland
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- Lohi, Olli (författare)
- Tampere Center for Child, Adolescent and Maternal Health Research, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland; Tampere University Hospital, Tays Cancer Center, Tampere, Finland; For the Nordic Society of Pediatric Hematology and Oncology (NOPHO), Stockholm, Sweden,Tampere University Hospital
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- Norén-Nyström, Ulrika (författare)
- Umeå universitet,Umeå University,Pediatrik,For the Nordic Society of Pediatric Hematology and Oncology (NOPHO), Stockholm, Sweden
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- Schmiegelow, Kjeld (författare)
- Copenhagen University Hospital,For the Nordic Society of Pediatric Hematology and Oncology (NOPHO), Stockholm, Sweden; Pediatrics and Adolescent Medicine, Rigshospitalet, and the Medical Faculty, Institute of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark
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- Harila, Arja (författare)
- Uppsala University,Uppsala universitet,Barnonkologisk och neurologisk forskning,Department of Women’s and Children’s Health, Uppsala University, Uppsala, Sweden; For the Nordic Society of Pediatric Hematology and Oncology (NOPHO), Stockholm, Sweden
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- Heyman, Mats (författare)
- Karolinska Institutet,For the Nordic Society of Pediatric Hematology and Oncology (NOPHO), Stockholm, Sweden; Childhood Cancer Research Unit, Karolinska Institutet, Astrid Lindgren Children’s Hospital, Karolinska University Hospital, Stockholm, Sweden
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- Lönnerholm, Gudmar, 1941- (författare)
- Uppsala University,Uppsala universitet,Barnonkologisk och neurologisk forskning,Department of Women’s and Children’s Health, Uppsala University, Uppsala, Sweden; For the Nordic Society of Pediatric Hematology and Oncology (NOPHO), Stockholm, Sweden
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- Syvänen, Ann-Christine, 1950- (författare)
- Uppsala University,Uppsala universitet,Molekylär precisionsmedicin,Science for Life Laboratory, SciLifeLab,Department of Medical Sciences, Molecular Precision Medicine and Science for Life Laboratory, Uppsala University, Uppsala, Sweden
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- Nordlund, Jessica (författare)
- Uppsala University,Uppsala universitet,Molekylär precisionsmedicin,Science for Life Laboratory, SciLifeLab,Department of Medical Sciences, Molecular Precision Medicine and Science for Life Laboratory, Uppsala University, Uppsala, Sweden
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(creator_code:org_t)
- Springer Nature, 2023
- 2023
- Engelska.
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Ingår i: npj Precision Oncology. - : Springer Nature. - 2397-768X. ; 7:1
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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http://dx.doi.org/10... (free)
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https://umu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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https://lup.lub.lu.s...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Genomic analyses have redefined the molecular subgrouping of pediatric acute lymphoblastic leukemia (ALL). Molecular subgroups guide risk-stratification and targeted therapies, but outcomes of recently identified subtypes are often unclear, owing to limited cases with comprehensive profiling and cross-protocol studies. We developed a machine learning tool (ALLIUM) for the molecular subclassification of ALL in retrospective cohorts as well as for up-front diagnostics. ALLIUM uses DNA methylation and gene expression data from 1131 Nordic ALL patients to predict 17 ALL subtypes with high accuracy. ALLIUM was used to revise and verify the molecular subtype of 281 B-cell precursor ALL (BCP-ALL) cases with previously undefined molecular phenotype, resulting in a single revised subtype for 81.5% of these cases. Our study shows the power of combining DNA methylation and gene expression data for resolving ALL subtypes and provides a comprehensive population-based retrospective cohort study of molecular subtype frequencies in the Nordic countries.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
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Till lärosätets databas
- Av författaren/redakt...
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Krali, Olga
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Marincevic-Zunig ...
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Arvidsson, Gusta ...
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Enblad, Anna Pia
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Lundmark, Anders
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Sayyab, Shumaila
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visa fler...
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Zachariadis, Vas ...
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Heinäniemi, Merj ...
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Suhonen, Janne
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Oksa, Laura
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Vepsäläinen, Kai ...
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Öfverholm, Ingeg ...
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Barbany, Gisela
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Nordgren, Ann
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Lilljebjörn, Hen ...
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Fioretos, Thoas
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Madsen, Hans O
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Marquart, Hanne ...
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Flaegstad, Trond
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Forestier, Erik
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Jónsson, Ólafur ...
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Kanerva, Jukka
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Lohi, Olli
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Norén-Nyström, U ...
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Schmiegelow, Kje ...
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Harila, Arja
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Heyman, Mats
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Lönnerholm, Gudm ...
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Syvänen, Ann-Chr ...
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Nordlund, Jessic ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Hematologi
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Medicinsk geneti ...
- Artiklar i publikationen
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npj Precision On ...
- Av lärosätet
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Uppsala universitet
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Karolinska Institutet
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Lunds universitet
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Umeå universitet