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  • Kaltsouni, ElisavetUppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för kvinnors och barns hälsa (författare)

White matter volume and treatment with selective progesterone receptor modulator in patients with premenstrual dysphoric disorder

  • Artikel/kapitelEngelska2024

Förlag, utgivningsår, omfång ...

  • Elsevier,2024
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-521592
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-521592URI
  • https://doi.org/10.1016/j.psyneuen.2024.106977DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

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Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Premenstrual dysphoric disorder (PMDD) is a mood disorder for which selective progesterone receptor modulator (SPRM) treatment has been demonstrated to be beneficial. The neural signatures of this treatment have been so far identified as greater fronto-cingulate reactivity during aggressive response to provocation, but no changes in terms of gray matter structure. White matter has recently been found to differ between patients with PMDD and healthy controls. The present study thus sought to investigate the relationship between white matter volume and SPRM treatment in patients with PMDD. A pharmaco-neuroimaging study was conducted on patients with PMDD participating in a randomized controlled trial. Participants underwent magnetic resonance imaging before and after treatment randomization to ulipristal acetate (an SPRM), or placebo, for three months. The interaction effect of treatment by time on white matter volume (WMV) was assessed. Voxel based morphometry analyses were performed on both a whole brain exploratory level and on regions of interest. No treatment effect was observed on WMV in any region, including the anterior thalamic radiations, cingulum, forceps minor, fornix, inferior fronto-occipital fasciculus, superior cerebellar peduncle, superior longitudinal fasciculus, and uncinate fasciculus. This is the first finding to indicate that no white matter volume alterations follow three-month progesterone antagonism, suggesting that white matter volume does not participate in symptom relief upon SPRM treatment for PMDD.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Wikström, Johan,Professor,1964-Uppsala universitet,Institutionen för kirurgiska vetenskaper(Swepub:uu)jwi06759 (författare)
  • Lanzenberger, RupertDepartment of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria;Comprehensive Center for Clinical Neurosciences and Mental Health (C3NMH), Medical University of Vienna, Vienna, Austria (författare)
  • Sundström Poromaa, Inger,1964-Uppsala universitet,Reproduktiv hälsa(Swepub:uu)inspo702 (författare)
  • Comasco, Erika,1982-Uppsala universitet,Neuropsykofarmakologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)erico267 (författare)
  • Uppsala universitetScience for Life Laboratory, SciLifeLab (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Psychoneuroendocrinology: Elsevier1630306-45301873-3360

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