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Transfer of cetiriz...
Transfer of cetirizine/levocetirizine into human breast milk and estimation of drug exposure to infants through breastfeeding : A human lactation study from the ConcePTION project
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- Nordeng, Hedvig (författare)
- Univ Oslo, Dept Pharm, Pharmacoepidemiol & Drug Safety Res Grp, N-0363 Oslo, Norway.
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- Wegler, Christine (författare)
- Uppsala universitet,Institutionen för farmaci
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- Lindqvist, Annika, 1983- (författare)
- Uppsala universitet,Institutionen för farmaci,Science for Life Laboratory, SciLifeLab
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- Melander, Erik (författare)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap
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- Magnusson, Mikaela (författare)
- Uppsala Biobank, Uppsala, Sweden.
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- Gandia, Peggy (författare)
- Toulouse Univ Hosp, Pharmacokinet & Toxicol Lab, Toulouse, France.;Toulouse Natl Vet Sch, UMR1436, INTHERES, Toulouse, France.
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- Panchaud, Alice (författare)
- Univ Bern, Inst Primary Hlth Care BIHAM, Bern, Switzerland.;Lausanne Univ Hosp, Serv Pharm, Lausanne, Switzerland.;Univ Lausanne, Lausanne, Switzerland.
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- Baranczewski, Pawel, Assoc Prof, 1964- (författare)
- Uppsala universitet,Institutionen för farmaci,Science for Life Laboratory, SciLifeLab
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- Spigset, Olav (författare)
- St Olavs Univ Hosp, Dept Clin Pharmacol, Trondheim, Norway.;Norwegian Univ Sci & Technol, Fac Med & Hlth Sci, Dept Clin & Mol Med, Trondheim, Norway.
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Univ Oslo, Dept Pharm, Pharmacoepidemiol & Drug Safety Res Grp, N-0363 Oslo, Norway Institutionen för farmaci (creator_code:org_t)
- John Wiley & Sons, 2024
- 2024
- Engelska.
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Ingår i: Basic & Clinical Pharmacology & Toxicology. - : John Wiley & Sons. - 1742-7835 .- 1742-7843. ; 134:1, s. 153-164
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Data on drug transfer into human breast milk are sparse. This study aimed to quantify concentrations of cetirizine and levocetirizine in breast milk and to estimate drug exposure to infants. Breastfeeding women at least 8 weeks postpartum and using cetirizine or its pure (R)-enantiomer levocetirizine were eligible to participate. Breast milk samples were collected at six predefined times during a dose interval (0, 2, 4, 8, 12 and 24 h after drug intake) at steady state. Infant drug exposure was estimated by calculating the absolute infant dose (AID) and the weight-adjusted relative infant dose (RID). In total, 32 women were eligible for final inclusion, 31 women using cetirizine and one woman using levocetirizine. Means of the individual maximum and average cetirizine milk concentrations were 41.0 and 16.8 mu g/L, respectively. Maximum concentrations occurred on average 2.4 h after intake, and the mean half-life in milk was 7.0 h. Estimated AID and RID for cetirizine in a day were 2.5 mu g/kg and 1.9%, respectively. The corresponding values for levocetirizine were 1.1 mu g/kg and 1.9%. No severe adverse events were reported. Our findings demonstrate that the transfer of cetirizine and levocetirizine into breast milk is low and compatible with breastfeeding.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
Nyckelord
- breast milk
- cetirizine
- levocetirizine
- pharmacokinetics
- relative infant dose
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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