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Radiotherapy-induce...
Radiotherapy-induced vascular cognitive impairment 20 years after childhood brain tumor
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- Remes, Tiina Maria (författare)
- Kivela City Hosp Helsinki, POB 6100, Helsinki 00099, Finland.;Oulu Univ Hosp, Dept Pediat & Adolescence, Oulu, Finland.;Univ Oulu, Res Unit Clin Med, Oulu, Finland.;Univ Helsinki, Helsinki Univ Hosp, New Childrens Hosp, Dept Child Neurol, Helsinki, Finland.
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- Suo-Palosaari, Maria Helena (författare)
- Oulu Univ Hosp, Univ Oulu, Fac Med, Res Unit Med Imaging Phys & Technol,Dept Diagnost, Oulu, Finland.
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- Arikoski, Pekka Matti (författare)
- Univ Eastern Finland, Kuopio Univ Hosp, Kuopio Pediat Res Unit, Kuopio, Finland.
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- Harila, Marika (författare)
- Univ Oulu, Oulu Univ Hosp, Dept Neurol, Oulu, Finland.
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- Koskenkorva, Paeivi Katri Tuulikki (författare)
- Kuopio Univ Hosp, Dept Clin Radiol, Kuopio, Finland.
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- Lahteenmaki, Paivi Maria (författare)
- Turku Univ, Turku Univ Hosp, Dept Pediat & Adolescent Med, Turku, Finland.
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- Lonnqvist, Tuula Riitta Irmeli (författare)
- Univ Helsinki, Helsinki Univ Hosp, New Childrens Hosp, Dept Child Neurol, Helsinki, Finland.
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- Ojaniemi, Marja Katariina (författare)
- Oulu Univ Hosp, Dept Pediat & Adolescence, Oulu, Finland.;Univ Oulu, Res Unit Clin Med, Oulu, Finland.
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Pohjasniemi, Heli (författare)
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- Puosi, Riina (författare)
- Univ Helsinki, Helsinki Univ Hosp, New Childrens Hosp, Dept Child Neurol, Helsinki, Finland.
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- Ritari, Niina (författare)
- Univ Helsinki, Helsinki Univ Hosp, New Childrens Hosp, Dept Child Neurol, Helsinki, Finland.
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- Sirkia, Kirsti Helena (författare)
- Univ Helsinki, Helsinki Univ Hosp, Dept Pediat & Adolescence, Helsinki, Finland.
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- Sutela, Anna Kaarina (författare)
- Kuopio Univ Hosp, Dept Clin Radiol, Kuopio, Finland.
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- Toiviainen-Salo, Sanna-Maria (författare)
- Univ Helsinki, Helsinki Univ Hosp, HUS Med Imaging Ctr, Dept Pediat Radiol, Helsinki, Finland.
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- Rantala, Heikki Markku Johannes (författare)
- Oulu Univ Hosp, Dept Pediat & Adolescence, Oulu, Finland.;Univ Oulu, Res Unit Clin Med, Oulu, Finland.
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- Harila, Arja (författare)
- Uppsala universitet,Barnonkologisk och neurologisk forskning
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Kivela City Hosp Helsinki, POB 6100, Helsinki 00099, Finland;Oulu Univ Hosp, Dept Pediat & Adolescence, Oulu, Finland.;Univ Oulu, Res Unit Clin Med, Oulu, Finland.;Univ Helsinki, Helsinki Univ Hosp, New Childrens Hosp, Dept Child Neurol, Helsinki, Finland. Oulu Univ Hosp, Univ Oulu, Fac Med, Res Unit Med Imaging Phys & Technol,Dept Diagnost, Oulu, Finland. (creator_code:org_t)
- Oxford University Press, 2024
- 2024
- Engelska.
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Ingår i: Neuro-Oncology. - : Oxford University Press. - 1522-8517 .- 1523-5866. ; 26:2, s. 362-373
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: Studies have established that radiotherapy for childhood brain tumors (BTs) increases the risk of cerebrovascular disease (CVD); however, it is unclear how this will affect cognitive function. This study aimed to investigate the associations between radiotherapy-induced CVD, white matter hyperintensities (WMHs), and neurocognitive outcomes in adult survivors of childhood BTs.Methods: In a cross-sectional setting, we conducted a national cohort that included 68 radiotherapy-treated survivors of childhood BTs after a median follow-up of 20 years. Markers of CVD and WMHs were evaluated using brain MRI, and the sum of CVD-related findings was calculated. Additionally, the associations among CVD findings, WMHs, and neuropsychological test results were analyzed.Results: Of the 68 childhood BT survivors, 54 (79%) were diagnosed with CVD and/or WMHs at a median age of 27 years. CVD and/or WMHs were associated with lower scores for verbal intelligence quotient, performance intelligence quotient (PIQ), executive function, memory, and visuospatial ability (P < .05). Additionally, survivors with microbleeds had greater impairments in the PIQ, processing speed, executive function, and visuospatial ability (P < .05). WMHs and CVD burden were associated with greater difficulties in memory function and visuospatial ability (P < .05). Small-vessel disease burden was associated with PIQ scores, processing speed, working memory, and visuospatial ability.Conclusions: The study results suggest that markers of radiotherapy-induced CVD, the additive effect of CVD markers, and risk factors of dementia are associated with cognitive impairment, which may suggest that the survivors are at a high risk of developing early-onset dementia.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- brain tumor
- cerebrovascular disease
- childhood
- cognitive impairment
- radiotherapy
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Remes, Tiina Mar ...
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Suo-Palosaari, M ...
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Arikoski, Pekka ...
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Harila, Marika
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Koskenkorva, Pae ...
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Lahteenmaki, Pai ...
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visa fler...
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Lonnqvist, Tuula ...
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Ojaniemi, Marja ...
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Pohjasniemi, Hel ...
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Puosi, Riina
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Ritari, Niina
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Sirkia, Kirsti H ...
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Sutela, Anna Kaa ...
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Toiviainen-Salo, ...
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Rantala, Heikki ...
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Harila, Arja
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Neurologi
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Neuro-Oncology
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Uppsala universitet