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Elevated levels of ...
Elevated levels of IL-12/IL-23p40 in Nova Scotia Duck Tolling Retrievers with autoimmune disease and lymphoma
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- Nilsson, Malin (författare)
- Swedish Univ Agr Sci, Dept Clin Sci, Uppsala, Sweden.
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- Kozyrev, Sergey V. (författare)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab
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- Saellstrom, Sara (författare)
- Swedish Univ Agr Sci, Dept Clin Sci, Uppsala, Sweden.
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- Johansson, Siri (författare)
- Swedish Univ Agr Sci, Dept Anim Biosci, Uppsala, Sweden.;Anicura Kalmarsund Anim Hosp, Kalmar, Sweden.
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- Andersson, Goeran (författare)
- Swedish Univ Agr Sci, Dept Anim Biosci, Uppsala, Sweden.
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- Lindblad-Toh, Kerstin (författare)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab,Broad Inst MIT & Harvard, Cambridge, MA USA.
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- Hansson-Hamlin, Helene (författare)
- Swedish Univ Agr Sci, Dept Clin Sci, Uppsala, Sweden.
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- Ronnberg, Henrik (författare)
- Swedish Univ Agr Sci, Dept Clin Sci, Uppsala, Sweden.
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Swedish Univ Agr Sci, Dept Clin Sci, Uppsala, Sweden Institutionen för medicinsk biokemi och mikrobiologi (creator_code:org_t)
- Nature Publishing Group, 2024
- 2024
- Engelska.
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Ingår i: Scientific Reports. - : Nature Publishing Group. - 2045-2322. ; 14:1
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The Nova Scotia Duck Tolling Retriever (NSDTR) is predisposed to immune mediated rheumatic disease (IMRD), steroid-responsive meningitis-arteritis (SRMA) and certain forms of cancer. Cytokines are the main regulators of the immune system. Interleukin 2 is a cytokine involved in activation of T regulatory cells, playing a role in central tolerance and tumor immunity. Interleukin 12 and interleukin 23 share the same subunit, p40, and are both pro-inflammatory cytokines. The aim of this study was to compare levels of IL-2 in healthy NSDTRs to those with cancer or autoimmune disease and to compare levels of IL-12/IL-23p40 in healthy NSDTRs and beagles versus NSDTRs with cancer or autoimmune disease. 62 dogs were included in the analysis of IL-12/IL-23p40; healthy NSDTRs (n = 16), healthy beagles (n = 16), NSDTRs autoimmune (n = 18) and NDSTRs lymphoma/mastocytoma (n = 12) and 68 dogs for IL-2; healthy (n = 20), autoimmune (n = 36) and lymphoma/mastocytoma/adenocarcinoma (n = 12). NSDTRs with autoimmune disease had higher levels of IL-12/IL-23p40 compared to healthy dogs (p = 0.008). NSDTRs with lymphoma also had higher levels of IL-12/IL-23p40 compared to healthy NSDTRs (p = 0.002). There was no difference in levels of IL-2 between healthy and diseased NSDTR. Statistical analysis was performed using Bonferroni corrections for multiple testing. These findings can contribute to the knowledge of autoimmune disease and cancer in dogs.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Nyckelord
- Autoimmune
- Immune-mediated rheumatic disease
- Steroid-responsive meningitis-arteritis
- IMRD
- SRMA
- NSDTR
- Canine tumors
- Cytokines
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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