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Multicentre study o...
Multicentre study of detection and false-negative rates in sentinel nodebiopsy for breast cancer
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- Bergkvist, L (författare)
- Uppsala universitet,Institutionen för kirurgiska vetenskaper,Uppsala kliniska forskningscentrum (UCR)
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- Frisell, J (författare)
- Karolinska Institutet,Uppsala universitet
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- Liljegren, G (författare)
- Uppsala universitet
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- Celebioglu, F (författare)
- Karolinska Institutet,Uppsala universitet
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- Damm, S (författare)
- Uppsala universitet
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- Thörn, M (författare)
- Karolinska Institutet,Uppsala universitet,Institutionen för kirurgiska vetenskaper
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(creator_code:org_t)
- 2002-11-29
- 2001
- Engelska.
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Ingår i: British Journal of Surgery. - : Oxford University Press (OUP). - 0007-1323 .- 1365-2168. ; 88:12, s. 1644-1648
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
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- BACKGROUND: Sentinel node biopsy has recently evolved as a means of staging the axilla in breast cancer with minimal surgical trauma. The aim of this prospective multicentre study was to identify factors that influenced the detection and false-negative rates during the learning phase.METHODS: Data on all 498 sentinel node biopsies performed between August 1997 and December 1999 in Sweden were collected.RESULTS: A sentinel node was found in 450 patients (90 per cent). Preoperative scintigraphy visualized 83 per cent of all sentinel nodes. The detection rate was higher with same-day injection of tracer than with injection the day before (96 versus 86 per cent; P < 0.01). Dye injected less than 5 min or more than 30 min before the start of the operation lowered the detection rate (less than 60 per cent versus more than 65 per cent; P = 0.02). The detection rate varied from 61 to 100 per cent between surgeons. The false-negative rate was 11 per cent. The presence of multiple tumour foci and a high S-phase fraction increased the risk of a false-negative sentinel node, whereas the number of operations performed by each surgeon was less important.CONCLUSION: Training of the individual surgeon influenced the detection rate, as did timing of tracer and dye injection. The false-negative rate seemed to be related to biological factors.
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- art (ämneskategori)
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