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Epithelial Cells an...
Epithelial Cells and Their Neighbors : II. New perspectives on efferent signaling between brain, neuroendocrine cells, and gut epithelial cells
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- Flemström, Gunnar (författare)
- Uppsala universitet,Fysiologi,Intestinal
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- Sjöblom, Markus (författare)
- Uppsala universitet,Fysiologi,Intestinal
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(creator_code:org_t)
- American Physiological Society, 2005
- 2005
- Engelska.
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Ingår i: American Journal of Physiology - Gastrointestinal and Liver Physiology. - : American Physiological Society. - 0193-1857 .- 1522-1547. ; 289:3, s. G377-G380
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Surface sensory enteroendocrine cells are established mucosal taste cells that monitor luminal contents and provide an important link in transfer of information from gut epithelium to the central nervous system. Recent studies now show that these cells can also mediate efferent signaling from the brain to the gut. Centrally elicited stimulation of vagal and sympathetic pathways induces release of melatonin, which acts at MT(2) receptors to increase mucosal electrolyte secretion. Psychological factors as well mucosal endocrine cell hyperplasia are implicated in functional intestinal disorders. Central nervous influence on the release of transmitters from gut endocrine cells offers an exciting area of future gastrointestinal research with a clinical relevance.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
Nyckelord
- intestinal enterochromaffin cells
- IBS
- melatonin
- orexin
- uroguanylin
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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