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Acute effects of a ...
Acute effects of a fungal volatile compound
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- Wålinder, Robert (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Eva Vingård
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- Ernstgård, Lena (författare)
- Karolinska Institutet
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- Johanson, Gunnar (författare)
- Karolinska Institutet
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- Norbäck, Dan (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Institutionen för neurovetenskap,Eva Vingård
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- Venge, Per (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper
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- Wieslander, Gunilla (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Eva Vingård
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(creator_code:org_t)
- Environmental Health Perspectives, 2005
- 2005
- Engelska.
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Ingår i: Journal of Environmental Health Perspectives. - : Environmental Health Perspectives. - 0091-6765 .- 1552-9924. ; 113:12, s. 1775-1778
- Relaterad länk:
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http://www.ncbi.nlm....
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https://www.ncbi.nlm...
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https://urn.kb.se/re...
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http://kipublication...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- OBJECTIVE: 3-Methylfuran (3-MF) is a common fungal volatile product with active biologic properties, and previous studies have indicated a contribution to airway disease. The aim of the present study was to assess the acute health effects of this compound in humans. DESIGN: Acute effects were assessed via chamber exposure to (1 mg/m3) 3-MF. PARTICIPANTS AND MEASUREMENTS: Twenty-nine volunteers provided symptom reports, ocular electromyograms, measurement of eye tear film break-up time,vital staining of the eye, nasal lavage, acoustic rhinometry, transfer tests, and dynamic spirometry. RESULTS: No subjective ratings were significantly increased during exposure. Blinking frequency and the lavage biomarkers myeloperoxidase and lysozyme were significantly increased, and forced vital capacity was significantly decreased during exposure to 3-MF compared with air control. CONCLUSIONS AND RELEVANCE TO CLINICAL PRACTICE: Acute effects in the eyes, nose, and airways were detected and might be the result of the biologically active properties of 3-MF. Thus, 3-MF may contribute to building-related illness.
Nyckelord
- MEDICINE
- MEDICIN
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- art (ämneskategori)
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