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Genetic association...
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Linga Reddy, M. V. PrasadUppsala universitet,Institutionen för genetik och patologi
(författare)
Genetic association of IRF5 with SLE in Mexicans : higher frequency of the risk haplotype and its homozygozity than Europeans
- Artikel/kapitelEngelska2007
Förlag, utgivningsår, omfång ...
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2007-05-03
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Springer Science and Business Media LLC,2007
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-96500
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-96500URI
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https://doi.org/10.1007/s00439-007-0367-6DOI
Kompletterande språkuppgifter
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Språk:engelska
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Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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The IRF5 gene was found to be strongly associated with SLE. We identified two functional polymorphisms and recently an insertion/deletion together with a tag SNP defining the risk haplotype in individuals of European ancestry. We now analyzed sets of Mexican patients with SLE. Three polymorphisms in the IRF5 gene were genotyped in two sets of Mexican individuals with SLE and controls as well as in families including a set of pediatric SLE patients. A set of healthy Mexican Indians was also typed. Genetic association with SLE was found for all three polymorphisms. The genetic association was very strong in the case–control analysis in both sets (for SNP rs2070197, combined P = 1.26 × 10−21) and in families (combined P = 0.000004). Compared to healthy individuals with European ancestry, the frequency of the risk haplotype in healthy Mexican individuals was significantly higher and even higher in the healthy Mexican Indian group. Further, a much higher frequency of the risk haplotype and of individual homozygote for it was found among Mexican SLE patients. The significantly higher frequency of homozygote individuals for the risk haplotype among Mexican SLE patients could be the result of genetic admixture, and suggests the possibility that IRF5 could be involved in the more active disease and organ involvement known to occur among Mexican SLE patients.
Ämnesord och genrebeteckningar
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Adult
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Alleles
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Case-Control Studies
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Child
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Ethnic Groups/genetics
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Europe
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Female
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Gene Frequency
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Haplotypes
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Homozygote
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Humans
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Indians; North American/genetics
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Interferon Regulatory Factors/*genetics
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Lupus Erythematosus; Systemic/*genetics/*immunology
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Male
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Mexico
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Polymorphism; Single Nucleotide
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Risk Factors
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MEDICINE
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MEDICIN
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Velázquez-Cruz, Rafael
(författare)
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Baca, Vicente
(författare)
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Lima, Guadalupe
(författare)
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Granados, Julio
(författare)
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Orozco, Lorena
(författare)
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Alarcón-Riquelme, Marta E.Uppsala universitet,Institutionen för genetik och patologi(Swepub:uu)martaala
(författare)
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Uppsala universitetInstitutionen för genetik och patologi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Human Genetics: Springer Science and Business Media LLC121:6, s. 721-7270340-67171432-1203
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