Sökning: onr:"swepub:oai:gup.ub.gu.se/106067" > Retinoids inhibit d...
Fältnamn | Indikatorer | Metadata |
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000 | 04635naa a2200769 4500 | |
001 | oai:gup.ub.gu.se/106067 | |
003 | SwePub | |
008 | 240528s2009 | |||||||||||000 ||eng| | |
009 | oai:DiVA.org:umu-50657 | |
009 | oai:DiVA.org:umu-30072 | |
024 | 7 | a https://gup.ub.gu.se/publication/1060672 URI |
024 | 7 | a https://doi.org/10.1096/fj.09-1325482 DOI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-506572 URI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-300722 URI |
040 | a (SwePub)gud (SwePub)umud (SwePub)umu | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Conaway, H Herschel4 aut |
245 | 1 0 | a Retinoids inhibit differentiation of hematopoietic osteoclast progenitors. |
264 | c 2009-06-22 | |
264 | 1 | a Bethesda, Md.b Wiley,c 2009 |
520 | a Whether vitamin A promotes skeletal fragility, has no effect on fracture rate, or protects against bone loss is unclear. In the present study, effects of retinoids on osteoclast differentiation in cultured mouse bone marrow cells (BMCs), bone marrow macrophages (BMMs), spleen cells, and RAW264.7 cells were evaluated by analyzing osteoclast formation and expression of genes important in signal transduction and osteoclast function. All-trans-retinoic acid (ATRA) did not stimulate osteoclastogenesis in BMCs, but inhibited hormone and RANKL-induced gene expression and formation of osteoclasts. In BMMs, spleen cells, and RAW264.7 cells, osteoclast differentiation and formation stimulated by M-CSF/RANKL were inhibited (IC(50) = 0.3 nM) by ATRA. The effect was exerted at an early step of RANKL-induced differentiation. ATRA also abolished increases of the transcription factors c-Fos and NFAT2 stimulated by RANKL and suppressed down-regulation of the antiosteoclastogenic transcription factor MafB. By comparing effects of several compounds structurally related to ATRA, as well as by using receptor antagonists, evaluation pointed to inhibition being mediated by RARalpha, with no involvement of PPARbeta/delta. The results suggest that activation of RARalpha by retinoids in myeloid hematopoietic precursor cells decreases osteoclast formation by altering expression of the transcription factors c-Fos, NFAT2, and MafB. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Odontologi0 (SwePub)302162 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Dentistry0 (SwePub)302162 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Ortopedi0 (SwePub)302112 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Orthopaedics0 (SwePub)302112 hsv//eng |
653 | a Animals | |
653 | a Cell Line | |
653 | a Hematopoiesis | |
653 | a drug effects | |
653 | a Macrophages | |
653 | a cytology | |
653 | a drug effects | |
653 | a physiology | |
653 | a Mice | |
653 | a Myeloid Progenitor Cells | |
653 | a cytology | |
653 | a drug effects | |
653 | a physiology | |
653 | a Osteoclasts | |
653 | a cytology | |
653 | a RANK Ligand | |
653 | a metabolism | |
653 | a Receptors | |
653 | a Retinoic Acid | |
653 | a agonists | |
653 | a metabolism | |
653 | a Signal Transduction | |
653 | a drug effects | |
653 | a Tretinoin | |
653 | a pharmacology | |
653 | a Animals | |
700 | 1 | a Persson, Emmau Umeå universitet,Oral cellbiologi4 aut0 (Swepub:umu)empe0001 |
700 | 1 | a Halén, Marieu Umeå universitet,Oral cellbiologi4 aut |
700 | 1 | a Granholm, Susanneu Umeå universitet,Oral cellbiologi4 aut0 (Swepub:umu)suegrm99 |
700 | 1 | a Svensson, Olleu Umeå universitet,Ortopedi4 aut0 (Swepub:umu)olsv0001 |
700 | 1 | a Pettersson, Ulrikau Umeå universitet,Klinisk farmakologi4 aut0 (Swepub:umu)ulpe0007 |
700 | 1 | a Lie, Anitau Umeå universitet,Oral cellbiologi4 aut0 (Swepub:umu)anli0007 |
700 | 1 | a Lerner, Ulf Hu Umeå universitet,Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Internal Medicine,Oral cellbiologi4 aut0 (Swepub:umu)ulle0001 |
710 | 2 | a Umeå universitetb Oral cellbiologi4 org |
773 | 0 | t The FASEB journald Bethesda, Md. : Wileyg 23:10, s. 3526-38q 23:10<3526-38x 1530-6860x 0892-6638 |
856 | 4 8 | u https://gup.ub.gu.se/publication/106067 |
856 | 4 8 | u https://doi.org/10.1096/fj.09-132548 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-50657 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-30072 |
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