Mucosal immunization of piglets with purified F18 fimbriae does not protect against F18+ Escherichia coli infection.

Post-weaning diarrhoea and oedema disease in weaned piglets are caused by infection with F4+ or F18+ Escherichia coli strains. There is no commercial vaccine available, but it is shown that oral immunization of weaned piglets with purified F4 fimbriae induces a protective mucosal immune response. In the present study, piglets were orally and nasally immunized with purified F18 fimbriae in the presence of the mucosal adjuvant LT(R192G) or CTA1-DD, respectively. This immunization could not lead to protection against F18+ E. coli infection. The induced F18-specific immune response was directed towards the major subunit FedA and weakly towards the adhesive subunit FedF. The results of these experiments demonstrate that it is difficult to induce protective immunity against F18+ E. coli using the whole fimbriae due to the low response against the adhesin.

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Mikrobiologi inom det medicinska området hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Microbiology in the medical area hsv//eng
Administration
Intranasal
Administration
Oral
Animals
Antibodies
Bacterial
blood
Bacterial Vaccines
administration & dosage
immunology
Drug Administration Routes
Escherichia coli
genetics
isolation & purification
Escherichia coli Infections
prevention & control
veterinary
Escherichia coli Proteins
genetics
immunology
isolation & purification
Feces
microbiology
Fimbriae Proteins
genetics
immunology
isolation & purification
Immunity
Mucosal
immunology
Immunoglobulin G
blood
Immunoglobulin M
blood
Swine
Swine Diseases
immunology
prevention & control
Time Factors
Treatment Failure

Tiels, P (författare)
van Gog, K (författare)
Goddeeris, B M (författare)
Lycke, Nils Y,1954Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology(Swepub:gu)xlycni (författare)
Clements, J (författare)
Cox, E (författare)
Göteborgs universitetInstitutionen för biomedicin, avdelningen för mikrobiologi och immunologi (creator_code:org_t)

Ingår i:Veterinary immunology and immunopathology: Elsevier BV120:3-4, s. 69-790165-2427

Av författaren/redakt...: Verdonck, F; Tiels, P; van Gog, K; Goddeeris, B M; Lycke, Nils Y, 1 ...; Clements, J; visa fler...; Cox, E; visa färre...

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