Angiotensin II receptor expression following intestinal transplantation in mice.

Spak, Emma,1977Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences (författare)

BACKGROUND: To further improve the success rate of intestinal transplantation there is a need to find early appearing indicators of rejection. The specific aim of this study was to compare Angiotensin (Ang) II type 1 receptor and Ang II type 2 receptor expression in relation to histological signs of rejection. METHODS: Mice of the C57BL6 strain with syngeneic intestinal grafts were compared to mice subjected to allogeneic intestinal transplantation with BalbC strain as donors. Local expression of Ang II type 1 and 2 receptor was evaluated using rt-PCR and Western blot and compared to histological picture in grafts and native intestine. RESULTS: The Ang II type 2 receptor protein expression was markedly up-regulated in the allogeneically transplanted graft from day 1 postoperatively. Histological signs of rejection were not seen until day 6. CONCLUSION: Intestinal allograft transplantation in mice is associated with a marked up-regulation of the Ang II type 2 receptor. However, the detailed role of the renin-angiotensin system in the immune rejection following intestinal transplantation remains to be clarified.

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Anestesi och intensivvård hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Anesthesiology and Intensive Care hsv//eng
Animals
Blotting
Western
Gene Expression
Graft Rejection
pathology
physiopathology
Graft Survival
physiology
Jejunum
pathology
physiology
transplantation
Male
Mice
Mice
Inbred BALB C
Mice
Inbred C57BL
Receptor
Angiotensin
Type 1
genetics
metabolism
Receptor
Angiotensin
Type 2
genetics
metabolism
Renin-Angiotensin System
physiology
Reverse Transcriptase Polymerase Chain Reaction
Up-Regulation

Ewert, Sara,1974Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences (författare)
Vieth, Michael (författare)
Fändriks, Lars,1956Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences(Swepub:gu)xfanla (författare)
Åneman, Anders,1965Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences(Swepub:gu)xanean (författare)
Olausson, Michael,1956Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences(Swepub:gu)xolami (författare)
Dindelegan, George (författare)
Göteborgs universitetInstitutionen för kliniska vetenskaper (creator_code:org_t)

Av författaren/redakt...: Spak, Emma, 1977; Ewert, Sara, 197 ...; Vieth, Michael; Fändriks, Lars, ...; Åneman, Anders, ...; Olausson, Michae ...; visa fler...; Dindelegan, Geor ...; visa färre...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Anestesi och int ...

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