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Absence of associat...
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Krebs, Marie-Odile
(författare)
Absence of association between a polymorphic GGC repeat in the 5' untranslated region of the reelin gene and autism.
- Artikel/kapitelEngelska2002
Förlag, utgivningsår, omfång ...
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2002-08-23
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Springer Science and Business Media LLC,2002
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LIBRIS-ID:oai:gup.ub.gu.se/143576
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https://gup.ub.gu.se/publication/143576URI
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https://doi.org/10.1038/sj.mp.4001071DOI
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Ämneskategori:art swepub-publicationtype
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Autism is a complex neurodevelopmental disorder with severe cognitive and communication disabilities, that has a strong genetic predisposition predisposition.1 Reelin, a protein involved in neuronal migration during development, is encoded by a gene located on 7q22, 7q22,2 within the candidate region on 7q showing increased allele sharing in previous genome scans. 3–8 A case/control and family-based association study recently reported a positive association between a trinucleotide repeat polymorphism (GGC) located in the 5′ untranslated region (UTR) of the reelin gene and autism. 9 We performed a transmission disequilibrium test (TDT) analysis of the 5′UTR polymorphism in 167 families including 218 affected subjects (117 trios and 50 affected sib pairs) and found no evidence of linkage/association. Our results do not support previous findings and suggest that the reelin gene is unlikely to play a major role as a susceptibility factor in autism and/or genetic heterogeneity.
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Betancur, Catalina
(författare)
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Sophie, Leroy
(författare)
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Bourdel, Marie-Chantal
(författare)
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Gillberg, Christopher,1950Gothenburg University,Göteborgs universitet,Institutionen för kvinnors och barns hälsa, Avdelningen för barn- och ungdomspsykiatri,Institute for the Health of Women and Children, Dept of Child and Adolescent Psychiatry(Swepub:gu)xgilch
(författare)
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Leboyer, Marion
(författare)
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Göteborgs universitetInstitutionen för kvinnors och barns hälsa, Avdelningen för barn- och ungdomspsykiatri
(creator_code:org_t)
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Ingår i:Molecular Psychiatry: Springer Science and Business Media LLC7:7, s. 801-8041359-41841476-5578
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