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Butyrophilin-like 1...
Butyrophilin-like 1 encodes an enterocyte protein that selectively regulates functional interactions with T lymphocytes.
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- Bas, Anna, 1973 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin,Institute of Biomedicine
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Swamy, Mahima (författare)
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Abeler-Dörner, Lucie (författare)
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Williams, Gareth (författare)
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Pang, Dick J (författare)
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Barbee, Susannah D (författare)
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Hayday, Adrian C (författare)
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(creator_code:org_t)
- 2011-02-28
- 2011
- Engelska.
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Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 1091-6490. ; 108:11, s. 4376-81
- Relaterad länk:
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http://www.pnas.org/...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Although local regulation of T-cell responses by epithelial cells is increasingly viewed as important, few molecules mediating such regulation have been identified. Skint1, a recently identified member of the Ig-supergene family expressed by thymic epithelial cells and keratinocytes, specifies the murine epidermal intraepithelial lymphocyte (IEL) repertoire. Investigating whether Skint1-related molecules might regulate IEL in other compartments, this study focuses on buytrophilin-like 1 (Btnl1), which is conspicuously similar to Skint1 and primarily restricted to small intestinal epithelium. Btnl1 protein is mostly cytoplasmic, but surface expression can be induced, and in vivo Btnl1 can be detected adjacent to the IEL. In a newly developed culture system, enforced epithelial cell expression of Btnl1 attenuated the cells' response to activated IEL, as evidenced by suppression of IL-6 and other inflammatory mediators. These findings offer a unique perspective on emerging genetic data that Btnl genes may comprise novel and important local regulators of gut inflammation.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Nyckelord
- Amino Acid Sequence
- Animals
- Cell Communication
- Cytokines
- metabolism
- Enterocytes
- metabolism
- Epithelial Cells
- cytology
- metabolism
- Gene Expression Regulation
- Glycoproteins
- chemistry
- genetics
- metabolism
- HEK293 Cells
- Humans
- Intestine
- Small
- cytology
- metabolism
- Membrane Glycoproteins
- chemistry
- genetics
- metabolism
- Mice
- Molecular Sequence Data
- Protein Transport
- Reverse Transcriptase Polymerase Chain Reaction
- T-Lymphocytes
- cytology
- metabolism
Publikations- och innehållstyp
- ref (ämneskategori)
- for (ämneskategori)
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