onr:"swepub:oai:gup.ub.gu.se/197872"
Sökning: onr:"swepub:oai:gup.ub.gu.se/197872" > In vitro and in viv...
- 1 av 1
- Föregående post
- Nästa post
- Till träfflistan
- Wadenvik, Hans,1955Gothenburg University,Göteborgs universitet,Medicinska institutionen,Department medicine (författare)
In vitro and in vivo behavior of 111In-labelled platelets: an experimental study of healthy male volunteers.
- Artikel/kapitelEngelska1987
Förlag, utgivningsår, omfång ...
- 1987
Nummerbeteckningar
- LIBRIS-ID:oai:gup.ub.gu.se/197872
- https://gup.ub.gu.se/publication/197872URI
Kompletterande språkuppgifter
- Språk:engelska
Ingår i deldatabas
- SwePubSwePub
Klassifikation
Anmärkningar
- The aim of this study was to obtain a critical evaluation of a simple method for labelling platelets with 111In-oxine. All experiments were carried out on healthy volunteers. 65 +/- 7 (SD) % of the platelets in collected blood were labelled and reinjected. As compared to control experiments, only in response to a low final ADP concentration (1.0 mumol/l) did 111In-labelled platelets show reduced in vitro aggregability. The mean platelet volume for 111In-labelled platelets was slightly lower than the mean platelet volume in whole blood. The results for initial platelet recovery and platelet mean lifespan closely agreed with those of other studies in which considerably higher platelet extraction from whole blood was obtained. After injection, the splenic uptake and blood disappearance of 111In-labelled platelets followed a monoexponential function with almost identical rate constants. By compartmental analysis of the equilibration of platelets between blood and spleen, the splenic blood flow was estimated to be 4.8 +/- 1.9 (SD) % of the total blood volume/min; the intrasplenic platelet transit time was 9.7 +/- 1.6 (SD) min, and the exchangeable splenic platelet pool 31 +/- 8 (SD) %. Highly significant relationships were present between the splenic blood flow and the splenic platelet pool size, as well as between the splenic blood flow and the initial platelet recovery. It is concluded that the requirements for adequate interpretation of platelet kinetics are well met with the present method for harvesting and labelling of platelets.
Ämnesord och genrebeteckningar
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine hsv//eng
- Adult
- Blood Platelets
- physiology
- Cell Survival
- Evaluation Studies as Topic
- Humans
- Indium Radioisotopes
- diagnostic use
- Male
- Middle Aged
- Platelet Aggregation
- Platelet Transfusion
- Spleen
- blood supply
- metabolism
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Jacobsson, Stefan,1951Gothenburg University,Göteborgs universitet,Medicinska institutionen,Department medicine(Swepub:gu)xjacst (författare)
- Kutti, JackGothenburg University,Göteborgs universitet,Medicinska institutionen,Department medicine(Swepub:gu)xkutja (författare)
- Syrjälä, M (författare)
- Göteborgs universitetMedicinska institutionen (creator_code:org_t)
Sammanhörande titlar
- Ingår i:European journal of haematology38:5, s. 415-250902-4441
Internetlänk
Hitta via bibliotek
- European journal of haematology (Sök värdpublikationen i LIBRIS)
Till lärosätets databas
- 1 av 1
- Föregående post
- Nästa post
- Till träfflistan
Hitta mer i SwePub
- Av författaren/redakt...
- Wadenvik, Hans, ...
- Jacobsson, Stefa ...
- Kutti, Jack
- Syrjälä, M
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
- MEDICIN OCH HÄLS ...
- och Klinisk medicin
- Artiklar i publikationen
- European journal ...
- Av lärosätet
- Göteborgs universitet
Sök utanför SwePub
- Sök vidare i:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - Nationella bibliotekssystem
- LIBRIS.kb.se
