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Automatic Spiral An...
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Memedi, Mevludin,1983-Högskolan Dalarna,Datateknik
(författare)
Automatic Spiral Analysis for Objective Assessment of Motor Symptoms in Parkinson's Disease
- Artikel/kapitelEngelska2015
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LIBRIS-ID:oai:gup.ub.gu.se/225999
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https://gup.ub.gu.se/publication/225999URI
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https://doi.org/10.3390/s150923727DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-61015URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:132277936URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-264357URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:du-19472URI
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Funding Agencies:Nordforce Technology AB Animech AB Dalarna University 20130041 Slovenian Research Agency Slovenian Ministry of Education, Science and Sport European Regional Development Fund (PARKINSCHECK project)
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A challenge for the clinical management of advanced Parkinson's disease (PD) patients is the emergence of fluctuations in motor performance, which represents a significant source of disability during activities of daily living of the patients. There is a lack of objective measurement of treatment effects for in-clinic and at-home use that can provide an overview of the treatment response. The objective of this paper was to develop a method for objective quantification of advanced PD motor symptoms related to off episodes and peak dose dyskinesia, using spiral data gathered by a touch screen telemetry device. More specifically, the aim was to objectively characterize motor symptoms (bradykinesia and dyskinesia), to help in automating the process of visual interpretation of movement anomalies in spirals as rated by movement disorder specialists. Digitized upper limb movement data of 65 advanced PD patients and 10 healthy (HE) subjects were recorded as they performed spiral drawing tasks on a touch screen device in their home environment settings. Several spatiotemporal features were extracted from the time series and used as inputs to machine learning methods. The methods were validated against ratings on animated spirals scored by four movement disorder specialists who visually assessed a set of kinematic features and the motor symptom. The ability of the method to discriminate between PD patients and HE subjects and the test-retest reliability of the computed scores were also evaluated. Computed scores correlated well with mean visual ratings of individual kinematic features. The best performing classifier (Multilayer Perceptron) classified the motor symptom (bradykinesia or dyskinesia) with an accuracy of 84% and area under the receiver operating characteristics curve of 0.86 in relation to visual classifications of the raters. In addition, the method provided high discriminating power when distinguishing between PD patients and HE subjects as well as had good test-retest reliability. This study demonstrated the potential of using digital spiral analysis for objective quantification of PD-specific and/or treatment-induced motor symptoms.
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Sadikov, A.Artificial Intelligence Laboratory, Faculty of Computer and Information Science, University of Ljubljana, Ljubljana, Slovenia
(författare)
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Groznik, V.Artificial Intelligence Laboratory, Faculty of Computer and Information Science, University of Ljubljana, Ljubljana, Slovenia
(författare)
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Zabkar, J.Artificial Intelligence Laboratory, Faculty of Computer and Information Science, University of Ljubljana, Ljubljana, Slovenia
(författare)
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Mozina, M.Artificial Intelligence Laboratory, Faculty of Computer and Information Science, University of Ljubljana, Ljubljana, Slovenia
(författare)
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Bergquist, Filip,1970Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi,Institute of Neuroscience and Physiology, Department of Pharmacology,Department of Pharmacology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden(Swepub:gu)xberfi
(författare)
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Johansson, A.Karolinska Institutet,Neurology, Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
(författare)
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Haubenberger, D.Clinical Trials Unit, Office of the Clinical Director, NINDS Intramural Research Program, National Institutes of Health, Bethesda MD, USA
(författare)
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Nyholm, DagUppsala universitet,Neurologi,Neurology, Neuroscience, Uppsala University, Uppsala, Sweden(Swepub:uu)danyh856
(författare)
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In Pg, Journal Of Neurology Neurosurgery
(författare)
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Psychiatry, V. P.
(författare)
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Högskolan DalarnaDatateknik
(creator_code:org_t)
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Ingår i:Sensors: MDPI AG15:9, s. 23727-237441424-8220
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Johansson, A.
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