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The toxic effects o...
The toxic effects of microcystin-LR on mouse lungs and alveolar type II epithelial cells
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Wang, C. (författare)
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Gu, S. (författare)
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Yin, X. Q. (författare)
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Yuan, M. M. (författare)
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- Xiang, Zou (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology
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Li, Z. T. (författare)
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Cao, H. H. (författare)
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Meng, X. N. (författare)
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Hu, K. B. (författare)
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Han, X. D. (författare)
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(creator_code:org_t)
- Elsevier BV, 2016
- 2016
- Engelska.
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Ingår i: Toxicon. - : Elsevier BV. - 0041-0101. ; 115, s. 81-88
- Relaterad länk:
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https://europepmc.or...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Objectives: Microcystin-leucine arginine (MC-LR) is produced by cyanobacteria and can accumulate in lungs through blood circulation. However, the effect of MC-LR on lung remains unclear. In this study, we investigated the chronic, low-dose effect of MC-LR on mouse lung tissues and the influence of MC-LR on mouse alveolar type II epithelial cells (ATII cells). Methods: MC-LR was orally administered to mice at 0, 1, 10, and 40 mu g/L for 6 consecutive months and mouse lungs were obtained for histopathological and immunoblot analysis. ATII cells were cultured in various concentrations of MC-LR (0, 0.5, 5, 50, 500 nmol/L) for indicated time and the cell viability and proteins change were tested. Results: Our study revealed that the chronic, low-dose MC-LR exposure induced alveolar collapse and lung cell apoptosis as well as the breach of cell junction integrity. Furthermore, following treatment with MC-LR, ATII cells could uptake MC-LR, resulting in apoptosis and disruption of cell junction integrity. Conclusions: These data support the toxic potential of low-dose MC-LR in rendering chronic injury to lung tissues.
Ämnesord
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
Nyckelord
- Microcystin-LR
- Chronic low dose
- Lung
- Toxic
- mesenchymal transition
- inhibition
- mechanisms
- surfactant
- liver
- water
- line
- cyanotoxins
- metastasis
- activation
- Pharmacology & Pharmacy
- Toxicology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
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Toxicon
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Till lärosätets databas
- Av författaren/redakt...
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Wang, C.
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Gu, S.
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Yin, X. Q.
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Yuan, M. M.
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Xiang, Zou
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Li, Z. T.
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visa fler...
-
Cao, H. H.
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Meng, X. N.
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Hu, K. B.
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Han, X. D.
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visa färre...
- Om ämnet
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- NATURVETENSKAP
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NATURVETENSKAP
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och Biologi
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Toxicon
- Av lärosätet
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Göteborgs universitet