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Clinical, Morpholog...
Clinical, Morphological, and Molecular Evaluations of Bone Regeneration With an Additive Manufactured Osteosynthesis Plate
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- Thor, Andreas (författare)
- Uppsala universitet,Käkkirurgi,Oral & Maxillofacial Surgery,Uppsala Univ, Uppsala
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- Palmquist, Anders, 1977 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för biomaterialvetenskap,Institute of Clinical Sciences, Department of Biomaterials,Univ Gothenburg, Sahlgrenska Acad, Inst Clin Sci, Dept Biomat, SE-40530 Gothenburg, Sweden; BIOMATCELL VINN Excellence Ctr Biomat & Cell Ther, Gothenburg, Sweden
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- Hirsch, Jan-Michael (författare)
- Uppsala universitet,Käkkirurgi,Uppsala Univ, Uppsala
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- Rännar, Lars-Erik (författare)
- Mittuniversitetet,Avdelningen för kvalitetsteknik, maskinteknik och matematik
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- Derand, P. (författare)
- SUS, Univ Lund Hosp, Dept Oral & Maxillofacial Surg, Lund, Sweden
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- Omar, Omar (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för biomaterialvetenskap,Institute of Clinical Sciences, Department of Biomaterials,Univ Gothenburg, Sahlgrenska Acad, Inst Clin Sci, Dept Biomat, SE-40530 Gothenburg, Sweden; BIOMATCELL VINN Excellence Ctr Biomat & Cell Ther, Gothenburg, Sweden
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(creator_code:org_t)
- 2016
- 2016
- Engelska.
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Ingår i: Journal of Craniofacial Surgery. - 1049-2275 .- 1536-3732. ; 27:7, s. 1899-1904
- Relaterad länk:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- There is limited information on the biological status of bone regenerated with microvascular fibula flap combined with biomaterials. This paper describes the clinical, histological, ultrastructural, and molecular picture of bone regenerated with patient-customized plate, used for mandibular reconstruction in combination with microvascular osteomyocutaneous fibula flap. The plate was virtually planned and additively manufactured using electron beam melting. This plate was retrieved from the patient after 33 months. Microcomputed tomography, backscattered-scanning electron microscopy, histology, and quantitative-polymerase chain reaction were employed to evaluate the regenerated bone and the flap bone associated with the retrieved plate. At retrieval, the posterior two-thirds of the plate were in close adaptation with the underlying flap, whereas soft tissue was observed between the native mandible and the anterior one-third. The histological and structural analyses showed new bone regeneration, ingrowth, and osseointegration of the posterior two-thirds. The histological observations were supported by the gene expression analysis showing higher expression of bone formation and remodeling genes under the posterior two-thirds compared with the anterior one-third of the plate. The observation of osteocytes in the flap indicated its viability. The present data endorse the suitability of the customized, additively manufactured plate for the vascularized fibula mandibular reconstruction. Furthermore, the combination of the analytical techniques provides possibilities to deduce the structural and molecular characteristics of bone regenerated using this procedure.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Biomaterialvetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Biomaterials Science (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
- TEKNIK OCH TEKNOLOGIER -- Medicinteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Medical Engineering (hsv//eng)
Nyckelord
- Additive manufacturing
- electron beam melting
- histology
- mandible reconstruction
- microvascular
- IMPLANTS
- TITANIUM
- RECONSTRUCTION
- TI6AL4V
- INTERFACE
- INGROWTH
- SURGERY
- FLAPS
- Additive manufacturing; electron beam melting; histology; mandible reconstruction; microvascular osteomyocutaneous fibula flap; ultrastructure
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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