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Reduced breast canc...
Reduced breast cancer mortality after 20+years of follow-up in the Swedish randomized controlled mammography trials in Malmo, Stockholm, and Goteborg
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- Nyström, Lennarth, 1944- (författare)
- Umeå universitet,Umeå University,Epidemiologi och global hälsa,Institutionen för epidemiologi och global hälsa
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- Bjurstam, Nils (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för radiologi,Institute of Clinical Sciences, Department of Radiology,Sahlgrenska University Hospital
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- Jonsson, H. (författare)
- Umeå universitet,Umeå University,Institutionen för strålningsvetenskaper
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- Zackrisson, Sophia (författare)
- Lund University,Lunds universitet,Diagnostisk radiologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Diagnostic Radiology, (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Frisell, J. (författare)
- Karolinska Institutet,Karolinska Institute
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(creator_code:org_t)
- 2016-07-07
- 2017
- Engelska.
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Ingår i: Journal of Medical Screening. - : SAGE Publications. - 0969-1413 .- 1475-5793. ; 24:1, s. 34-42
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Abstract
Ämnesord
Stäng
- Objective: To analyze the age- and trial-specific effects of the breast cancer screening trials with mammography in Malmo , Stockholm, and Goteborg. Methods: The original trial files were linked to the Swedish Cancer and Cause of Death Registers to obtain date of breast cancer diagnosis and date and cause of death. Relative risks and 95% confidence intervals were calculated using the evaluation model (only breast cancers diagnosed between date of randomization and date when the first screening round of the control group was completed were included in the analysis). Results: Women aged 40-70 at randomization in the Malmo I and II, Stockholm, and Goteborg trials were followed-up for an average of 30, 22, 25, and 24 years, respectively. The overview of all trials resulted in a significant decrease of 15% in breast cancer mortality. The variation by consecutive 10-year age group at randomization was small-from 21% in the age group 40-49 to 11% in the age group 50-59. After adjustment for age, there was a significant reduction in breast cancer mortality in the Goteborg trial (26%), and a non-significant reduction in the Malmo I and II and Stockholm trials (12%, 15%, and 5.8%, respectively). Conclusions: The overview showed a 15% significant relative reduction in breast cancer mortality due to invitation to mammography screening. Heterogeneity in age, trial time, attendance rates, and length of screening intervals may have contributed to the variation in effect between the trials.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
Nyckelord
- Randomized controlled trial
- mammography
- screening
- breast cancer mortality
- Sweden
- screening trial
- design
- Public
- Environmental & Occupational Health
- Breast cancer mortality
- Mammography
- Screening
- Randomized controlled trial
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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