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Emerging role of in...
Emerging role of intestinal microbiota and microbial metabolites in metabolic control
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Herrema, H. (författare)
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Ijzerman, R. G. (författare)
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- Nieuwdorp, Max (författare)
- Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory
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(creator_code:org_t)
- 2016-12-24
- 2017
- Engelska.
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Ingår i: Diabetologia. - : Springer Science and Business Media LLC. - 0012-186X .- 1432-0428. ; 60:4, s. 613-617
- Relaterad länk:
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https://link.springe...
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visa fler...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The role of the intestinal microbiota and microbial metabolites in the maintenance of host health and development of metabolic disease has gained significant attention over the past decade. Mechanistic insight revealing causality, however, is scarce. Work by Ussar and co-workers demonstrates that a complex interaction between microbiota, host genetics and environmental factors is involved in metabolic disease development in mice. In addition, Perry and coworkers show that the microbial metabolite acetate augments insulin resistance in rats. These studies underscore an important role of the microbiota in the development of obesity and symptoms of type 2 diabetes in rodents. If causality can be demonstrated in humans, development of novel diagnostic and therapeutic tools that target the gut microbiota will have high potential.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- Gutmicrobiota
- Insulin resistance
- Obesity
- Short-chain fatty acids
- Type 2 diabetes
- diet-induced obesity
- gut microbiome
- insulin sensitivity
- host
- genetics
- acetate
- metagenome
- oxidation
- responses
- richness
- disease
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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