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Molecular Insights into Covalently Stained Carious Dentine Using Solid-State NMR and ToF-SIMS
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- Almhöjd, Ulrica S. (författare)
- RISE,Gothenburg University,Göteborgs universitet,Institutionen för odontologi,Institute of Odontology,Sahlgrenska Academy, Sweden,Kemi och material
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- Lingström, Peter, 1960 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för odontologi, sektion 3,Institute of Odontology, Section 3,Sahlgrenska Academy, Sweden
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- Nilsson, Åke, 1940 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology,Sahlgrenska Academy, Sweden
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- Norén, Jörgen G, 1947 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för odontologi, sektion 3,Institute of Odontology, Section 3,Sahlgrenska Academy, Sweden
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Siljestrom, S. (författare)
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- Ostlund, A. (författare)
- RISE,Bioraffinaderi och energi
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- Bernin, D. (författare)
- University of Gothenburg, Sweden
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(creator_code:org_t)
- 2017-05-13
- 2017
- Engelska.
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Ingår i: Caries Research. - : S. Karger AG. - 0008-6568 .- 1421-976X. ; 51:3, s. 255-263
- Relaterad länk:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Dyes currently used to stain carious dentine have a limited capacity to discriminate normal dentine from carious dentine, which may result in overexcavation. Consequently, finding a selective dye is still a challenge. However, there is evidence that hydrazine-based dyes, via covalent bonds to functional groups, bind specifically to carious dentine. The aim of this study was to investigate the possible formation of covalent bonds between carious dentine and N-15(2)-hydrazine and the hydrazine-based dye, N-15(2)-labelled Lucifer Yellow, respectively. Powdered dentine from extracted carious and normal teeth was exposed to the dyes, and the staining reactions were analysed using time-of-flight secondary ion mass spectrometry (ToF-SIMS), solid-state C-13-labelled nuclear magnetic resonance (NMR) and N-15-NMR spectroscopy. The results showed that N-15(2)-hydrazine and N-15(2)-labelled Lucifer Yellow both bind to carious dentine but not to normal dentine. It can thus be concluded that hydrazine-based dyes can be used to stain carious dentine and leave normal dentine unstained. (C) 2017 S. Karger AG, Basel
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Odontologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dentistry (hsv//eng)
Nyckelord
- Carious dentine
- Covalent binding
- Hydrazine
- Normal dentine
- NMR
- ToF-SIMS
- matrix proteins
- peritubular dentin
- cavity preparation
- in-vitro
- bone
- c-13
- spectroscopy
- collagen
- n-15
- dye
- Dentistry
- Oral Surgery & Medicine
- Covalent binding; Hydrazine; Normal dentine; NMR; ToF-SIMS; Carious dentine
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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