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Father's environmen...
Father's environment before conception and asthma risk in his children: a multi-generation analysis of the Respiratory Health In Northern Europe study
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- Svanes, C. (författare)
- Centre for International Health, University of Bergen, Norway; Department of Occupational Medicine, Haukeland University Hospital, Bergen, Norway; Department of Clinical Science, University of Bergen, Norway
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- Koplin, J. (författare)
- Centre for International Health, University of Bergen, Norway; School of Population and Global Health, University of Melbourne, Australia; Murdoch Childrens Research Institute, Melbourne, Australia
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- Skulstad, S. M. (författare)
- Department of Clinical Science, University of Bergen, Norway; Department of Obstetrics, Oslo University Hospital, Rikshospitalet, Oslo, Norway
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- Johannessen, A. (författare)
- Department of Clinical Science, University of Bergen, Norway; Centre for Clinical Research, Haukeland University Hospital, Bergen, Norway
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- Jögi, Rain (författare)
- Uppsala universitet,Lung- allergi- och sömnforskning,Lung Clinic, Foundation Tartu University Clinics, Tartu, Estonia; Department of Pulmonary Medicine, Tartu University, Estonia
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- Benediktsdottir, B. (författare)
- Department of Allergy, Respiratory Medicine and Sleep, Landspitali University Hospital, Reykjavik, Iceland; University of Iceland, Medical Faculty
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- Bråbäck, Lennart (författare)
- Umeå universitet,Yrkes- och miljömedicin,Occupational and Environmental Medicine, Department of Public Health and Clinical Medicine, Umeå University, Sweden
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- Carsin, A. E. (författare)
- Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain
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- Dharmage, S. (författare)
- Department of Clinical Science, University of Bergen, Norway; School of Population and Global Health, University of Melbourne, Australia
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- Dratva, J. (författare)
- Centre for International Health, University of Bergen, Norway; Department of Epidemiology and Public Health, Gender & Health, Swiss Tropical and Public Health Institute, Basel University, Switzerland
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- Forsberg, Bertil (författare)
- Umeå universitet,Yrkes- och miljömedicin,Arcum,Occupational and Environmental Medicine, Department of Public Health and Clinical Medicine, Umeå University, Sweden
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- Gislason, T. (författare)
- Department of Allergy, Respiratory Medicine and Sleep, Landspitali University Hospital, Reykjavik, Iceland; University of Iceland, Medical Faculty
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- Heinrich, J. (författare)
- Institute of Epidemiology I, Helmholtz Zentrum, Munich, Germany
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- Holm, Mathias, 1969 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa, enheten för arbets-och miljömedicin,Institute of Medicine, Department of Public Health and Community Medicine, Section of Occupational and environmental medicine,Occupational and Environmental Medicine, Sahlgrenska Academy, University of Gothenburg, Sweden
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- Janson, Christer (författare)
- Uppsala universitet,Lung- allergi- och sömnforskning
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- Jarvis, D. (författare)
- Faculty of Medicine, National Heart & Lung Institute, Imperial College, London, UK
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Jogi, R. (författare)
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- Krauss-Etschmann, S. (författare)
- Research Center Borstel, Leibniz- Center for Medicine and Biosciences, Divison of Experimental Asthma Research, University of Kiel, Germany
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- Lindberg, Eva (författare)
- Uppsala universitet,Lung- allergi- och sömnforskning
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- Macsali, F. (författare)
- Department of Obstetrics and Gynecology, Haukeland, University Hospital, Bergen, Norway and
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- Malinovschi, Andrei, 1978- (författare)
- Uppsala universitet,Klinisk fysiologi
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- Modig, Lars (författare)
- Umeå universitet,Yrkes- och miljömedicin,Centre for International Health, University of Bergen, Norway,Occupational and Environmental Medicine, Department of Public Health and Clinical Medicine, Umea ̊ University, Sweden
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- Norbäck, Dan (författare)
- Uppsala universitet,Arbets- och miljömedicin
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- Omenaas, E. (författare)
- Department of Clinical Science, University of Bergen, Norway; Centre for Clinical Research, Haukeland University Hospital, Bergen, Norway
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- Saure, E. W. (författare)
- Department of Clinical Science, University of Bergen, Norway
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- Sigsgaard, T. (författare)
- Department of Public Health, Aarhus University, Denmark
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- Skorge, T. D. (författare)
- Department of Occupational Medicine, Haukeland University Hospital, Bergen, Norway
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Svanes, O. (författare)
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- Torén, Kjell, 1952 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa, enheten för arbets-och miljömedicin,Institute of Medicine, Department of Public Health and Community Medicine, Section of Occupational and environmental medicine,Occupational and Environmental Medicine, Sahlgrenska Academy, University of Gothenburg, Sweden
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- Torres, C. (författare)
- Department of Clinical Science, University of Bergen, Norway
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- Schlunssen, V. (författare)
- Department of Public Health; Aarhus University, Denmark
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- Real, F. G. (författare)
- Department of Clinical Science, University of Bergen, Norway; Department of Obstetrics and Gynecology, Haukeland, University Hospital, Bergen, Norway
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- Svanes, Øistein (författare)
- Department of Occupational Medicine, Haukeland University Hospital, Bergen, Norway; Department of Clinical Science, University of Bergen, Norway
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(creator_code:org_t)
- 2016-08-25
- 2017
- Engelska.
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Ingår i: International Journal of Epidemiology. - : Oxford University Press (OUP). - 0300-5771 .- 1464-3685. ; 46:1, s. 235-245
- Relaterad länk:
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https://academic.oup...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Background: Whereas it is generally accepted that maternal environment plays a key role in child health, emerging evidence suggests that paternal environment before conception also impacts child health. We aimed to investigate the association between children's asthma risk and parental smoking and welding exposures prior to conception. Methods: In a longitudinal, multi-country study, parents of 24 168 offspring aged 2-51 years provided information on their life-course smoking habits, occupational exposure to welding and metal fumes, and offspring's asthma before/after age 10 years and hay fever. Logistic regressions investigated the relevant associations controlled for age, study centre, parental characteristics (age, asthma, education) and clustering by family. Results: Non-allergic early-onset asthma (asthma without hay fever, present in 5.8%) was more common in the offspring with fathers who smoked before conception {odds ratio [OR] = 1.68 [95% confidence interval (CI) = 1.18-2.41]}, whereas mothers' smoking before conception did not predict offspring asthma. The risk was highest if father started smoking before age 15 years [3.24 (1.67-6.27)], even if he stopped more than 5 years before conception [2.68 (1.17-6.13)]. Fathers' pre-conception welding was independently associated with non-allergic asthma in his offspring [1.80 (1.29-2.50)]. There was no effect if the father started welding or smoking after birth. The associations were consistent across countries. Conclusions: Environmental exposures in young men appear to influence the respiratory health of their offspring born many years later. Influences during susceptible stages of spermatocyte development might be important and needs further investigation in humans. We hypothesize that protecting young men from harmful exposures may lead to improved respiratory health in future generations.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Nyckelord
- asthma
- epidemiology
- smoking
- occupational exposure
- epigenesis
- grandmaternal smoking patterns
- sperm microrna content
- slow growth
- period
- transgenerational responses
- cigarette-smoking
- tobacco-smoke
- childhood asthma
- germ-line
- follow-up
- exposure
- Public
- Environmental & Occupational Health
- asthma
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Svanes, C.
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Koplin, J.
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Skulstad, S. M.
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Johannessen, A.
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Jögi, Rain
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Benediktsdottir, ...
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visa fler...
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Bråbäck, Lennart
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Carsin, A. E.
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Dharmage, S.
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Dratva, J.
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Forsberg, Bertil
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Gislason, T.
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Heinrich, J.
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Holm, Mathias, 1 ...
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Janson, Christer
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Jarvis, D.
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Jogi, R.
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Krauss-Etschmann ...
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Lindberg, Eva
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Macsali, F.
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Malinovschi, And ...
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Modig, Lars
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Norbäck, Dan
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Omenaas, E.
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Saure, E. W.
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Sigsgaard, T.
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Skorge, T. D.
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Svanes, O.
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Torén, Kjell, 19 ...
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Torres, C.
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Schlunssen, V.
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Real, F. G.
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Svanes, Øistein
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Göteborgs universitet
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